The anaplastic lymphoma kinase in the pathogenesis of cancer R Chiarle, C Voena, C Ambrogio, R Piva, G Inghirami Nature Reviews Cancer 8 (1), 11-23, 2008 | 1076 | 2008 |
KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS C Ambrogio, J Köhler, ZW Zhou, H Wang, R Paranal, J Li, M Capelletti, ... Cell 172 (4), 857-868. e15, 2018 | 288 | 2018 |
Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology RB Blasco, E Karaca, C Ambrogio, TC Cheong, E Karayol, VG Minero, ... Cell reports 9 (4), 1219-1227, 2014 | 252 | 2014 |
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma C Ambrogio, G Gomez-Lopez, M Falcone, A Vidal, E Nadal, N Crosetto, ... Nature medicine 22 (3), 270-277, 2016 | 200 | 2016 |
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas R Piva, R Chiarle, AD Manazza, R Taulli, W Simmons, C Ambrogio, ... Blood 107 (2), 689-697, 2006 | 177 | 2006 |
Potent and selective covalent quinazoline inhibitors of KRAS G12C M Zeng, J Lu, L Li, F Feru, C Quan, TW Gero, SB Ficarro, Y Xiong, ... Cell chemical biology 24 (8), 1005-1016. e3, 2017 | 152 | 2017 |
MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling P Gonzalo, MC Guadamillas, MV Hernández-Riquer, Á Pollán, ... Developmental cell 18 (1), 77-89, 2010 | 142 | 2010 |
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination R Chiarle, C Martinengo, C Mastini, C Ambrogio, V D'escamard, G Forni, ... Nature medicine 14 (6), 676-680, 2008 | 142 | 2008 |
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells M Compagno, Q Wang, C Pighi, TC Cheong, FL Meng, T Poggio, ... Nature 542 (7642), 489-493, 2017 | 139 | 2017 |
The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration C Voena, C Conte, C Ambrogio, E Boeri Erba, F Boccalatte, S Mohammed, ... Cancer research 67 (9), 4278-4286, 2007 | 129 | 2007 |
A Braf kinase-inactive mutant induces lung adenocarcinoma P Nieto, C Ambrogio, L Esteban-Burgos, G Gómez-López, MT Blasco, ... Nature 548 (7666), 239-243, 2017 | 117 | 2017 |
Impact of BRAF mutation class on disease characteristics and clinical outcomes in BRAF-mutant lung cancer I Dagogo-Jack, P Martinez, BY Yeap, C Ambrogio, LA Ferris, C Lydon, ... Clinical Cancer Research 25 (1), 158-165, 2019 | 116 | 2019 |
NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells C Ambrogio, C Martinengo, C Voena, F Tondat, L Riera, PF di Celle, ... Cancer research 69 (22), 8611-8619, 2009 | 116 | 2009 |
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy M Holderfield, BJ Lee, J Jiang, A Tomlinson, KJ Seamon, A Mira, ... Nature 629 (8013), 919-926, 2024 | 109 | 2024 |
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase C Ambrogio, C Voena, AD Manazza, R Piva, L Riera, L Barberis, C Costa, ... Blood 106 (12), 3907-3916, 2005 | 103 | 2005 |
Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner N Crosetto, M Bienko, RG Hibbert, T Perica, C Ambrogio, T Kensche, ... Journal of biological chemistry 283 (50), 35173-35185, 2008 | 84 | 2008 |
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice AJ Lopez-Contreras, J Specks, JH Barlow, C Ambrogio, C Desler, ... Genes & development 29 (7), 690-695, 2015 | 82 | 2015 |
Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights Y Kobayashi, C Ambrogio, T Mitsudomi Translational lung cancer research 7 (4), 487, 2018 | 80 | 2018 |
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma M Menotti, C Ambrogio, TC Cheong, C Pighi, I Mota, SH Cassel, ... Nature medicine 25 (1), 130-140, 2019 | 77 | 2019 |
Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma D Di Paolo, C Ambrogio, F Pastorino, C Brignole, C Martinengo, ... Molecular Therapy 19 (12), 2201-2212, 2011 | 77 | 2011 |