| Triggered Drug Release from an Antibody-Drug Conjugate using Fast “Click-to-Release” Chemistry in Mice R Rossin, SMJ van Duijnhoven, W ten Hoeve, HM Janssen, LHJ Kleijn, ... Bioconjugate Chemistry 27 (7), 1697–1706, 2016 | 244 | 2016 |
| Semisynthetic lipopeptides derived from nisin display antibacterial activity and lipid II binding on par with that of the parent compound T Koopmans, TM Wood, P ’t Hart, LHJ Kleijn, APA Hendrickx, RJL Willems, ... Journal of the american chemical society 137 (29), 9382-9389, 2015 | 79 | 2015 |
| Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action LHJ Kleijn, SF Oppedijk, P ’t Hart, RM van Harten, LA Martin-Visscher, ... Journal of Medicinal Chemistry 59 (7), 3569-3574, 2016 | 42 | 2016 |
| A combined solid-and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics P 't Hart*, LHJ Kleijn*, G de Bruin, SF Oppedijk, J Kemmink, NI Martin Organic & Biomolecular Chemistry 12 (6), 913-918, 2014 | 38 | 2014 |
| High‐resolution crystal structure reveals molecular details of target recognition by the calcium‐dependent lipopeptide antibiotic laspartomycin C LHJ Kleijn*, HC Vlieg*, TM Wood, J Sastre Toraño, BJC Janssen, ... Angewandte Chemie 129 (52), 16773-16776, 2017 | 34 | 2017 |
| A concise preparation of the non-proteinogenic amino acid L-kynurenine LHJ Kleijn, FM Müskens, SF Oppedijk, G de Bruin, NI Martin Tetrahedron Letters 53 (47), 6430-6432, 2012 | 21 | 2012 |
| Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology H Bolt*, L Kleijn*, N Martin, S Cobb Molecules 23 (7), 1566, 2018 | 19 | 2018 |
| The Cyclic Lipopeptide Antibiotics LHJ Kleijn, NI Martin Topics in Medicinal Chemistry, Springer, 1-27, 2017 | 16 | 2017 |
| A Concise Synthetic Approach to Highly Reactive Click‐to‐Release Trans‐Cyclooctene Linkers** B Liu, W Ten Hoeve, RM Versteegen, R Rossin, LHJ Kleijn, MS Robillard Chemistry–A European Journal 29 (45), e202300755, 2023 | 12 | 2023 |
| Click-to-release: cleavable radioimmunoimaging with [89Zr] Zr-DFO-trans-cyclooctene-trastuzumab increases tumor-to-blood ratio M Vlastara, R Rossin, FJM Hoeben, KE de Roode, M Boswinkel, ... Theranostics 13 (12), 4004, 2023 | 11 | 2023 |
| Methods for preparing cyclooctenes andconjugates thereof W Ten Hoeve, MS Robillard, C Ferrer, LHJ Kleijn, RM Versteegen US Patent App. 18/282,331, 2024 | | 2024 |
| Masked IL12 protein MHMGM DEN, MS Robillard, R Rossin, LHJ KLEIJN, KE DE ROODE, ... | | 2023 |
| Agents for cleaving labels from biomolecules in vivo R Rossin, MS Robillard, LHJ Kleijn US Patent App. 17/619,796, 2022 | | 2022 |
| Nisin-based compounds and use thereof in the treatment of bacterial infections NI Martin, T Koopmans, TM Wood, LHJ Kleijn US Patent App. 15/543,660, 2017 | | 2017 |