| Targeting the BIR domains of inhibitor of apoptosis (IAP) proteins in cancer treatment F Cossu, M Milani, E Mastrangelo, D Lecis Computational and Structural Biotechnology Journal 17, 142-150, 2019 | 101 | 2019 |
| TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy JC DiFrancesco, F Novara, O Zuffardi, A Forlino, R Gioia, F Cossu, ... Neurological sciences 36, 323-330, 2015 | 78 | 2015 |
| Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2 F Cossu, E Mastrangelo, M Milani, G Sorrentino, D Lecis, D Delia, ... Biochemical and biophysical research communications 378 (2), 162-167, 2009 | 73 | 2009 |
| Structural basis for bivalent Smac-mimetics recognition in the IAP protein family F Cossu, M Milani, E Mastrangelo, P Vachette, F Servida, D Lecis, ... Journal of molecular biology 392 (3), 630-644, 2009 | 54 | 2009 |
| Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo [5.3. 0] alkane smac mimetics. Structure, activity, and recognition principles E Mastrangelo, F Cossu, M Milani, G Sorrentino, D Lecis, D Delia, ... Journal of molecular biology 384 (3), 673-689, 2008 | 49 | 2008 |
| Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization D Lecis, E Mastrangelo, L Belvisi, M Bolognesi, M Civera, F Cossu, ... Bioorganic & medicinal chemistry 20 (22), 6709-6723, 2012 | 38 | 2012 |
| Kinetic and structural evidences on human prolidase pathological mutants suggest strategies for enzyme functional rescue R Besio, R Gioia, F Cossu, E Monzani, S Nicolis, L Cucca, A Profumo, ... PloS one 8 (3), e58792, 2013 | 30 | 2013 |
| Recognition of Smac‐mimetic compounds by the BIR domain of cIAP1 F Cossu, F Malvezzi, G Canevari, E Mastrangelo, D Lecis, D Delia, ... Protein science 19 (12), 2418-2429, 2010 | 29 | 2010 |
| The activator of apoptosis Smac-DIABLO acts as a tetramer in solution E Mastrangelo, P Vachette, F Cossu, F Malvezzi, M Bolognesi, M Milani Biophysical Journal 108 (3), 714-723, 2015 | 25 | 2015 |
| Structural insight into inhibitor of apoptosis proteins recognition by a potent divalent smac-mimetic F Cossu, M Milani, P Vachette, F Malvezzi, S Grassi, D Lecis, D Delia, ... PLoS One 7 (11), e49527, 2012 | 23 | 2012 |
| Cellulose production is coupled to sensing of the pyrimidine biosynthetic pathway via c‐di‐GMP production by the DgcQ protein of Escherichia coli E Rossi, S Motta, A Aliverti, F Cossu, L Gourlay, P Mauri, P Landini Environmental Microbiology 19 (11), 4551-4563, 2017 | 21 | 2017 |
| Homo-and heterodimeric SMAC mimetic compounds as apoptosis inducers P Seneci, L Belvisi, F Cossu, D Delia, C Drago, D Lecis, S Maiorana, ... US Patent 9,321,808, 2016 | 20 | 2016 |
| Structure‐based design and molecular profiling of Smac‐mimetics selective for cellular IAP s A Corti, M Milani, D Lecis, P Seneci, M de Rosa, E Mastrangelo, F Cossu The FEBS journal 285 (17), 3286-3298, 2018 | 16 | 2018 |
| Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor L Sorrentino, F Cossu, M Milani, A Aliverti, E Mastrangelo Biochemical and Biophysical Research Communications 490 (3), 1011-1017, 2017 | 14 | 2017 |
| Novel neurofibromatosis type 2 mutation presenting with status epilepticus JC DiFrancesco, R Sestini, F Cossu, M Bolognesi, E Sala, S Mariani, ... Epileptic Disorders 16 (1), 132-137, 2014 | 13 | 2014 |
| NF023 binding to XIAP‐BIR1: Searching drugs for regulation of the NF‐κB pathway F Cossu, M Milani, S Grassi, F Malvezzi, A Corti, M Bolognesi, ... Proteins: Structure, Function, and Bioinformatics 83 (4), 612-620, 2015 | 11 | 2015 |
| A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein D Potenza, L Belvisi, F Vasile, E Moroni, F Cossu, P Seneci Organic & biomolecular chemistry 10 (16), 3278-3287, 2012 | 10 | 2012 |
| Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway F Cossu, S Camelliti, D Lecis, L Sorrentino, MT Majorini, M Milani, ... Computational and Structural Biotechnology Journal 19, 6366-6374, 2021 | 8 | 2021 |
| Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1 L Sorrentino, F Cossu, M Milani, B Malkoc, WC Huang, SC Tsay, ... ChemistryOpen 8 (4), 476-482, 2019 | 7 | 2019 |
| CHCHD4 binding affects the active site of apoptosis inducing factor (AIF): Structural determinants for allosteric regulation E Fagnani, P Cocomazzi, S Pellegrino, G Tedeschi, FG Scalvini, F Cossu, ... Structure 32 (5), 594-602. e4, 2024 | 3 | 2024 |
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