Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist FS Willard, JD Douros, MBN Gabe, AD Showalter, DB Wainscott, ... JCI insight 5 (17), e140532, 2020 | 317 | 2020 |
β Cell tone is defined by proglucagon peptides through cAMP signaling ME Capozzi, B Svendsen, SE Encisco, SL Lewandowski, MD Martin, ... JCI insight 4 (5), e126742, 2019 | 239 | 2019 |
Glucagon lowers glycemia when β cells are active ME Capozzi, JB Wait, J Koech, AN Gordon, RW Coch, B Svendsen, ... JCI insight 4 (16), e129954, 2019 | 159 | 2019 |
Pyruvate kinase controls signal strength in the insulin secretory pathway SL Lewandowski, RL Cardone, HR Foster, T Ho, E Potapenko, C Poudel, ... Cell metabolism 32 (5), 736-750. e5, 2020 | 137 | 2020 |
Targeting the incretin/glucagon system with triagonists to treat diabetes ME Capozzi, RD DiMarchi, MH Tschöp, B Finan, JE Campbell Endocrine reviews 39 (5), 719-738, 2018 | 133 | 2018 |
GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells K El, SM Gray, ME Capozzi, ER Knuth, E Jin, B Svendsen, A Clifford, ... Science advances 7 (11), eabf1948, 2021 | 114 | 2021 |
Repositioning glucagon action in the physiology and pharmacology of diabetes B Finan, ME Capozzi, JE Campbell Diabetes 69 (4), 532-541, 2020 | 106 | 2020 |
Inactivation of the glucose-dependent insulinotropic polypeptide receptor improves outcomes following experimental myocardial infarction JR Ussher, JE Campbell, EE Mulvihill, LL Baggio, HE Bates, BA McLean, ... Cell metabolism 27 (2), 450-460. e6, 2018 | 81 | 2018 |
The limited role of glucagon for ketogenesis during fasting or in response to SGLT2 inhibition ME Capozzi, RW Coch, J Koech, II Astapova, JB Wait, SE Encisco, ... Diabetes 69 (5), 882-892, 2020 | 59 | 2020 |
The past, present, and future physiology and pharmacology of glucagon ME Capozzi, DA D’Alessio, JE Campbell Cell metabolism 34 (11), 1654-1674, 2022 | 58 | 2022 |
Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia CA Gilroy, ME Capozzi, AK Varanko, J Tong, DA D'alessio, JE Campbell, ... Science advances 6 (35), eaaz9890, 2020 | 58 | 2020 |
Pimozide alleviates hyperglycemia in diet-induced obesity by inhibiting skeletal muscle ketone oxidation R Al Batran, K Gopal, ME Capozzi, JJ Chahade, B Saleme, ... Cell metabolism 31 (5), 909-919. e8, 2020 | 57 | 2020 |
Pharmacological antagonism of the incretin system protects against diet-induced obesity B Svendsen, ME Capozzi, J Nui, SA Hannou, B Finan, J Naylor, P Ravn, ... Molecular metabolism 32, 44-55, 2020 | 53 | 2020 |
Circadian perinatal photoperiod has enduring effects on retinal dopamine and visual function CR Jackson, M Capozzi, H Dai, DG McMahon Journal of Neuroscience 34 (13), 4627-4633, 2014 | 52 | 2014 |
Epoxygenated fatty acids inhibit retinal vascular inflammation ME Capozzi, SS Hammer, GW McCollum, JS Penn Scientific reports 6 (1), 39211, 2016 | 49 | 2016 |
Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ S Suarez, GW McCollum, CA Bretz, R Yang, ME Capozzi, JS Penn Investigative ophthalmology & visual science 55 (12), 8232-8240, 2014 | 49 | 2014 |
Molecular probes for imaging of hypoxia in the retina SM Evans, K Kim, CE Moore, MI Uddin, ME Capozzi, JR Craft, ... Bioconjugate chemistry 25 (11), 2030-2037, 2014 | 46 | 2014 |
The role of cytochrome P450 epoxygenases in retinal angiogenesis ME Capozzi, GW McCollum, JS Penn Investigative ophthalmology & visual science 55 (7), 4253-4260, 2014 | 45 | 2014 |
Enhanced glucose control following vertical sleeve gastrectomy does not require a β-cell glucagon-like peptide 1 receptor JD Douros, AG Lewis, EP Smith, JJ Niu, M Capozzi, A Wittmann, ... Diabetes 67 (8), 1504-1511, 2018 | 38 | 2018 |
Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types WM Watkins, GW McCollum, SR Savage, ME Capozzi, JS Penn, ... Experimental eye research 116, 240-246, 2013 | 36 | 2013 |