| Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages EM Palsson-McDermott, AM Curtis, G Goel, MAR Lauterbach, FJ Sheedy, ... Cell metabolism 21 (1), 65-80, 2015 | 1231 | 2015 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 809 | 2012 |
| Pyruvate kinase: Function, regulation and role in cancer WJ Israelsen, MG Vander Heiden Seminars in cell & developmental biology 43, 43-51, 2015 | 578 | 2015 |
| PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, AM Hosios, G Bellinger, ... Cell 155 (2), 397-409, 2013 | 567 | 2013 |
| Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction W Qi, HA Keenan, Q Li, A Ishikado, A Kannt, T Sadowski, MA Yorek, ... Nature medicine 23 (6), 753-762, 2017 | 406 | 2017 |
| Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis YH Wang, WJ Israelsen, D Lee, WC Vionnie, NT Jeanson, CB Clish, ... Cell 158 (6), 1309-1323, 2014 | 377 | 2014 |
| Metabolic pathway alterations that support cell proliferation MG Vander Heiden, SY Lunt, TL Dayton, BP Fiske, WJ Israelsen, ... Cold Spring Harbor symposia on quantitative biology 76, 325-334, 2011 | 343 | 2011 |
| Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation SY Lunt, V Muralidhar, AM Hosios, WJ Israelsen, DY Gui, L Newhouse, ... Molecular cell 57 (1), 95-107, 2015 | 261 | 2015 |
| Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma TL Dayton, V Gocheva, KM Miller, WJ Israelsen, A Bhutkar, CB Clish, ... Genes & development 30 (9), 1020-1033, 2016 | 142 | 2016 |
| ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model J Jiang, MJ Walsh, KR Brimacombe, D Anastasiou, Y Yu, WJ Israelsen, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2013 | 78 | 2013 |
| 2-Oxo-N-aryl-1, 2, 3, 4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase MJ Walsh, KR Brimacombe, H Veith, JM Bougie, T Daniel, W Leister, ... Bioorganic & medicinal chemistry letters 21 (21), 6322-6327, 2011 | 75 | 2011 |
| ATP consumption promotes cancer metabolism WJ Israelsen, MG Vander Heiden Cell 143 (5), 669-671, 2010 | 63 | 2010 |
| PKM2 is not required for colon cancer initiated by APC loss AN Lau, WJ Israelsen, J Roper, MJ Sinnamon, L Georgeon, TL Dayton, ... Cancer & metabolism 5, 1-7, 2017 | 44 | 2017 |
| Fibroblasts as an experimental model system for the study of comparative physiology CB Madelaire, AC Klink, WJ Israelsen, AG Hindle Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular …, 2022 | 23 | 2022 |
| Cancer‐associated mutations in human pyruvate kinase M2 impair enzyme activity VM Liu, AJ Howell, AM Hosios, Z Li, WJ Israelsen, MG Vander Heiden FEBS letters 594 (4), 646-664, 2020 | 23 | 2020 |
| Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma SM Davidson, DR Schmidt, JE Heyman, JP O'Brien, AC Liu, WJ Israelsen, ... Cancer research 82 (13), 2403-2416, 2022 | 19 | 2022 |
| Nesting box imager: Contact-free, real-time measurement of activity, surface body temperature, and respiratory rate applied to hibernating mouse models NE Kallmyer, HJ Shin, EA Brem, WJ Israelsen, NF Reuel PLoS Biology 17 (7), e3000406, 2019 | 15 | 2019 |
| Breeding and hibernation of captive meadow jumping mice (Zapus hudsonius) EA Brem, AD McNulty, WJ Israelsen Plos one 16 (5), e0240706, 2021 | 6 | 2021 |
| Cutaneous dermatophilosis in a meadow jumping mouse (Zapus hudsonius) TJ Caron, SC Artim, WJ Israelsen, HR Holcombe, JG Fox, ... Comparative Medicine 68 (1), 25-30, 2018 | 5 | 2018 |
| Differential dependence on aerobic glycolysis in normal and malignant hematopoietic stem and progenitor cells to sustain daughter cell production YH Wang, WJ Israelsen, D Lee, WC Vionnie, NT Jeanson, CB Clish, ... Blood 122 (21), 793, 2013 | 5 | 2013 |
Clary ClishSenior Director, Metabolomics, Broad Institute of MIT and Harvard在 broadinstitute.org 的电子邮件经过验证