Các bài viết có thể truy cập công khai - Matthias P. WymannTìm hiểu thêm
Không có ở bất kỳ nơi nào: 5
PQR309 is a novel dual PI3K/mTOR inhibitor with preclinical antitumor activity in lymphomas as a single agent and in combination therapy
C Tarantelli, E Gaudio, AJ Arribas, I Kwee, P Hillmann, A Rinaldi, ...
Clinical Cancer Research 24 (1), 120-129, 2018
Các cơ quan ủy nhiệm: Swiss National Science Foundation, European Commission
PI3Kγ adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns (3, 4, 5) P3 pools in mast cells
T Bohnacker, R Marone, E Collmann, R Calvez, E Hirsch, MP Wymann
Science signaling 2 (74), ra27-ra27, 2009
Các cơ quan ủy nhiệm: Swiss National Science Foundation
A class of highly selective inhibitors bind to an active state of PI3Kγ
G Gangadhara, G Dahl, T Bohnacker, R Rae, J Gunnarsson, S Blaho, ...
Nature chemical biology 15 (4), 348-357, 2019
Các cơ quan ủy nhiệm: Swiss National Science Foundation, UK Medical Research Council
The Chemical Biology of Phosphoinositide 3‐Kinases
MP Wymann, C Schultz
ChemBioChem 13 (14), 2022-2035, 2012
Các cơ quan ủy nhiệm: Swiss National Science Foundation, German Research Foundation
Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP
C Schmidt, N Schneble, JP Müller, R Bauer, A Perino, R Marone, ...
Neuroscience 233, 44-53, 2013
Các cơ quan ủy nhiệm: German Research Foundation
Có tại một số nơi: 54
Lipid signalling in disease
MP Wymann, R Schneiter
Nature reviews Molecular cell biology 9 (2), 162-176, 2008
Các cơ quan ủy nhiệm: Swiss National Science Foundation
Targeting phosphoinositide 3-kinase—moving towards therapy
R Marone, V Cmiljanovic, B Giese, MP Wymann
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1784 (1), 159-185, 2008
Các cơ quan ủy nhiệm: Swiss National Science Foundation
Phosphoinositide 3-kinase p110β activity: key role in metabolism and mammary gland cancer but not development
E Ciraolo, M Iezzi, R Marone, S Marengo, C Curcio, C Costa, O Azzolino, ...
Science signaling 1 (36), ra3-ra3, 2008
Các cơ quan ủy nhiệm: Swiss National Science Foundation, US National Institutes of Health
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ
A Perino, A Ghigo, E Ferrero, F Morello, G Santulli, GS Baillie, F Damilano, ...
Molecular cell 42 (1), 84-95, 2011
Các cơ quan ủy nhiệm: US National Institutes of Health, Fondazione Telethon, Italy
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression
RCY Hui, AR Gomes, D Constantinidou, JR Costa, CT Karadedou, ...
Molecular and cellular biology 28 (19), 5886-5898, 2008
Các cơ quan ủy nhiệm: Cancer Research UK
Genetic and pharmacological targeting of phosphoinositide 3-kinase-γ reduces atherosclerosis and favors plaque stability by modulating inflammatory processes
A Fougerat, S Gayral, P Gourdy, A Schambourg, T Rückle, MK Schwarz, ...
Circulation 117 (10), 1310-1317, 2008
Các cơ quan ủy nhiệm: Swiss National Science Foundation, National Institute of Health and Medical …
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
S Santos‐Sierra, SD Deshmukh, J Kalnitski, P Küenzi, MP Wymann, ...
The EMBO journal 28 (14), 2018-2027, 2009
Các cơ quan ủy nhiệm: Swiss National Science Foundation, US National Institutes of Health, German …
Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors
R Marone, D Erhart, AC Mertz, T Bohnacker, C Schnell, V Cmiljanovic, ...
Molecular Cancer Research 7 (4), 601-613, 2009
Các cơ quan ủy nhiệm: Swiss National Science Foundation
5-(4, 6-Dimorpholino-1, 3, 5-triazin-2-yl)-4-(trifluoromethyl) pyridin-2-amine (PQR309), a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor as …
F Beaufils, N Cmiljanovic, V Cmiljanovic, T Bohnacker, A Melone, ...
Journal of medicinal chemistry 60 (17), 7524-7538, 2017
Các cơ quan ủy nhiệm: Swiss National Science Foundation, UK Medical Research Council, European …
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1–PI3Kγ pathway
S Gayral, R Garnotel, A Castaing-Berthou, S Blaise, A Fougerat, E Berge, ...
Cardiovascular research 102 (1), 118-127, 2014
Các cơ quan ủy nhiệm: Fonds de recherche du Québec - Santé, National Institute of Health and …
Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
T Bohnacker, AE Prota, F Beaufils, JE Burke, A Melone, AJ Inglis, ...
Nature communications 8 (1), 14683, 2017
Các cơ quan ủy nhiệm: Swiss National Science Foundation, British Heart Foundation, UK Medical …
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
B Kurig, A Shymanets, T Bohnacker, Prajwal, C Brock, MR Ahmadian, ...
Proceedings of the National Academy of Sciences 106 (48), 20312-20317, 2009
Các cơ quan ủy nhiệm: Swiss National Science Foundation, US National Institutes of Health, German …
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature
CA Reichel, M Lerchenberger, B Uhl, M Rehberg, N Berberich, S Zahler, ...
PloS one 6 (2), e17229, 2011
Các cơ quan ủy nhiệm: German Research Foundation
Essential role of the p110β subunit of phosphoinositide 3-OH kinase in male fertility
E Ciraolo, F Morello, RM Hobbs, F Wolf, R Marone, M Iezzi, X Lu, ...
Molecular biology of the cell 21 (5), 704-711, 2010
Các cơ quan ủy nhiệm: US National Institutes of Health
Discovery and Preclinical Characterization of 5-[4, 6-Bis ({3-oxa-8-azabicyclo [3.2. 1] octan-8-yl})-1, 3, 5-triazin-2-yl]-4-(difluoromethyl) pyridin-2-amine (PQR620), a Highly …
D Rageot, T Bohnacker, A Melone, JB Langlois, C Borsari, P Hillmann, ...
Journal of medicinal chemistry 61 (22), 10084-10105, 2018
Các cơ quan ủy nhiệm: Swiss National Science Foundation, European Commission
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