Theo dõi
Joseph W. Lewcock
Joseph W. Lewcock
CSO and Head of Discovery, Denali Therapeutics
Email được xác minh tại dnli.com
Tiêu đề
Trích dẫn bởi
Trích dẫn bởi
Năm
TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge
AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ...
Neuron 105 (5), 837-854. e9, 2020
5212020
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
TA Watkins, B Wang, S Huntwork-Rodriguez, J Yang, Z Jiang, ...
Proceedings of the National Academy of Sciences 110 (10), 4039-4044, 2013
3302013
A feedback mechanism regulates monoallelic odorant receptor expression
JW Lewcock, RR Reed
Proceedings of the National Academy of Sciences 101 (4), 1069-1074, 2004
3152004
Small-molecule modulation of TDP-43 recruitment to stress granules prevents persistent TDP-43 accumulation in ALS/FTD
MY Fang, S Markmiller, AQ Vu, A Javaherian, WE Dowdle, P Jolivet, ...
Neuron 103 (5), 802-819. e11, 2019
2452019
Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ...
EMBO molecular medicine 12 (4), e11227, 2020
2442020
The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics
JW Lewcock, N Genoud, K Lettieri, SL Pfaff
Neuron 56 (4), 604-620, 2007
2382007
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
A Sengupta Ghosh, B Wang, CD Pozniak, M Chen, RJ Watts, JW Lewcock
Journal of Cell Biology 194 (5), 751-764, 2011
2372011
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia
BJ Andreone, L Przybyla, C Llapashtica, A Rana, SS Davis, ...
Nature neuroscience 23 (8), 927-938, 2020
2032020
Emerging microglia biology defines novel therapeutic approaches for Alzheimer’s disease
JW Lewcock, K Schlepckow, G Di Paolo, S Tahirovic, KM Monroe, ...
Neuron 108 (5), 801-821, 2020
2022020
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits
CP Myers, JW Lewcock, MG Hanson, S Gosgnach, JB Aimone, FH Gage, ...
Neuron 46 (1), 37-49, 2005
1712005
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection
SS Wang, JW Lewcock, P Feinstein, P Mombaerts, RR Reed
Oxford University Press for The Company of Biologists Limited 131 (6), 1377-1388, 2004
1632004
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
S Huntwork-Rodriguez, B Wang, T Watkins, AS Ghosh, CD Pozniak, ...
Journal of Cell Biology 202 (5), 747-763, 2013
1622013
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
T Logan, MJ Simon, A Rana, GM Cherf, A Srivastava, SS Davis, RLY Low, ...
Cell 184 (18), 4651-4668. e25, 2021
1612021
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ...
Nature neuroscience 26 (3), 416-429, 2023
1582023
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
CE Le Pichon, WJ Meilandt, S Dominguez, H Solanoy, H Lin, H Ngu, ...
Science translational medicine 9 (403), eaag0394, 2017
1442017
FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code
R Shirasaki, JW Lewcock, K Lettieri, SL Pfaff
Neuron 50 (6), 841-853, 2006
1402006
Presenilin-dependent receptor processing is required for axon guidance
G Bai, O Chivatakarn, D Bonanomi, K Lettieri, L Franco, C Xia, E Stein, ...
Cell 144 (1), 106-118, 2011
1382011
Leveraging preclinical models for the development of Alzheimer disease therapeutics
K Scearce-Levie, PE Sanchez, JW Lewcock
Nature reviews drug discovery 19 (7), 447-462, 2020
1032020
Cell death and neurodegeneration
BJ Andreone, M Larhammar, JW Lewcock
Cold Spring Harbor perspectives in biology 12 (2), a036434, 2020
992020
The Ste20 family kinases MAP4K4, MINK1, and TNIK converge to regulate stress-induced JNK signaling in neurons
M Larhammar, S Huntwork-Rodriguez, Y Rudhard, A Sengupta-Ghosh, ...
Journal of Neuroscience 37 (46), 11074-11084, 2017
972017
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