Multiplex genome engineering using CRISPR/Cas systems L Cong, FA Ran, D Cox, S Lin, R Barretto, N Habib, PD Hsu, X Wu, ... Science 339 (6121), 819-823, 2013 | 18825 | 2013 |
DNA targeting specificity of RNA-guided Cas9 nucleases PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ... Nature biotechnology 31 (9), 827-832, 2013 | 5634 | 2013 |
RNA-guided editing of bacterial genomes using CRISPR-Cas systems W Jiang, D Bikard, D Cox, F Zhang, LA Marraffini Nature biotechnology 31 (3), 233-239, 2013 | 3122 | 2013 |
CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA LA Marraffini, EJ Sontheimer science 322 (5909), 1843-1845, 2008 | 2257 | 2008 |
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system D Bikard, W Jiang, P Samai, A Hochschild, F Zhang, LA Marraffini Nucleic acids research 41 (15), 7429-7437, 2013 | 1444 | 2013 |
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea LA Marraffini, EJ Sontheimer Nature Reviews Genetics 11 (3), 181-190, 2010 | 1361 | 2010 |
CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity R Barrangou, LA Marraffini Molecular cell 54 (2), 234-244, 2014 | 1076 | 2014 |
Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials D Bikard, CW Euler, W Jiang, PM Nussenzweig, GW Goldberg, X Duportet, ... Nature biotechnology 32 (11), 1146-1150, 2014 | 991 | 2014 |
Self versus non-self discrimination during CRISPR RNA-directed immunity LA Marraffini, EJ Sontheimer Nature 463 (7280), 568-571, 2010 | 977 | 2010 |
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria LA Marraffini, AC DeDent, O Schneewind Microbiology and molecular biology reviews 70 (1), 192-221, 2006 | 971 | 2006 |
CRISPR-Cas immunity in prokaryotes LA Marraffini Nature 526 (7571), 55-61, 2015 | 933 | 2015 |
Target DNA interference with crRNA EJ Sontheimer, LA Marraffini US Patent App. 12/565,589, 2010 | 621 | 2010 |
Cas9 specifies functional viral targets during CRISPR–Cas adaptation R Heler, P Samai, JW Modell, C Weiner, GW Goldberg, D Bikard, ... Nature 519 (7542), 199-202, 2015 | 571 | 2015 |
Co-transcriptional DNA and RNA cleavage during type III CRISPR-Cas immunity P Samai, N Pyenson, W Jiang, GW Goldberg, A Hatoum-Aslan, ... Cell 161 (5), 1164-1174, 2015 | 496 | 2015 |
CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection D Bikard, A Hatoum-Aslan, D Mucida, LA Marraffini Cell host & microbe 12 (2), 177-186, 2012 | 474 | 2012 |
Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers O Niewoehner, C Garcia-Doval, JT Rostøl, C Berk, F Schwede, L Bigler, ... Nature 548 (7669), 543-548, 2017 | 447 | 2017 |
Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site A Hatoum-Aslan, I Maniv, LA Marraffini Proceedings of the National Academy of Sciences 108 (52), 21218-21222, 2011 | 433 | 2011 |
Protein sorting to the cell wall envelope of Gram-positive bacteria H Ton-That, LA Marraffini, O Schneewind Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1694 (1-3), 269-278, 2004 | 347 | 2004 |
Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting GW Goldberg, W Jiang, D Bikard, LA Marraffini Nature 514 (7524), 633-637, 2014 | 312 | 2014 |
Crispr-cas component systems, methods and compositions for sequence manipulation F Zhang, L Cong, DBT Cox, P Hsu, LIN Shuailiang, RAN Fei, RJ Platt, ... US Patent App. 14/105,035, 2014 | 302 | 2014 |