| Drug repurposing: progress, challenges and recommendations S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ... Nature reviews Drug discovery 18 (1), 41-58, 2019 | 3976 | 2019 |
| A novel mechanism for activation of the protein kinase Aurora A PA Eyers, E Erikson, LG Chen, JL Maller Current Biology 13 (8), 691-697, 2003 | 454 | 2003 |
| Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution PA Eyers, M Craxton, N Morricel, P Cohen, M Goedert Chemistry & biology 5 (6), 321-328, 1998 | 397 | 1998 |
| Validating Aurora B as an anti-cancer drug target F Girdler, KE Gascoigne, PA Eyers, S Hartmuth, C Crafter, KM Foote, ... Journal of cell science 119 (17), 3664-3675, 2006 | 356 | 2006 |
| Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway P Kovarik, D Stoiber, PA Eyers, R Menghini, A Neininger, M Gaestel, ... Proceedings of the National Academy of Sciences 96 (24), 13956-13961, 1999 | 351 | 1999 |
| Paradoxical activation of Raf by a novel Raf inhibitor CA Hall-Jackson, PA Eyers, P Cohen, M Goedert, FT Boyle, N Hewitt, ... Chemistry & biology 6 (8), 559-568, 1999 | 307 | 1999 |
| A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties JM Murphy, Q Zhang, SN Young, ML Reese, FP Bailey, PA Eyers, ... Biochemical Journal 457 (2), 323-334, 2014 | 286 | 2014 |
| Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease PA Eyers, K Keeshan, N Kannan Trends in cell biology 27 (4), 284-298, 2017 | 232 | 2017 |
| Local protein kinase A action proceeds through intact holoenzymes FD Smith, JL Esseltine, PJ Nygren, D Veesler, DP Byrne, M Vonderach, ... Science 356 (6344), 1288-1293, 2017 | 211 | 2017 |
| A framework for identification of actionable cancer genome dependencies in small cell lung cancer ML Sos, F Dietlein, M Peifer, J Schöttle, H Balke-Want, C Müller, M Koker, ... Proceedings of the National Academy of Sciences 109 (42), 17034-17039, 2012 | 204 | 2012 |
| Day of the dead: pseudokinases and pseudophosphatases in physiology and disease V Reiterer, PA Eyers, H Farhan Trends in cell biology 24 (9), 489-505, 2014 | 194 | 2014 |
| Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation G Hardman, S Perkins, PJ Brownridge, CJ Clarke, DP Byrne, ... The EMBO journal 38 (21), e100847, 2019 | 182* | 2019 |
| New perspectives, opportunities, and challenges in exploring the human protein kinome LJ Wilson, A Linley, DE Hammond, FE Hood, JM Coulson, DJ MacEwan, ... Cancer research 78 (1), 15-29, 2018 | 180 | 2018 |
| Regulation of Xenopus Aurora A activation by TPX2 PA Eyers, JL Maller Journal of Biological Chemistry 279 (10), 9008-9015, 2004 | 164 | 2004 |
| Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography CE Haydon, PA Eyers, LD Aveline-Wolf, KA Resing, JL Maller, NG Ahn Molecular & Cellular Proteomics 2 (10), 1055-1067, 2003 | 163 | 2003 |
| A single sulfatase is required to access colonic mucin by a gut bacterium AS Luis, C Jin, GV Pereira, RWP Glowacki, SR Gugel, S Singh, DP Byrne, ... Nature 598 (7880), 332-337, 2021 | 136 | 2021 |
| VX-680 inhibits Aurora A and Aurora B kinase activity in human cells RK Tyler, N Shpiro, R Marquez, PA Eyers Cell cycle 6 (22), 2846-2854, 2007 | 136 | 2007 |
| Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580 PA Eyers, P Van Den Ijssel, RA Quinlan, M Goedert, P Cohen FEBS letters 451 (2), 191-196, 1999 | 133 | 1999 |
| Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237 DA Sloane, MZ Trikic, MLH Chu, MBAC Lamers, CS Mason, I Mueller, ... ACS chemical biology 5 (6), 563-576, 2010 | 122 | 2010 |
| Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential B Meyer, J Chiaravalli, S Gellenoncourt, P Brownridge, DP Bryne, LA Daly, ... Nature Communications 12 (1), 5553, 2021 | 119* | 2021 |
Claire E. EyersAPVC (Research); Professor, Department of Biochemistry and Systems Biology, ISMIB, University of在 liverpool.ac.uk 的電子郵件地址已通過驗證