| Amyloid precursor protein processing and Alzheimer's disease RJ O'brien, PC Wong Annual review of neuroscience 34 (1), 185-204, 2011 | 2529 | 2011 |
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ... Neuron 14 (6), 1105-1116, 1995 | 1756 | 1995 |
| BACE1 is the major β-secretase for generation of Aβ peptides by neurons H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong Nature neuroscience 4 (3), 233-234, 2001 | 1488 | 2001 |
| An overview of APP processing enzymes and products VW Chow, MP Mattson, PC Wong, M Gleichmann Neuromolecular medicine 12, 1-12, 2010 | 957 | 2010 |
| Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm PC Wong, H Zheng, H Chen, MW Becher, DJS Sirinathsinghji, ... Nature 387 (6630), 288-292, 1997 | 929 | 1997 |
| Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease LB Yang, K Lindholm, R Yan, M Citron, W Xia, XL Yang, T Beach, L Sue, ... Nature medicine 9 (1), 3-4, 2003 | 915 | 2003 |
| GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport BD Freibaum, Y Lu, R Lopez-Gonzalez, NC Kim, S Almeida, KH Lee, ... Nature 525 (7567), 129-133, 2015 | 899 | 2015 |
| Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ... Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994 | 808 | 1994 |
| Bace1 modulates myelination in the central and peripheral nervous system X Hu, CW Hicks, W He, P Wong, WB Macklin, BD Trapp, R Yan Nature neuroscience 9 (12), 1520-1525, 2006 | 775 | 2006 |
| The β-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential R Vassar, DM Kovacs, R Yan, PC Wong Journal of neuroscience 29 (41), 12787-12794, 2009 | 718 | 2009 |
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ... Journal of Neuroscience 25 (50), 11693-11709, 2005 | 693 | 2005 |
| Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ... Proceedings of the National Academy of Sciences 101 (10), 3632-3637, 2004 | 661 | 2004 |
| Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria J Liu, C Lillo, PA Jonsson, CV Velde, CM Ward, TM Miller, ... Neuron 43 (1), 5-17, 2004 | 655 | 2004 |
| TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD JP Ling, O Pletnikova, JC Troncoso, PC Wong Science 349 (6248), 650-655, 2015 | 544 | 2015 |
| Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues M Watanabe, M Dykes-Hoberg, VC Culotta, DL Price, PC Wong, ... Neurobiology of disease 8 (6), 933-941, 2001 | 537 | 2001 |
| Association of γ-secretase with lipid rafts in post-Golgi and endosome membranes KS Vetrivel, H Cheng, W Lin, T Sakurai, T Li, N Nukina, PC Wong, H Xu, ... Journal of Biological Chemistry 279 (43), 44945-44954, 2004 | 536 | 2004 |
| Effects of PS1 deficiency on membrane protein trafficking in neurons S Naruse, G Thinakaran, JJ Luo, JW Kusiak, T Tomita, T Iwatsubo, X Qian, ... Neuron 21 (5), 1213-1221, 1998 | 478 | 1998 |
| Neurofilaments are obligate heteropolymers in vivo MK Lee, Z Xu, PC Wong, DW Cleveland The Journal of cell biology 122 (6), 1337-1350, 1993 | 476 | 1993 |
| Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. S Rabizadeh, EB Gralla, DR Borchelt, R Gwinn, JS Valentine, S Sisodia, ... Proceedings of the National Academy of Sciences 92 (7), 3024-3028, 1995 | 435 | 1995 |
| Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects R Vassar, PH Kuhn, C Haass, ME Kennedy, L Rajendran, PC Wong, ... Journal of neurochemistry 130 (1), 4-28, 2014 | 420 | 2014 |
