Immune checkpoint ligand PD-L1 is upregulated in pulmonary lymphangioleiomyomatosis K Maisel, MJ Merrilees, EN Atochina-Vasserman, L Lian, K Obraztsova, ... American journal of respiratory cell and molecular biology 59 (6), 723-732, 2018 | 51 | 2018 |
mTORC1 activation in lung mesenchyme drives sex-and age-dependent pulmonary structure and function decline K Obraztsova, MC Basil, R Rue, A Sivakumar, SM Lin, AR Mukhitov, ... Nature Communications 11 (1), 5640, 2020 | 37 | 2020 |
Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. coli D Sutormin, A Galivondzhyan, O Musharova, D Travin, A Rusanova, ... Nature communications 13 (1), 4524, 2022 | 33 | 2022 |
Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors V Stepanova, KV Dergilev, KR Holman, YV Parfyonova, ZI Tsokolaeva, ... Journal of Biological Chemistry 292 (50), 20528-20543, 2017 | 14 | 2017 |
Lymphangioleiomyomatosis (LAM) cell atlas Y Du, M Guo, Y Wu, A Wagner, AK Perl, K Wikenheiser-Brokamp, J Yu, ... Thorax 78 (1), 85-87, 2023 | 12 | 2023 |
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells BE Himes, K Obraztsova, L Lian, M Shumyatcher, R Rue, ... PLoS One 13 (5), e0197105, 2018 | 11 | 2018 |
CrossTORC and WNTegration in disease: focus on lymphangioleiomyomatosis JF Evans, K Obraztsova, SM Lin, VP Krymskaya International Journal of Molecular Sciences 22 (5), 2233, 2021 | 9 | 2021 |
Inhibition of growth of TSC2-null cells by a PI3K/mTOR inhibitor but not by a selective MNK1/2 inhibitor JF Evans, RW Rue, AR Mukhitov, K Obraztsova, CJ Smith, VP Krymskaya Biomolecules 10 (1), 28, 2019 | 7 | 2019 |
Hyperactive mTORC1 in lung mesenchyme induces endothelial cell dysfunction and pulmonary vascular remodeling SM Lin, R Rue, AR Mukhitov, A Goel, MC Basil, K Obraztsova, A Babu, ... The Journal of Clinical Investigation 134 (4), 2024 | 4 | 2024 |
Syndecan-2: old player in a new field K Obraztsova, J Evans, VP Krymskaya American Journal of Respiratory Cell and Molecular Biology 60 (6), 611-612, 2019 | 4 | 2019 |
Alveolar fibroblast activation and epithelial injury/repair in pulmonary lymphangioleiomyomatosis (LAM) V Krymskaya, K Obraztsova, A Mukhitov, R Rue, A Goel, A Babu, ... European Respiratory Journal 62 (suppl 67), 2023 | 1 | 2023 |
Aberrant Pulmonary Endothelial Cell Angiogenesis Driven by Constitutive Mesenchymal mTOR Activation S Lin, R Rue, A Goel, K Obraztsova, A Mukhitov, KS Vanka, JF Evans, ... C26. UNRAVELING THE GORDIAN KNOT: MULTI-DIMENSIONAL-OMICs AND SIGNALING …, 2023 | | 2023 |
Dysfunctional Alveolar Repair and Pro-fibrotic Remodeling in Lymphangioleiomyomatosis (LAM) K Obraztsova, AR Mukhitov, R Rue, SM Lin, M Basil, J Carl, M Morley, ... D108. CELLS, SIGNALING, AND MEDIATORS IN LUNG REMODELING AND FIBROSIS, A6769 …, 2023 | | 2023 |
Hyperactive mTOR in Lung Mesenchyme Induces Endothelial Dysfunction and Pulmonary Vascular Remodeling SM Lin, R Rue, A Goel, K Obraztsova, AR Mukhitov, KS Vanka, CJ Smith, ... bioRxiv, 2022.10. 08.511300, 2022 | | 2022 |
WNT-Dependent Lung Fibroblast Activation in Pulmonary Lymphangioleiomyomatosis (LAM) K Obraztsova, AR Mukhitov, S Lin, MC Basil, J Carl, M Morley, A Babu, ... D18. NEW INSIGHTS IN FIBROBLAST BIOLOGY AND PULMONARY FIBROSIS, A5058-A5058, 2022 | | 2022 |
R-spondin 3 Alters Endothelial Cell Function and Contributes to Pulmonary Vascular Remodeling in Hyperactive mTOR Lung Diseases S Lin, R Rue, K Obraztsova, A Mukhitov, C Smith, J Evans, VP Krymskaya D106. NOE VALLEY: CLOTS, COVID, AND LUNG VASCULAR DISEASES, A5432-A5432, 2022 | | 2022 |
Pulmonary Vascular Remodeling: mTOR Activation in Lung Mesenchyme Dysregulates Microvascular Endothelial Transcriptome S Lin, K Obraztsova, AR Mukhitov, R Rue, C Smith, JF Evans, ... TP84. TP084 EIGHT DAYS A WEEK-CELL TYPE-SPECIFIC MECHANISMS OF THE …, 2021 | | 2021 |
Upregulation of WNT Signaling in Lung Epithelial-Mesenchymal Crosstalk May Contribute to the Cystic Remodeling in Pulmonary Lymphangioleiomyomatosis (LAM) K Obraztsova, AR Mukhitov, SM Lin, C Smith, MC Basil, J Katzen, J Carl, ... TP108. TP108 CYSTIC FIBROSIS, LAM, SARCOID, AND RARE DISEASES, A4255-A4255, 2021 | | 2021 |
Abnormal Alveolar Architecture in Lymphangioleiomyomatosis (LAM) Lungs Is a Result of Defective Epithelial-Mesenchymal Crosstalk K Obraztsova, A Mukhitov, MC Basil, J Katzen, J Carl, MF Beers, ... A65. EPITHELIAL CELL BIOLOGY: THE PLOT THICKENS, A2308-A2308, 2020 | | 2020 |
ChIP protocol K Obraztsova | | 2018 |