| ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ... Nature medicine 19 (2), 202-208, 2013 | 3310 | 2013 |
| Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function L Chen, SN Willis, A Wei, BJ Smith, JI Fletcher, MG Hinds, PM Colman, ... Molecular cell 17 (3), 393-403, 2005 | 2303 | 2005 |
| The Bcl-2 family: roles in cell survival and oncogenesis S Cory, D Huang, JM Adams Oncogene 22 (53), 8590-8607, 2003 | 2132 | 2003 |
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity P Bouillet, D Metcalf, DCS Huang, DM Tarlinton, TWH Kay, F Kontgen, ... Science 286 (5445), 1735-1738, 1999 | 1917 | 1999 |
| Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins SN Willis, L Chen, G Dewson, A Wei, E Naik, JI Fletcher, JM Adams, ... Genes & development 19 (11), 1294-1305, 2005 | 1629 | 2005 |
| Bim: a novel member of the Bcl‐2 family that promotes apoptosis L O'Connor, A Strasser, LA O'Reilly, G Hausmann, JM Adams, S Cory, ... The EMBO journal, 1998 | 1498 | 1998 |
| The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized MF Van Delft, AH Wei, KD Mason, CJ Vandenberg, L Chen, PE Czabotar, ... Cancer cell 10 (5), 389-399, 2006 | 1490 | 2006 |
| The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex H Puthalakath, DCS Huang, LA O’Reilly, SM King, A Strasser Molecular cell 3 (3), 287-296, 1999 | 1487 | 1999 |
| Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak SN Willis, JI Fletcher, T Kaufmann, MF van Delft, L Chen, PE Czabotar, ... Science 315 (5813), 856-859, 2007 | 1478 | 2007 |
| BH3-only proteins—essential initiators of apoptotic cell death DCS Huang, A Strasser Cell 103 (6), 839-842, 2000 | 1425 | 2000 |
| Programmed anuclear cell death delimits platelet life span KD Mason, MR Carpinelli, JI Fletcher, JE Collinge, AA Hilton, S Ellis, ... Cell 128 (6), 1173-1186, 2007 | 1252 | 2007 |
| The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models A Kotschy, Z Szlavik, J Murray, J Davidson, AL Maragno, ... Nature 538 (7626), 477-482, 2016 | 1099 | 2016 |
| Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease AW Roberts, JF Seymour, JR Brown, WG Wierda, TJ Kipps, SL Khaw, ... Journal of Clinical Oncology 30 (5), 488-496, 2012 | 978 | 2012 |
| Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis. A Strasser, AW Harris, DC Huang, PH Krammer, S Cory The EMBO journal 14 (24), 6136-6147, 1995 | 939 | 1995 |
| Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production MJ White, K McArthur, D Metcalf, RM Lane, JC Cambier, MJ Herold, ... Cell 159 (7), 1549-1562, 2014 | 921 | 2014 |
| Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 IE Wertz, S Kusam, C Lam, T Okamoto, W Sandoval, DJ Anderson, ... Nature 471 (7336), 110-114, 2011 | 916 | 2011 |
| Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis H Puthalakath, A Villunger, LA O'Reilly, JG Beaumont, L Coultas, ... Science 293 (5536), 1829-1832, 2001 | 838 | 2001 |
| Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival M Schwickart, XD Huang, JR Lill, J Liu, R Ferrando, DM French, ... Nature 463 (7277), 103-107, 2010 | 754 | 2010 |
| Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome VS Marsden, L O'Connor, LA O'Reilly, J Silke, D Metcalf, PG Ekert, ... Nature 419 (6907), 634-637, 2002 | 730 | 2002 |
| Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ... Cell 152 (3), 519-531, 2013 | 672 | 2013 |
Andreas StrasserThe Walter and Eliza Hall InstituteEmail được xác minh tại wehi.edu.au