| An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies LA Kelley, SP Gardner, MJ Sutcliffe Protein Engineering, Design and Selection 9 (11), 1063-1065, 1996 | 603 | 1996 |
| Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures MJ Sutcliffe, I Haneef, D Carney, TL Blundell Protein Engineering, Design and Selection 1 (5), 377-384, 1987 | 549 | 1987 |
| Crystal structure of a PDZ domain JHM Cabral, C Petosa, MJ Sutcliffe, S Raza, O Byron, F Poy, SM Marfatia, ... Nature 382 (6592), 649-652, 1996 | 448 | 1996 |
| Atomic description of an enzyme reaction dominated by proton tunneling L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ... Science 312 (5771), 237-241, 2006 | 412 | 2006 |
| Knowledge‐based protein modelling and design T Blundell, D Carney, S Gardner, F Hayes, B Howlin, T Hubbard, ... European Journal of Biochemistry 172 (3), 513-520, 1988 | 364 | 1988 |
| Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains MJ Sutcliffe, FRF Hayes, TL Blundell Protein Engineering, Design and Selection 1 (5), 385-392, 1987 | 337 | 1987 |
| Enzymatic H-transfer requires vibration-driven extreme tunneling J Basran, MJ Sutcliffe, NS Scrutton Biochemistry 38 (10), 3218-3222, 1999 | 293 | 1999 |
| Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ... Insect biochemistry and molecular biology 41 (7), 492-502, 2011 | 283 | 2011 |
| A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1. PR Stanfield, NW Davies, PA Shelton, MJ Sutcliffe, IA Khan, WJ Brammar, ... The Journal of physiology 478 (1), 1-6, 1994 | 243 | 1994 |
| A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ... Biochemistry 35 (14), 4540-4550, 1996 | 225 | 1996 |
| Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit EC Tozer, RC Liddington, MJ Sutcliffe, AH Smeeton, JC Loftus Journal of Biological Chemistry 271 (36), 21978-21984, 1996 | 215 | 1996 |
| A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation CF Oliver, S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts Biochemistry 36 (7), 1567-1572, 1997 | 205 | 1997 |
| TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies M MacFarlane, SL Kohlhaas, MJ Sutcliffe, MJS Dyer, GM Cohen Cancer research 65 (24), 11265-11270, 2005 | 201 | 2005 |
| Biodiversity of cytochrome P450 redox systems KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ... Biochemical Society Transactions 33 (4), 796-801, 2005 | 177 | 2005 |
| A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes MJ Sutcliffe, NS Scrutton European Journal of Biochemistry 269 (13), 3096-3102, 2002 | 176 | 2002 |
| The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts Nature Structural Biology 3 (5), 414-417, 1996 | 171 | 1996 |
| Structure of hen lysozyme in solution LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson Journal of molecular biology 229 (4), 930-944, 1993 | 163 | 1993 |
| Analysis of. vphi. and. chi. 1 torsion angles for hen lysozyme in solution from proton NMR spin-spin coupling constants LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson Biochemistry 30 (4), 986-996, 1991 | 153 | 1991 |
| Drug block of the hERG potassium channel: insight from modeling PJ Stansfeld, P Gedeck, M Gosling, B Cox, JS Mitcheson, MJ Sutcliffe Proteins: Structure, Function, and Bioinformatics 68 (2), 568-580, 2007 | 147 | 2007 |
| Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6 MJI Paine, LA McLaughlin, JU Flanagan, CA Kemp, MJ Sutcliffe, ... Journal of Biological Chemistry 278 (6), 4021-4027, 2003 | 142 | 2003 |
