| Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism JR Clapper, G Moreno-Sanz, R Russo, A Guijarro, F Vacondio, A Duranti, ... Nature neuroscience 13 (10), 1265-1270, 2010 | 399 | 2010 |
| Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment JR Clapper, MD Hendricks, G Gu, C Wittmer, CS Dolman, J Herich, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 305 (7 …, 2013 | 316 | 2013 |
| Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates Z Justinova, RA Mangieri, M Bortolato, SI Chefer, AG Mukhin, JR Clapper, ... Biological psychiatry 64 (11), 930-937, 2008 | 177 | 2008 |
| Identification of ABX-1431, a selective inhibitor of monoacylglycerol lipase and clinical candidate for treatment of neurological disorders JS Cisar, OD Weber, JR Clapper, JL Blankman, CL Henry, GM Simon, ... Journal of medicinal chemistry 61 (20), 9062-9084, 2018 | 137 | 2018 |
| URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices AR King, A Duranti, A Tontini, S Rivara, A Rosengarth, JR Clapper, ... Chemistry & biology 14 (12), 1357-1365, 2007 | 127 | 2007 |
| The endocannabinoid system as a target for the treatment of cannabis dependence JR Clapper, RA Mangieri, D Piomelli Neuropharmacology 56, 235-243, 2009 | 121 | 2009 |
| 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism KM Jung, JR Clapper, J Fu, G D'Agostino, A Guijarro, D Thongkham, ... Cell metabolism 15 (3), 299-310, 2012 | 112 | 2012 |
| A second generation of carbamate‐based fatty acid amide hydrolase inhibitors with improved activity in vivo JR Clapper, F Vacondio, AR King, A Duranti, A Tontini, C Silva, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (9), 1505-1513, 2009 | 94 | 2009 |
| Synthesis and quantitative structure− activity relationship of fatty acid amide hydrolase inhibitors: Modulation at the N-portion of biphenyl-3-yl alkylcarbamates M Mor, A Lodola, S Rivara, F Vacondio, A Duranti, A Tontini, S Sanchini, ... Journal of medicinal chemistry 51 (12), 3487-3498, 2008 | 78 | 2008 |
| A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy SA Eisenstein, JR Clapper, PV Holmes, D Piomelli, AG Hohmann Pharmacological research 61 (5), 419-429, 2010 | 60 | 2010 |
| Structure–Property Relationships of a Class of Carbamate‐Based Fatty Acid Amide Hydrolase (FAAH) Inhibitors: Chemical and Biological Stability F Vacondio, C Silva, A Lodola, A Fioni, S Rivara, A Duranti, A Tontini, ... ChemMedChem: Chemistry Enabling Drug Discovery 4 (9), 1495-1504, 2009 | 54 | 2009 |
| Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models JR Clapper, J Athanacio, C Wittmer, PS Griffin, L D'Souza, DG Parkes, ... European journal of pharmacology 698 (1-3), 292-298, 2013 | 40 | 2013 |
| Monoacylglycerol lipase inhibition in human and rodent systems supports clinical evaluation of endocannabinoid modulators JR Clapper, CL Henry, MJ Niphakis, AM Knize, AR Coppola, GM Simon, ... The Journal of pharmacology and experimental therapeutics 367 (3), 494-508, 2018 | 34 | 2018 |
| The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues JR Clapper, A Duranti, A Tontini, M Mor, G Tarzia, D Piomelli Pharmacological research 54 (5), 341-344, 2006 | 28 | 2006 |
| Identification of a Bioactive Impurity in a Commercial Sample of 6‐Methyl‐2‐p‐Tolylaminobenzo[d][1,3]Oxazin‐4‐One (URB754) G Tarzia, F Antonietti, A Duranti, A Tontini, M Mor, S Rivara, P Traldi, ... Annali di Chimica: Journal of Analytical, Environmental and Cultural …, 2007 | 25 | 2007 |
| Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability F Vacondio, C Silva, A Lodola, C Carmi, S Rivara, A Duranti, A Tontini, ... European journal of medicinal chemistry 46 (9), 4466-4473, 2011 | 23 | 2011 |
| Methods of treating inflammation or neuropathic pain JL Blankman, JR Clapper, RAB EZEKOWITZ, IP Fraser, CA Grice, ... US Patent App. 17/227,072, 2021 | 10 | 2021 |
| Methods of treating inflammation or neuropathic pain JL Blankman, JR Clapper, RAB EZEKOWITZ, IP Fraser, CA Grice, ... US Patent 10,450,302, 2019 | 9 | 2019 |
| Methods of treating inflammation or neuropathic pain JL Blankman, JR Clapper, RAB EZEKOWITZ, IP Fraser, CA Grice, ... US Patent 11,034,674, 2021 | 7 | 2021 |
| Preclinical characterization and first-in-human administration of a selective monoacylglycerol lipase inhibitor, ABX-1431 IP Fraser, J Blankman, J Clapper, C Grice, G O’Neill, A Ezekowitz, ... Conference Abstract: EUFEMED 201710, 2017 | 4 | 2017 |
