Formation and stability of N-heterocyclic carbenes in water: the carbon acid p K a of imidazolium cations in aqueous solution TL Amyes, ST Diver, JP Richard, FM Rivas, K Toth Journal of the American Chemical Society 126 (13), 4366-4374, 2004 | 630 | 2004 |
Mechanism for the formation of methylglyoxal from triosephosphates JP Richard Biochemical Society Transactions 21 (2), 549-553, 1993 | 342 | 1993 |
Acid-base catalysis of the elimination and isomerization reactions of triose phosphates JP Richard Journal of the American Chemical Society 106 (17), 4926-4936, 1984 | 294 | 1984 |
Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significance JP Richard Biochemistry 30 (18), 4581-4585, 1991 | 276 | 1991 |
Physical and kinetic analysis of the cooperative role of metal ions in catalysis of phosphodiester cleavage by a dinuclear Zn (II) complex O Iranzo, AY Kovalevsky, JR Morrow, JP Richard Journal of the American Chemical Society 125 (7), 1988-1993, 2003 | 273 | 2003 |
Reactions of substituted 1-phenylethyl carbocations with alcohols and other nucleophilic reagents JP Richard, WP Jencks Journal of the American Chemical Society 106 (5), 1373-1383, 1984 | 222 | 1984 |
The generation and reactions of quinone methides MM Toteva, JP Richard Advances in physical organic chemistry 45, 39-91, 2011 | 204 | 2011 |
Formation and stability of ring-substituted 1-phenylethyl carbocations JP Richard, ME Rothenberg, WP Jencks Journal of the American Chemical Society 106 (5), 1361-1372, 1984 | 199 | 1984 |
A role for flexible loops in enzyme catalysis MM Malabanan, TL Amyes, JP Richard Current opinion in structural biology 20 (6), 702-710, 2010 | 198 | 2010 |
Determination of the p K a of ethyl acetate: Brønsted correlation for deprotonation of a simple oxygen ester in aqueous solution TL Amyes, JP Richard Journal of the American Chemical Society 118 (13), 3129-3141, 1996 | 196 | 1996 |
Cooperativity between metal ions in the cleavage of phosphate diesters and RNA by dinuclear Zn (II) catalysts O Iranzo, T Elmer, JP Richard, JR Morrow Inorganic chemistry 42 (24), 7737-7746, 2003 | 182 | 2003 |
Formation and stability of carbocations and carbanions in water and intrinsic barriers to their reactions JP Richard, TL Amyes, MM Toteva Accounts of chemical research 34 (12), 981-988, 2001 | 182 | 2001 |
A simple relationship between carbocation lifetime and reactivity-selectivity relationships for the solvolysis of ring-substituted 1-phenylethyl derivatives JP Richard, WP Jencks Journal of the American Chemical Society 104 (17), 4689-4691, 1982 | 169 | 1982 |
Experimental and computational determination of the effect of the cyano group on carbon acidity in water JP Richard, G Williams, J Gao Journal of the American Chemical Society 121 (4), 715-726, 1999 | 162 | 1999 |
Generation and stability of a simple thiol ester enolate in aqueous solution TL Amyes, JP Richard Journal of the American Chemical Society 114 (26), 10297-10302, 1992 | 156 | 1992 |
Concerted bimolecular substitution reactions of 1-phenylethyl derivatives JP Richard, WP Jencks Journal of the American Chemical Society 106 (5), 1383-1396, 1984 | 150 | 1984 |
Formation and stability of organic zwitterions in aqueous solution: enolates of the amino acid glycine and its derivatives A Rios, TL Amyes, JP Richard Journal of the American Chemical Society 122 (39), 9373-9385, 2000 | 134 | 2000 |
Mechanistic imperatives for aldose− ketose isomerization in water: specific, general base-and metal ion-catalyzed isomerization of glyceraldehyde with proton and hydride transfer RW Nagorski, JP Richard Journal of the American Chemical Society 123 (5), 794-802, 2001 | 133 | 2001 |
Protein flexibility and stiffness enable efficient enzymatic catalysis JP Richard Journal of the American Chemical Society 141 (8), 3320-3331, 2019 | 127 | 2019 |
Proton transfer at carbon JP Richard, TL Amyes Current opinion in chemical biology 5 (6), 626-633, 2001 | 126 | 2001 |