| Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism … NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ... Drug metabolism reviews 39 (1), 159-234, 2007 | 868 | 2007 |
| Screening for human ADME/Tox drug properties in drug discovery AP Li Drug discovery today 6 (7), 357-366, 2001 | 719 | 2001 |
| A simplified method for production and growth of multicellular tumor spheroids JM Yuhas, AP Li, AO Martinez, AJ Ladman Cancer research 37 (10), 3639-3643, 1977 | 692 | 1977 |
| Substrates of human hepatic cytochrome P450 3A4 AP Li, DL Kaminski, A Rasmussen Toxicology 104 (1-3), 1-8, 1995 | 441 | 1995 |
| Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A Y Shitara, T Itoh, H Sato, AP Li, Y Sugiyama The Journal of pharmacology and experimental therapeutics 304 (2), 610-616, 2003 | 428 | 2003 |
| Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability … AP Li, C Lu, JA Brent, C Pham, A Fackett, CE Ruegg, PM Silber Chemico-biological interactions 121 (1), 17-35, 1999 | 373 | 1999 |
| Tissue factor: an enzyme cofactor and a true receptor JH Morrissey Thrombosis and haemostasis 86 (07), 66-74, 2001 | 316 | 2001 |
| Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague–Dawley rat … C Lu, AP Li Chemico-biological interactions 134 (3), 271-281, 2001 | 272 | 2001 |
| Human hepatocytes: isolation, cryopreservation and applications in drug development AP Li Chemico-biological interactions 168 (1), 16-29, 2007 | 258 | 2007 |
| Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes J Easterbrook, C Lu, Y Sakai, AP Li Drug Metabolism and Disposition 29 (2), 141-144, 2001 | 244 | 2001 |
| Primary human hepatocytes as a tool for the evaluation of structure—activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin … AP Li, MK Reith, A Rasmussen, JC Gorski, SD Hall, L Xu, DL Kaminski, ... Chemico-biological interactions 107 (1-2), 17-30, 1997 | 228 | 1997 |
| A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity AP Li Chemico-biological interactions 142 (1-2), 7-23, 2002 | 218 | 2002 |
| Optimization of cryopreservation procedures for rat and human hepatocytes LJ Loretz, AP Li, MW Flye, AGE Wilson Xenobiotica 19 (5), 489-498, 1989 | 208 | 1989 |
| Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel AP Li, PD Gorycki, JG Hengstler, GL Kedderis, HG Koebe, R Rahmani, ... Chemico-biological interactions 121 (1), 117-123, 1999 | 188 | 1999 |
| Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction AP Li, P Maurel, MJ Gomez-Lechon, LC Cheng, M Jurima-Romet Chemico-biological interactions 107 (1-2), 5-16, 1997 | 184 | 1997 |
| 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration H Wang, PC Brown, ECY Chow, L Ewart, SS Ferguson, S Fitzpatrick, ... Clinical and translational science 14 (5), 1659-1680, 2021 | 153 | 2021 |
| A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: comparative cytotoxicity of tamoxifen … AP Li, C Bode, Y Sakai Chemico-biological interactions 150 (1), 129-136, 2004 | 144 | 2004 |
| Function of uptake transporters for taurocholate and estradiol 17β-d-glucuronide in cryopreserved human hepatocytes Y Shitara, AP Li, Y Kato, C Lu, K Ito, T Itoh, Y Sugiyama Drug metabolism and pharmacokinetics 18 (1), 33-41, 2003 | 139 | 2003 |
| Isolation and culturing of hepatocytes from human livers AP Li, MA Roque, DJ Beck, DL Kaminski Journal of tissue culture methods 14, 139-145, 1992 | 134 | 1992 |
| Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro LD Kier, R Neft, L Tang, R Suizu, T Cook, K Onsurez, K Tiegler, Y Sakai, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 549 (1 …, 2004 | 130 | 2004 |