| A system for stable expression of short interfering RNAs in mammalian cells TR Brummelkamp, R Bernards, R Agami science 296 (5567), 550-553, 2002 | 6893 | 2002 |
| Stable suppression of tumorigenicity by virus-mediated RNA interference TR Brummelkamp, R Bernards, R Agami Cancer cell 2 (3), 243-247, 2002 | 1721 | 2002 |
| A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors PM Voorhoeve, C Le Sage, M Schrier, AJM Gillis, H Stoop, R Nagel, ... Cell 124 (6), 1169-1181, 2006 | 1519 | 2006 |
| A large-scale RNAi screen in human cells identifies new components of the p53 pathway K Berns, EM Hijmans, J Mullenders, TR Brummelkamp, A Velds, ... Nature 428 (6981), 431-437, 2004 | 1475 | 2004 |
| The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis Q Huang, K Gumireddy, M Schrier, C Le Sage, R Nagel, S Nair, DA Egan, ... Nature cell biology 10 (2), 202-210, 2008 | 1244 | 2008 |
| Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation C Le Sage, R Nagel, DA Egan, M Schrier, E Mesman, A Mangiola, C Anile, ... The EMBO journal 26 (15), 3699-3708, 2007 | 994 | 2007 |
| RNA-binding protein Dnd1 inhibits microRNA access to target mRNA M Kedde, MJ Strasser, B Boldajipour, JAFO Vrielink, K Slanchev, ... Cell 131 (7), 1273-1286, 2007 | 887 | 2007 |
| Alternative cleavage and polyadenylation: extent, regulation and function R Elkon, AP Ugalde, R Agami Nature Reviews Genetics 14 (7), 496-506, 2013 | 855 | 2013 |
| miR-148 targets human DNMT3b protein coding region AM Duursma, M Kedde, M Schrier, C Le Sage, R Agami Rna 14 (5), 872-877, 2008 | 754 | 2008 |
| Interaction of c-Abl and p73α and their collaboration to induce apoptosis R Agami, G Blandino, M Oren, Y Shaul Nature 399 (6738), 809-813, 1999 | 729 | 1999 |
| MicroRNA regulation by RNA-binding proteins and its implications for cancer M Van Kouwenhove, M Kedde, R Agami Nature Reviews Cancer 11 (9), 644-656, 2011 | 708 | 2011 |
| The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo JT Huse, C Brennan, D Hambardzumyan, B Wee, J Pena, ... Genes & development 23 (11), 1327-1337, 2009 | 666 | 2009 |
| Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector M Van De Wetering, I Oving, V Muncan, MT Pon Fong, H Brantjes, ... EMBO reports 4 (6), 609-615, 2003 | 653 | 2003 |
| Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer R Nagel, C le Sage, B Diosdado, M van der Waal, JAF Oude Vrielink, ... Cancer research 68 (14), 5795-5802, 2008 | 623 | 2008 |
| eRNAs are required for p53-dependent enhancer activity and gene transcription CA Melo, J Drost, PJ Wijchers, H van de Werken, E de Wit, JAFO Vrielink, ... Molecular cell 49 (3), 524-535, 2013 | 584 | 2013 |
| A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility M Kedde, M Van Kouwenhove, W Zwart, JAF Oude Vrielink, R Elkon, ... Nature cell biology 12 (10), 1014-1020, 2010 | 491 | 2010 |
| Deregulation of microRNA-503 contributes to diabetes mellitus–induced impairment of endothelial function and reparative angiogenesis after limb ischemia A Caporali, M Meloni, C Völlenkle, D Bonci, GB Sala-Newby, R Addis, ... Circulation 123 (3), 282-291, 2011 | 490 | 2011 |
| Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage R Agami, R Bernards Cell 102 (1), 55-66, 2000 | 484 | 2000 |
| Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9 G Korkmaz, R Lopes, AP Ugalde, E Nevedomskaya, R Han, K Myacheva, ... Nature biotechnology 34 (2), 192-198, 2016 | 465 | 2016 |
| Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation B Slobodin, R Han, V Calderone, JAFO Vrielink, F Loayza-Puch, R Elkon, ... Cell 169 (2), 326-337. e12, 2017 | 442 | 2017 |