| Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter O Boudker, RM Ryan, D Yernool, K Shimamoto, E Gouaux Nature 445 (7126), 387-393, 2007 | 554 | 2007 |
| Mechanisms of glutamate transport RJ Vandenberg, RM Ryan Physiological reviews 93 (4), 1621-1657, 2013 | 391 | 2013 |
| Targeting glutamine transport to suppress melanoma cell growth Q Wang, KA Beaumont, NJ Otte, J Font, CG Bailey, M van Geldermalsen, ... International journal of cancer 135 (5), 1060-1071, 2014 | 246 | 2014 |
| Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria CG Bailey, RM Ryan, AD Thoeng, C Ng, K King, JM Vanslambrouck, ... The Journal of clinical investigation 121 (1), 446-453, 2011 | 140 | 2011 |
| The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway RM Ryan, AD Mitrovic, RJ Vandenberg Journal of Biological Chemistry 279 (20), 20742-20751, 2004 | 139 | 2004 |
| The uncoupled chloride conductance of a bacterial glutamate transporter homolog RM Ryan, JA Mindell Nature structural & molecular biology 14 (5), 365-371, 2007 | 126 | 2007 |
| Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii RM Ryan, ELR Compton, JA Mindell Journal of Biological Chemistry 284 (26), 17540-17548, 2009 | 122 | 2009 |
| Glycine transport inhibitors for the treatment of pain RJ Vandenberg, RM Ryan, JE Carland, WL Imlach, MJ Christie Trends in pharmacological sciences 35 (8), 423-430, 2014 | 92 | 2014 |
| Position of the Third Na+ Site in the Aspartate Transporter GltPh and the Human Glutamate Transporter, EAAT1 T Bastug, G Heinzelmann, S Kuyucak, M Salim, RJ Vandenberg, ... PloS one 7 (3), e33058, 2012 | 89 | 2012 |
| Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5 AJ Scopelliti, J Font, RJ Vandenberg, O Boudker, RM Ryan Nature Communications 9 (1), 38, 2018 | 88 | 2018 |
| Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1 RM Ryan, RJ Vandenberg Journal of Biological Chemistry 277 (16), 13494-13500, 2002 | 81 | 2002 |
| Glutamate transporters have a chloride channel with two hydrophobic gates I Chen, S Pant, Q Wu, RJ Cater, M Sobti, RJ Vandenberg, AG Stewart, ... Nature 591 (7849), 327-331, 2021 | 61 | 2021 |
| Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways M van Geldermalsen, LE Quek, N Turner, N Freidman, A Pang, YF Guan, ... BMC cancer 18, 1-14, 2018 | 59 | 2018 |
| Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) in … Q Zhou, AF Phoa, RH Abbassi, M Hoque, TA Reekie, JS Font, RM Ryan, ... Journal of Medicinal Chemistry 60 (5), 2052-2070, 2017 | 57 | 2017 |
| Amino acid transporters and exchangers from the SLC1A family: structure, mechanism and roles in physiology and cancer N Freidman, I Chen, Q Wu, C Briot, J Holst, J Font, R Vandenberg, R Ryan Neurochemical Research 45, 1268-1286, 2020 | 54 | 2020 |
| Effects of sumatriptan on rat medullary dorsal horn neurons EA Jennings, RM Ryan, MJ Christie Pain 111 (1), 30-37, 2004 | 53 | 2004 |
| Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth Q Wang, T Grkovic, J Font, S Bonham, RH Pouwer, CG Bailey, AM Moran, ... ACS Chemical Biology 9 (6), 1369-1376, 2014 | 50 | 2014 |
| The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation RJ Cater, RJ Vandenberg, RM Ryan Biophysical journal 107 (3), 621-629, 2014 | 47 | 2014 |
| Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members AJ Scopelliti, RM Ryan, RJ Vandenberg Journal of Biological Chemistry 288 (12), 8250-8257, 2013 | 42 | 2013 |
| Slips, leaks and channels in glutamate transporters R Vandenberg, S Huang, R Ryan Channels 2 (1), 51-58, 2008 | 42 | 2008 |