| Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy E Lonardo, PC Hermann, MT Mueller, S Huber, A Balic, ... Cell stem cell 9 (5), 433-446, 2011 | 465 | 2011 |
| Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system R Torres, MC Martin, A Garcia, JC Cigudosa, JC Ramirez, ... Nature communications 5 (1), 3964, 2014 | 304 | 2014 |
| Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy JC Estrada, Y Torres, A Benguria, A Dopazo, E Roche, ... Cell death & disease 4 (6), e691-e691, 2013 | 272 | 2013 |
| A faecal microbiota signature with high specificity for pancreatic cancer E Kartal, TSB Schmidt, E Molina-Montes, S Rodríguez-Perales, J Wirbel, ... Gut 71 (7), 1359-1372, 2022 | 198 | 2022 |
| CRISPR/Cas9 for cancer therapy: hopes and challenges M Martinez-Lage, P Puig-Serra, P Menendez, R Torres-Ruiz, ... Biomedicines 6 (4), 105, 2018 | 146 | 2018 |
| Immune profiling and quantitative analysis decipher the clinical role of immune-checkpoint expression in the tumor immune microenvironment of DLBCL ZY Xu-Monette, M Xiao, Q Au, R Padmanabhan, B Xu, N Hoe, ... Cancer immunology research 7 (4), 644-657, 2019 | 144 | 2019 |
| Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism S García-Silva, A Benito-Martín, L Nogués, A Hernández-Barranco, ... Nature Cancer 2 (12), 1387-1405, 2021 | 123 | 2021 |
| Clinically relevant correction of recessive dystrophic epidermolysis bullosa by dual sgRNA CRISPR/Cas9-mediated gene editing J Bonafont, Á Mencía, M García, R Torres, S Rodríguez, M Carretero, ... Molecular Therapy 27 (5), 986-998, 2019 | 110 | 2019 |
| In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells M Martinez-Lage, R Torres-Ruiz, P Puig-Serra, P Moreno-Gaona, ... Nature communications 11 (1), 5060, 2020 | 106 | 2020 |
| Gain-of-function mutations in DNMT3A in patients with paraganglioma L Remacha, M Currás-Freixes, R Torres-Ruiz, F Schiavi, R Torres-Pérez, ... Genetics in Medicine 20 (12), 1644-1651, 2018 | 106 | 2018 |
| CRISPR-Cas9 technology: applications and human disease modelling Guest Editors: Lu Xiao-Jie and Ji Li-Juan, R Torres-Ruiz, ... Briefings in Functional Genomics 16 (1), 4-12, 2017 | 91 | 2017 |
| NHEJ-mediated repair of CRISPR-Cas9-induced DNA breaks efficiently corrects mutations in HSPCs from patients with fanconi anemia FJ Román-Rodríguez, L Ugalde, L Álvarez, B Díez, MJ Ramírez, ... Cell Stem Cell 25 (5), 607-621. e7, 2019 | 90 | 2019 |
| Efficient recreation of t (11; 22) EWSR1-FLI1+ in human stem cells using CRISPR/Cas9 R Torres-Ruiz, M Martinez-Lage, MC Martin, A Garcia, C Bueno, ... Stem cell reports 8 (5), 1408-1420, 2017 | 72 | 2017 |
| Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling B Oldrini, Á Curiel-García, C Marques, V Matia, Ö Uluçkan, ... Nature communications 9 (1), 1466, 2018 | 69 | 2018 |
| Targeting OGG1 arrests cancer cell proliferation by inducing replication stress T Visnes, C Benítez-Buelga, A Cázares-Körner, K Sanjiv, BMF Hanna, ... Nucleic acids research 48 (21), 12234-12251, 2020 | 55 | 2020 |
| Development refractoriness of MLL-rearranged human B cell acute leukemias to reprogramming into pluripotency A Muñoz-López, D Romero-Moya, C Prieto, V Ramos-Mejía, ... Stem cell reports 7 (4), 602-618, 2016 | 49 | 2016 |
| Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture EG Álvarez, J Demeulemeester, P Otero, C Jolly, D García-Souto, ... Nature Communications 12 (1), 6910, 2021 | 48 | 2021 |
| mTORC1 inactivation promotes colitis-induced colorectal cancer but protects from APC loss-dependent tumorigenesis M Brandt, TP Grazioso, MA Fawal, KS Tummala, R Torres-Ruiz, ... Cell Metabolism 27 (1), 118-135. e8, 2018 | 48 | 2018 |
| CRISPR-Cas9: a revolutionary tool for cancer modelling R Torres-Ruiz, S Rodriguez-Perales International Journal of Molecular Sciences 16 (9), 22151-22168, 2015 | 46 | 2015 |
| NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia B Lopez-Millan, D Sanchéz-Martínez, H Roca-Ho, F Gutiérrez-Agüera, ... Leukemia 33 (7), 1557-1569, 2019 | 43 | 2019 |
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