Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation JS Scott, AM Birch, KJ Brocklehurst, A Broo, HS Brown, RJ Butlin, ... Journal of Medicinal Chemistry 55 (11), 5361-5379, 2012 | 81 | 2012 |
Toward Solution-State Structure. A 6Li, 1H HOESY NMR, X-ray Diffraction, Semiempirical (PM3, MNDO), and ab Initio Computational Study of a Chiral Lithium Amide G Hilmersson, PI Arvidsson, Ö Davidsson, M Håkansson Journal of the American Chemical Society 120 (32), 8143-8149, 1998 | 74 | 1998 |
Rational Design of Chiral Lithium Amides for Asymmetric Alkylation Reactions—NMR Spectroscopic Studies of Mixed Lithium Amide/Alkyllithium Complexes PI Arvidsson, G Hilmersson, Ö Davidsson Chemistry–A European Journal 5 (8), 2348-2355, 1999 | 70 | 1999 |
The Use of 15N NMR Spectroscopy To Resolve the “Higher Order Cyanocuprate” Controversy: 15N, 6Li, and 13C NMR Spectroscopic Investigations of CuCN … SH Bertz, K Nilsson, Ö Davidsson, JP Snyder Angewandte Chemie International Edition 37 (3), 314-317, 1998 | 65 | 1998 |
Enantioselective butylation of aliphatic aldehydes by mixed chiral lithium amide/n-BuLi dimers PI Arvidsson, Ö Davidsson, G Hilmersson Tetrahedron: Asymmetry 10 (3), 527-534, 1999 | 63 | 1999 |
Chiral Lithium Amide/Solute Complexes: X-ray Crystallographic and NMR Spectroscopic Studies G Hilmersson, PI Arvidsson, Ö Davidsson, M Håkansson Organometallics 16 (15), 3352-3362, 1997 | 63 | 1997 |
Recent advances for FLAP inhibitors D Pettersen, Ö Davidsson, C Whatling Bioorganic & medicinal chemistry letters 25 (13), 2607-2612, 2015 | 55 | 2015 |
Identification and design of a novel series of MGAT2 inhibitors JG Barlind, LK Buckett, SG Crosby, Ö Davidsson, H Emtenäs, A Ertan, ... Bioorganic & Medicinal Chemistry Letters 23 (9), 2721-2726, 2013 | 51 | 2013 |
6Li and (15) N NMR Data as a Probe for the Influence of Solvent and Intramolecular Solvation on the Solution-State Structures of Chiral Lithium Amides The authors are most … PI Arvidsson, Ö Davidsson Angewandte Chemie (International ed. in English) 39 (8), 1467-1470, 2000 | 50 | 2000 |
Solution structure of a dilithiumamide/diethylzinc heterocomplex that catalyzes asymmetric alkylation reactions J Eriksson, PI Arvidsson, Ö Davidsson Chemistry–A European Journal 5 (8), 2356-2361, 1999 | 45 | 1999 |
Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases M Lemurell, J Ulander, S Winiwarter, A Dahlen, O Davidsson, ... Journal of Medicinal Chemistry 58 (2), 897-911, 2015 | 41 | 2015 |
A Novel Mixed Dimer of a Norephedrine‐Derived Chiral Lithium Amide and 2‐Lithium‐1‐methylimidazole, and Catalytic Enantioselective Deprotonation of Cyclohexene Oxide M Amedjkouh, D Pettersen, SO Nilsson Lill, Ö Davidsson, P Ahlberg Chemistry–A European Journal 7 (20), 4368-4377, 2001 | 40 | 2001 |
Octahedral Grignard reagents can be chiral at magnesium M Vestergren, B Gustafsson, Ö Davidsson, M Håkansson Angewandte Chemie 112 (19), 3577-3579, 2000 | 39 | 2000 |
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats C Bengtsson, S Blaho, DB Saitton, K Brickmann, J Broddefalk, ... Bioorganic & medicinal chemistry 19 (10), 3039-3053, 2011 | 37 | 2011 |
Enantiomeric Perturbation of Equilibria. Differential Solvation of a Chiral Lithium Amide by the Enantiomers of 2-Methyltetrahydrofuran Measured by NMR Spectroscopy G Hilmersson, P Ahlberg, Ö Davidsson Journal of the American Chemical Society 118 (14), 3539-3540, 1996 | 37 | 1996 |
Solution structure of a key intermediate used in asymmetric alkylation reactions. 1H, 1H-NOESY and 6Li, 1H-HOESY studies of mixtures of a chiral lithium amide and n-butyllithium G Hilmersson, Ö Davidsson Journal of organometallic chemistry 489 (1-2), 175-179, 1995 | 36 | 1995 |
Cyano‐Gilman‐Reagentien oder Cyanocuprate höherer Ordnung? 15N‐, 6Li‐und 13C‐NMR‐spektroskopische Untersuchungen an BuCu (CN) Li und Bu2CuLi⋅ LiCN SH Bertz, K Nilsson, Ö Davidsson, JP Snyder Angewandte Chemie 110 (3), 327-331, 1998 | 35 | 1998 |
Solid-phase supported chiral lithium amides used in deprotonation reactions A Johansson, P Abrahamsson, Ö Davidsson Tetrahedron: Asymmetry 14 (10), 1261-1266, 2003 | 34 | 2003 |
Isoindolinone compounds active as Kv1. 5 blockers identified using a multicomponent reaction approach J Kajanus, I Jacobson, A Åstrand, RI Olsson, U Gran, A Björe, O Fjellström, ... Bioorganic & medicinal chemistry letters 26 (8), 2023-2029, 2016 | 24 | 2016 |
A new chiral lithium amide based on (S)-2-[1-(3, 3-dimethyl) pyrrolidinylmethyl] pyrrolidine—synthesis, NMR studies and use in the enantioselective deprotonation of … AZQ Khan, RW de Groot, PI Arvidsson, Ö Davidsson Tetrahedron: Asymmetry 9 (7), 1223-1229, 1998 | 20 | 1998 |