| Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target YJ Yu, Y Zhang, M Kenrick, K Hoyte, W Luk, Y Lu, J Atwal, JM Elliott, ... Science translational medicine 3 (84), 84ra44-84ra44, 2011 | 862 | 2011 |
| Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds BJ Aragona, Y Liu, YJ Yu, JT Curtis, JM Detwiler, TR Insel, Z Wang Nature neuroscience 9 (1), 133-139, 2006 | 604 | 2006 |
| Soluble Dendron-Functionalized Carbon Nanotubes: Preparation, Characterization, and Properties, YP Sun, W Huang, Y Lin, K Fu, A Kitaygorodskiy, LA Riddle, YJ Yu, ... Chemistry of Materials 13 (9), 2864-2869, 2001 | 491 | 2001 |
| Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ... Science translational medicine 6 (261), 261ra154-261ra154, 2014 | 391 | 2014 |
| Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants N Bien-Ly, YJ Yu, D Bumbaca, J Elstrott, CA Boswell, Y Zhang, W Luk, ... Journal of Experimental Medicine 211 (2), 233-244, 2014 | 355 | 2014 |
| Effector-attenuating substitutions that maintain antibody stability and reduce toxicity in mice M Lo, HS Kim, RK Tong, TW Bainbridge, JM Vernes, Y Zhang, YL Lin, ... Journal of Biological Chemistry 292 (9), 3900-3908, 2017 | 295 | 2017 |
| Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier JA Couch, YJ Yu, Y Zhang, JM Tarrant, RN Fuji, WJ Meilandt, H Solanoy, ... Science translational medicine 5 (183), 183ra57-183ra57, 2013 | 282 | 2013 |
| Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies YJY Zuchero, X Chen, N Bien-Ly, D Bumbaca, RK Tong, X Gao, S Zhang, ... Neuron 89 (1), 70-82, 2016 | 278 | 2016 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... Science translational medicine 12 (545), eaay1359, 2020 | 273 | 2020 |
| Developing therapeutic antibodies for neurodegenerative disease YJ Yu, RJ Watts Neurotherapeutics 10 (3), 459-472, 2013 | 242 | 2013 |
| Morphine promotes rapid, arrestin-dependent endocytosis of μ-opioid receptors in striatal neurons H Haberstock-Debic, KA Kim, YJ Yu, M von Zastrow Journal of Neuroscience 25 (34), 7847-7857, 2005 | 176 | 2005 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 158 | 2023 |
| Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of μ-opioid receptors in CNS neurons YJ Yu, S Arttamangkul, CJ Evans, JT Williams, M Von Zastrow Journal of Neuroscience 29 (1), 222-233, 2009 | 77 | 2009 |
| Fast modulation of μ-opioid receptor (MOR) recycling is mediated by receptor agonists C Roman-Vendrell, YJ Yu, GA Yudowski Journal of Biological Chemistry 287 (18), 14782-14791, 2012 | 39 | 2012 |
| CD98hc is a target for brain delivery of biotherapeutics KS Chew, RC Wells, A Moshkforoush, D Chan, KJ Lechtenberg, HL Tran, ... nature communications 14 (1), 5053, 2023 | 35 | 2023 |
| Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion YJ Yu, R Dhavan, MW Chevalier, GA Yudowski, M von Zastrow Journal of Neuroscience 30 (35), 11703-11714, 2010 | 35 | 2010 |
| Low affinity blood brain barrier receptor antibodies and uses therefor M Dennis, RJ Watts, YJ Yu, Y Zhang US Patent App. 13/306,524, 2012 | 30 | 2012 |
| Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier SJ Barker, MB Thayer, C Kim, D Tatarakis, MJ Simon, R Dial, L Nilewski, ... Science Translational Medicine 16 (760), eadi2245, 2024 | 29 | 2024 |
| Low affinity blood brain barrier receptor antibodies and uses therefor M Dennis, RJ Watts, YJ Yu, Y Zhang US Patent 9,611,323, 2017 | 24 | 2017 |
| Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys. Sci Transl Med 12: eaay1359 MS Kariolis, RC Wells, JA Getz, W Kwan, CS Mahon, R Tong, DJ Kim, ... | 10 | 2020 |
