Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ... Nature genetics 45 (12), 1452-1458, 2013 | 4587 | 2013 |
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ... Nature genetics 41 (10), 1088-1093, 2009 | 4289* | 2009 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ... Nature genetics 51 (3), 414-430, 2019 | 2470 | 2019 |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ... Nature genetics 43 (5), 429-435, 2011 | 2249 | 2011 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 1338 | 2022 |
The genetic landscape of Alzheimer disease: clinical implications and perspectives C Van Cauwenberghe, C Van Broeckhoven, K Sleegers Genetics in Medicine 18 (5), 421-430, 2016 | 1063 | 2016 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ... Nature genetics 49 (9), 1373-1384, 2017 | 959 | 2017 |
APOE and Alzheimer disease: a major gene with semi-dominant inheritance E Genin, D Hannequin, D Wallon, K Sleegers, M Hiltunen, O Combarros, ... Molecular psychiatry 16 (9), 903-907, 2011 | 806 | 2011 |
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis G Kleinberger, Y Yamanishi, M Suárez-Calvet, E Czirr, E Lohmann, ... Science translational medicine 6 (243), 243ra86-243ra86, 2014 | 794 | 2014 |
A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene … I Gijselinck, T Van Langenhove, J van der Zee, K Sleegers, S Philtjens, ... The Lancet Neurology 11 (1), 54-65, 2012 | 790 | 2012 |
Molecular genetics of early-onset Alzheimer's disease revisited R Cacace, K Sleegers, C Van Broeckhoven Alzheimer's & dementia 12 (6), 733-748, 2016 | 730 | 2016 |
sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers M Suárez‐Calvet, G Kleinberger, MÁ Araque Caballero, M Brendel, ... EMBO molecular medicine 8 (5), 466-476, 2016 | 494 | 2016 |
APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy K Sleegers, N Brouwers, I Gijselinck, J Theuns, D Goossens, J Wauters, ... Brain 129 (11), 2977-2983, 2006 | 478 | 2006 |
Genetic insights in Alzheimer's disease K Bettens, K Sleegers, C Van Broeckhoven The lancet neurology 12 (1), 92-104, 2013 | 472 | 2013 |
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology J Chapuis, F Hansmannel, M Gistelinck, A Mounier, ... Molecular psychiatry 18 (11), 1225-1234, 2013 | 429 | 2013 |
Potent amyloidogenicity and pathogenicity of Aβ43 T Saito, T Suemoto, N Brouwers, K Sleegers, S Funamoto, N Mihira, ... Nature neuroscience 14 (8), 1023-1032, 2011 | 360 | 2011 |
A Pan‐European Study of the C9orf72 Repeat Associated with FTLD: Geographic Prevalence, Genomic Instability, and Intermediate Repeats J van der Zee, I Gijselinck, L Dillen, T Van Langenhove, J Theuns, ... Human mutation 34 (2), 363-373, 2013 | 337 | 2013 |
STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy H Stamberger, M Nikanorova, MH Willemsen, P Accorsi, M Angriman, ... Neurology 86 (10), 954-962, 2016 | 331 | 2016 |
Molecular genetics of Alzheimer's disease: an update N Brouwers, K Sleegers, C Van Broeckhoven Annals of medicine 40 (8), 562-583, 2008 | 302 | 2008 |
A novel Alzheimer disease locus located near the gene encoding tau protein G Jun, CA Ibrahim-Verbaas, M Vronskaya, JC Lambert, J Chung, AC Naj, ... Molecular psychiatry 21 (1), 108-117, 2016 | 298 | 2016 |