| Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia K Keeshan, Y He, BJ Wouters, O Shestova, L Xu, H Sai, CG Rodriguez, ... Cancer cell 10 (5), 401-411, 2006 | 292 | 2006 |
| The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor I Maillard, LL Tu, A Sambandam, Y Yashiro-Ohtani, J Millholland, ... The Journal of experimental medicine 203 (10), 2239-2245, 2006 | 269 | 2006 |
| Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1 BJ Wouters, MA Jorda, K Keeshan, I Louwers, ... Blood, The Journal of the American Society of Hematology 110 (10), 3706-3714, 2007 | 246 | 2007 |
| Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease PA Eyers, K Keeshan, N Kannan Trends in cell biology 27 (4), 284-298, 2017 | 232 | 2017 |
| The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression YX Chen, J Yan, K Keeshan, AT Tubbs, H Wang, A Silva, EJ Brown, ... Proceedings of the National Academy of Sciences 103 (4), 1018-1023, 2006 | 210 | 2006 |
| Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia PH Dedhia, K Keeshan, S Uljon, L Xu, ME Vega, O Shestova, ... Blood, The Journal of the American Society of Hematology 116 (8), 1321-1328, 2010 | 186 | 2010 |
| Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding K Keeshan, W Bailis, PH Dedhia, ME Vega, O Shestova, L Xu, K Toscano, ... Blood, The Journal of the American Society of Hematology 116 (23), 4948-4957, 2010 | 139 | 2010 |
| Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis A Di Bacco, K Keeshan, SL McKenna, TG Cotter The oncologist 5 (5), 405-415, 2000 | 139 | 2000 |
| Transcription activation function of C/EBPα is required for induction of granulocytic differentiation K Keeshan, G Santilli, F Corradini, D Perrotti, B Calabretta Blood 102 (4), 1267-1275, 2003 | 114 | 2003 |
| Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype K Keeshan, KI Mills, TG Cotter, SL McKenna Leukemia 15 (12), 1823-1833, 2001 | 98 | 2001 |
| Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells DM Foulkes, DP Byrne, W Yeung, S Shrestha, FP Bailey, S Ferries, ... Science signaling 11 (549), eaat7951, 2018 | 79 | 2018 |
| Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation SM Ryan, GW O’Keeffe, C O’Connor, K Keeshan, YM Nolan Brain, behavior, and immunity 33, 7-13, 2013 | 79 | 2013 |
| Targeting the arginine metabolic brake enhances immunotherapy for leukaemia F Mussai, R Wheat, E Sarrou, S Booth, V Stavrou, L Fultang, T Perry, ... International journal of cancer 145 (8), 2201-2208, 2019 | 78 | 2019 |
| Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias S Chaudhury, C O’Connor, A Cañete, J Bittencourt-Silvestre, E Sarrou, ... Nature communications 9 (1), 5280, 2018 | 70 | 2018 |
| Tribbles in acute leukemia KL Liang, L Rishi, K Keeshan Blood, The Journal of the American Society of Hematology 121 (21), 4265-4270, 2013 | 62 | 2013 |
| Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation L Rishi, M Hannon, M Salome, M Hasemann, AK Frank, J Campos, ... Blood, The Journal of the American Society of Hematology 123 (15), 2389-2400, 2014 | 61 | 2014 |
| The functionally diverse roles of tribbles F Lohan, K Keeshan Biochemical Society Transactions 41 (4), 1096-1100, 2013 | 61 | 2013 |
| Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia K Keeshan, O Shestova, LS Ussin, WS Pear Blood Cells, Molecules, and Diseases 40 (1), 119-121, 2008 | 58 | 2008 |
| BRD4-mediated repression of p53 is a target for combination therapy in AML AL Latif, A Newcombe, S Li, K Gilroy, NA Robertson, X Lei, HJS Stewart, ... Nature communications 12 (1), 241, 2021 | 57 | 2021 |
| Pseudokinases: a tribble‐edged sword L Richmond, K Keeshan The FEBS Journal 287 (19), 4170-4182, 2020 | 57 | 2020 |