| Pathogen recognition and innate immunity S Akira, S Uematsu, O Takeuchi Cell 124 (4), 783-801, 2006 | 15536 | 2006 |
| Pattern recognition receptors and inflammation O Takeuchi, S Akira Cell 140 (6), 805-820, 2010 | 10513 | 2010 |
| A Toll-like receptor recognizes bacterial DNA H Hemmi, O Takeuchi, T Kawai, T Kaisho, S Sato, H Sanjo, M Matsumoto, ... Nature 408 (6813), 740-745, 2000 | 8566 | 2000 |
| Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product K Hoshino, O Takeuchi, T Kawai, H Sanjo, T Ogawa, Y Takeda, K Takeda, ... The Journal of Immunology 162 (7), 3749-3752, 1999 | 4857 | 1999 |
| Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses H Kato, O Takeuchi, S Sato, M Yoneyama, M Yamamoto, K Matsui, ... Nature 441 (7089), 101-105, 2006 | 4543 | 2006 |
| Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components O Takeuchi, K Hoshino, T Kawai, H Sanjo, H Takada, T Ogawa, K Takeda, ... Immunity 11 (4), 443-451, 1999 | 4321 | 1999 |
| Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway M Yamamoto, S Sato, H Hemmi, K Hoshino, T Kaisho, H Sanjo, ... Science 301 (5633), 640-643, 2003 | 4184 | 2003 |
| Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway H Hemmi, T Kaisho, O Takeuchi, S Sato, H Sanjo, K Hoshino, T Horiuchi, ... Nature immunology 3 (2), 196-200, 2002 | 3348 | 2002 |
| IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction T Kawai, K Takahashi, S Sato, C Coban, H Kumar, H Kato, KJ Ishii, ... Nature immunology 6 (10), 981-988, 2005 | 3164 | 2005 |
| Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production T Saitoh, N Fujita, MH Jang, S Uematsu, BG Yang, T Satoh, H Omori, ... Nature 456 (7219), 264-268, 2008 | 2334 | 2008 |
| Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 H Kato, O Takeuchi, E Mikamo-Satoh, R Hirai, T Kawai, K Matsushita, ... The Journal of experimental medicine 205 (7), 1601-1610, 2008 | 1982 | 2008 |
| TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity MU Gack, YC Shin, CH Joo, T Urano, C Liang, L Sun, O Takeuchi, S Akira, ... Nature 446 (7138), 916-920, 2007 | 1914 | 2007 |
| Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins O Takeuchi, S Sato, T Horiuchi, K Hoshino, K Takeda, Z Dong, RL Modlin, ... The Journal of Immunology 169 (1), 10-14, 2002 | 1869 | 2002 |
| Cell type-specific involvement of RIG-I in antiviral response H Kato, S Sato, M Yoneyama, M Yamamoto, S Uematsu, K Matsui, ... Immunity 23 (1), 19-28, 2005 | 1802 | 2005 |
| Discrimination of bacterial lipoproteins by Toll-like receptor 6 O Takeuchi, T Kawai, PF Mühlradt, M Morr, JD Radolf, A Zychlinsky, ... International immunology 13 (7), 933-940, 2001 | 1751 | 2001 |
| Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling M Yamamoto, S Sato, K Mori, K Hoshino, O Takeuchi, K Takeda, S Akira The Journal of Immunology 169 (12), 6668-6672, 2002 | 1713 | 2002 |
| Innate immunity to virus infection O Takeuchi, S Akira Immunological reviews 227 (1), 75-86, 2009 | 1514 | 2009 |
| TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway M Yamamoto, S Sato, H Hemmi, S Uematsu, K Hoshino, T Kaisho, ... Nature immunology 4 (11), 1144-1150, 2003 | 1463 | 2003 |
| Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible … T Kawai, O Takeuchi, T Fujita, J Inoue, PF Muhlradt, S Sato, K Hoshino, ... The Journal of Immunology 167 (10), 5887-5894, 2001 | 1461 | 2001 |
| Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 M Yamamoto, S Sato, H Hemmi, H Sanjo, S Uematsu, T Kaisho, ... Nature 420 (6913), 324-329, 2002 | 1402 | 2002 |
