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| Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus P Liu, M Begley, W Michowski, H Inuzuka, M Ginzberg, D Gao, P Tsou, ... Nature 508 (7497), 541-545, 2014 | 402 | 2014 |
| Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function A Papa, L Wan, M Bonora, L Salmena, MS Song, RM Hobbs, A Lunardi, ... Cell 157 (3), 595-610, 2014 | 321 | 2014 |
| RAF-MEK-ERK pathway in cancer evolution and treatment R Ullah, Q Yin, AH Snell, L Wan Seminars in cancer biology 85, 123-154, 2022 | 316 | 2022 |
| Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis P Liu, W Gan, H Inuzuka, AS Lazorchak, D Gao, O Arojo, D Liu, L Wan, ... Nature cell biology 15 (11), 1340-1350, 2013 | 307 | 2013 |
| mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR D Gao, H Inuzuka, MKM Tan, H Fukushima, JW Locasale, P Liu, L Wan, ... Molecular cell 44 (2), 290-303, 2011 | 283 | 2011 |
| Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway YR Lee, M Chen, JD Lee, J Zhang, SY Lin, TM Fu, H Chen, T Ishikawa, ... Science 364 (6441), eaau0159, 2019 | 274 | 2019 |
| Targeting Cdc20 as a novel cancer therapeutic strategy L Wang, J Zhang, L Wan, X Zhou, Z Wang, W Wei Pharmacology & therapeutics 151, 141-151, 2015 | 247 | 2015 |
| Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase H Inuzuka, A Tseng, D Gao, B Zhai, Q Zhang, S Shaik, L Wan, XL Ang, ... Cancer cell 18 (2), 147-159, 2010 | 243 | 2010 |
| Acetylation-dependent regulation of Skp2 function H Inuzuka, D Gao, LWS Finley, W Yang, L Wan, H Fukushima, YR Chin, ... Cell 150 (1), 179-193, 2012 | 234 | 2012 |
| Phosphorylation of EZH2 by AMPK suppresses PRC2 methyltransferase activity and oncogenic function L Wan, K Xu, Y Wei, J Zhang, T Han, C Fry, Z Zhang, YV Wang, L Huang, ... Molecular cell 69 (2), 279-291. e5, 2018 | 190 | 2018 |
| Tumor suppressor functions of FBW7 in cancer development and progression Z Wang, H Inuzuka, J Zhong, L Wan, H Fukushima, FH Sarkar, W Wei FEBS letters 586 (10), 1409-1418, 2012 | 183 | 2012 |
| MC1R is a potent regulator of PTEN after UV exposure in melanocytes J Cao, L Wan, E Hacker, X Dai, S Lenna, C Jimenez-Cervantes, Y Wang, ... Molecular cell 51 (4), 409-422, 2013 | 173 | 2013 |
| Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade X Dai, X Bu, Y Gao, J Guo, J Hu, C Jiang, Z Zhang, K Xu, J Duan, S He, ... Molecular cell 81 (11), 2317-2331. e6, 2021 | 157 | 2021 |
| APCCdc20 suppresses apoptosis through targeting Bim for ubiquitination and destruction L Wan, M Tan, J Yang, H Inuzuka, X Dai, T Wu, J Liu, S Shaik, G Chen, ... Developmental cell 29 (4), 377-391, 2014 | 149 | 2014 |
| Skp2: a novel potential therapeutic target for prostate cancer Z Wang, D Gao, H Fukushima, H Inuzuka, P Liu, L Wan, FH Sarkar, W Wei Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1825 (1), 11-17, 2012 | 144 | 2012 |
| Cdc20: a potential novel therapeutic target for cancer treatment Z Wang, L Wan, J Zhong, H Inuzuka, P Liu, FH Sarkar, W Wei Current pharmaceutical design 19 (18), 3210-3214, 2013 | 136 | 2013 |
| Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction D Gao, L Wan, H Inuzuka, AH Berg, A Tseng, B Zhai, S Shaik, E Bennett, ... Molecular cell 39 (5), 797-808, 2010 | 115 | 2010 |
| Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1 L Wan, W Zou, D Gao, H Inuzuka, H Fukushima, AH Berg, R Drapp, ... Molecular cell 44 (5), 721-733, 2011 | 111 | 2011 |
| Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis J Zhang, L Wan, X Dai, Y Sun, W Wei Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1845 (2), 277-293, 2014 | 110 | 2014 |
