| Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression AG Henry, S Aghamohammadzadeh, H Samaroo, Y Chen, K Mou, ... Human molecular genetics 24 (21), 6013-6028, 2015 | 239 | 2015 |
| Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice JC Ullman, A Arguello, JA Getz, A Bhalla, CS Mahon, J Wang, T Giese, ... Science Translational Medicine 12 (545), eaay1163, 2020 | 176 | 2020 |
| Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease D Jennings, S Huntwork-Rodriguez, AG Henry, JC Sasaki, R Meisner, ... Science translational medicine 14 (648), eabj2658, 2022 | 168 | 2022 |
| Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ... Cell 184 (18), 4651-4668. e25, 2021 | 161 | 2021 |
| Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway GA Yudowski, MA Puthenveedu, AG Henry, M von Zastrow Molecular biology of the cell 20 (11), 2774-2784, 2009 | 126 | 2009 |
| LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits MAS Baptista, K Merchant, T Barrett, S Bhargava, DK Bryce, JM Ellis, ... Science translational medicine 12 (540), eaav0820, 2020 | 121 | 2020 |
| Regulation of endocytic clathrin dynamics by cargo ubiquitination AG Henry, JN Hislop, J Grove, K Thorn, M Marsh, M von Zastrow Developmental cell 23 (3), 519-532, 2012 | 114 | 2012 |
| Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes JN Hislop, AG Henry, A Marchese, M von Zastrow Journal of Biological Chemistry 284 (29), 19361-19370, 2009 | 105 | 2009 |
| The role of ubiquitination in lysosomal trafficking of δ‐opioid receptors AG Henry, IJ White, M Marsh, M von Zastrow, JN Hislop Traffic 12 (2), 170-184, 2011 | 87 | 2011 |
| Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme A Arguello, CS Mahon, MEK Calvert, D Chan, JC Dugas, ME Pizzo, ... Journal of Experimental Medicine 219 (3), 2022 | 63 | 2022 |
| LRRK2 inhibition by BIIB122 in healthy participants and patients with Parkinson's disease D Jennings, S Huntwork‐Rodriguez, MFJM Vissers, VM Daryani, D Diaz, ... Movement Disorders 38 (3), 386-398, 2023 | 51 | 2023 |
| Ubiquitination in the first cytoplasmic loop of μ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation JN Hislop, AG Henry, M von Zastrow Journal of Biological Chemistry 286 (46), 40193-40204, 2011 | 47 | 2011 |
| Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10 X Wang, E Negrou, MT Maloney, VV Bondar, SV Andrews, M Montalban, ... Scientific Reports 11 (1), 12900, 2021 | 45 | 2021 |
| Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons W Shen, AG Henry, KL Paumier, L Li, K Mou, J Dunlop, Z Berger, ... Journal of neurochemistry 129 (5), 884-894, 2014 | 45 | 2014 |
| Two Regulatory Mechanisms of Monoterpenoid Pheromone Production in Ips spp. Of Bark Beetles JC Bearfield, AG Henry, C Tittiger, GJ Blomquist, MD Ginzel Journal of Chemical Ecology 35, 689-697, 2009 | 32 | 2009 |
| Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome A Arguello, R Meisner, ER Thomsen, HN Nguyen, R Ravi, J Simms, I Lo, ... JCI insight 6 (19), e145445, 2021 | 19 | 2021 |
| Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes X Wang, VV Bondar, OB Davis, MT Maloney, M Agam, MY Chin, ACN Ho, ... Elife 12, e87255, 2023 | 17 | 2023 |
| The genetic drivers of juvenile, young, and early‐onset Parkinson's disease in India SV Andrews, PL Kukkle, R Menon, TS Geetha, V Goyal, RM Kandadai, ... Movement Disorders 39 (2), 339-349, 2024 | 16 | 2024 |
| High-throughput liquid chromatography–tandem mass spectrometry quantification of glycosaminoglycans as biomarkers of mucopolysaccharidosis II J Wang, A Bhalla, JC Ullman, M Fang, R Ravi, A Arguello, E Thomsen, ... International Journal of Molecular Sciences 21 (15), 5449, 2020 | 14 | 2020 |
| A Fixable Fluorescence‐Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells S Zhu, MC Deen, Y Zhu, PA Gilormini, X Chen, OB Davis, MY Chin, ... Angewandte Chemie 135 (40), e202309306, 2023 | 9 | 2023 |
