Các bài viết có thể truy cập công khai - Aubry K. MillerTìm hiểu thêm
Không có ở bất kỳ nơi nào: 5
Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development
J Lohbeck, AK Miller
Bioorganic & Medicinal Chemistry Letters 26 (21), 5260-5262, 2016
Các cơ quan ủy nhiệm: Helmholtz Association
Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity
X Chen, X Chen, RR Steimbach, T Wu, H Li, W Dan, P Shi, C Cao, D Li, ...
European Journal of Medicinal Chemistry 187, 111950, 2020
Các cơ quan ủy nhiệm: US National Institutes of Health, National Natural Science Foundation of China
Spiroepoxytriazoles are fumagillin-like irreversible inhibitors of MetAP2 with potent cellular activity
M Morgen, C Jöst, M Malz, R Janowski, D Niessing, CD Klein, N Gunkel, ...
ACS Chemical Biology 11 (4), 1001-1011, 2016
Các cơ quan ủy nhiệm: US National Institutes of Health, Helmholtz Association
Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity
E De Vita, P Schüler, S Lovell, J Lohbeck, S Kullmann, E Rabinovich, ...
Journal of medicinal chemistry 61 (19), 8859-8874, 2018
Các cơ quan ủy nhiệm: US National Institutes of Health, European Molecular Biology Laboratory …
Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
X Chen, J Wang, P Zhao, B Dang, T Liang, RR Steimbach, AK Miller, J Liu, ...
European Journal of Medicinal Chemistry 260, 115776, 2023
Các cơ quan ủy nhiệm: National Natural Science Foundation of China
Có tại một số nơi: 33
Regulation of mitochondrial morphology and function by stearoylation of TFR1
D Senyilmaz, S Virtue, X Xu, CY Tan, JL Griffin, AK Miller, A Vidal-Puig, ...
Nature 525 (7567), 124-128, 2015
Các cơ quan ủy nhiệm: German Research Foundation, UK Biotechnology and Biological Sciences …
Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of type 2 diabetes
A Moraru, J Wiederstein, D Pfaff, T Fleming, AK Miller, P Nawroth, ...
Cell metabolism 27 (4), 926-934. e8, 2018
Các cơ quan ủy nhiệm: German Research Foundation, Helmholtz Association
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals
U Barayeu, D Schilling, M Eid, TN Xavier da Silva, L Schlicker, N Mitreska, ...
Nature chemical biology 19 (1), 28-37, 2023
Các cơ quan ủy nhiệm: German Research Foundation, European Commission
Selective inhibition of histone deacetylase 10: hydrogen bonding to the gatekeeper residue is implicated
M Géraldy, M Morgen, P Sehr, RR Steimbach, D Moi, J Ridinger, I Oehme, ...
Journal of medicinal Chemistry 62 (9), 4426-4443, 2019
Các cơ quan ủy nhiệm: US National Institutes of Health, Helmholtz Association, Federal Ministry of …
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target
S Lechner, MIP Malgapo, C Grätz, RR Steimbach, A Baron, P Rüther, ...
Nature chemical biology 18 (8), 812-820, 2022
Các cơ quan ủy nhiệm: US National Institutes of Health, German Research Foundation, Helmholtz …
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
J Ridinger, E Koeneke, FR Kolbinger, K Koerholz, S Mahboobi, L Hellweg, ...
Scientific reports 8 (1), 10039, 2018
Các cơ quan ủy nhiệm: Helmholtz Association
The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines
FR Kolbinger, E Koeneke, J Ridinger, T Heimburg, M Müller, T Bayer, ...
Archives of toxicology 92, 2649-2664, 2018
Các cơ quan ủy nhiệm: German Research Foundation
Commonly used alkylating agents limit persulfide detection by converting protein persulfides into thioethers
D Schilling, U Barayeu, RR Steimbach, D Talwar, AK Miller, TP Dick
Angewandte Chemie 134 (30), e202203684, 2022
Các cơ quan ủy nhiệm: German Research Foundation
Structural basis for the selective inhibition of HDAC10, the cytosolic polyamine deacetylase
CJ Herbst-Gervasoni, RR Steimbach, M Morgen, AK Miller, ...
ACS chemical biology 15 (8), 2154-2163, 2020
Các cơ quan ủy nhiệm: US Department of Energy, US National Institutes of Health, European …
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering
A Sananes, I Cohen, A Shahar, A Hockla, E De Vita, AK Miller, ...
Journal of Biological Chemistry 293 (33), 12663-12680, 2018
Các cơ quan ủy nhiệm: US National Science Foundation, US National Institutes of Health, Helmholtz …
Design and synthesis of dihydroxamic acids as HDAC6/8/10 inhibitors
M Morgen, RR Steimbach, M Géraldy, L Hellweg, P Sehr, J Ridinger, ...
ChemMedChem 15 (13), 1163-1174, 2020
Các cơ quan ủy nhiệm: US Department of Energy, US National Institutes of Health, Helmholtz …
Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins
H Nůsková, MV Serebryakova, A Ferrer-Caelles, T Sachsenheimer, ...
Nature communications 12 (1), 4590, 2021
Các cơ quan ủy nhiệm: German Research Foundation, European Commission
Aza-SAHA derivatives are selective histone deacetylase 10 chemical probes that inhibit polyamine deacetylation and phenocopy HDAC10 knockout
RR Steimbach, CJ Herbst-Gervasoni, S Lechner, TM Stewart, G Klinke, ...
Journal of the American Chemical Society 144 (41), 18861-18875, 2022
Các cơ quan ủy nhiệm: US Department of Energy, US National Institutes of Health, German Research …
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
E De Vita, N Smits, H van den Hurk, EM Beck, J Hewitt, G Baillie, ...
ChemMedChem 15 (1), 79-95, 2020
Các cơ quan ủy nhiệm: US National Institutes of Health
Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid
S Lechner, RR Steimbach, L Wang, ML Deline, YC Chang, T Fromme, ...
Nature Communications 14 (1), 3548, 2023
Các cơ quan ủy nhiệm: German Research Foundation, European Commission
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