| Automated design of ligands to polypharmacological profiles J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ... Nature 492 (7428), 215-220, 2012 | 897 | 2012 |
| Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 894 | 2021 |
| Lessons learnt from assembling screening libraries for drug discovery for neglected diseases R Brenk, A Schipani, D James, A Krasowski, IH Gilbert, J Frearson, ... ChemMedChem: Chemistry Enabling Drug Discovery 3 (3), 435-444, 2008 | 660 | 2008 |
| A novel multiple-stage antimalarial agent that inhibits protein synthesis B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ... Nature 522 (7556), 315-320, 2015 | 488 | 2015 |
| Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ... Nature Reviews Microbiology 15 (4), 217-231, 2017 | 441 | 2017 |
| N-myristoyltransferase inhibitors as new leads to treat sleeping sickness JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ... Nature 464 (7289), 728-732, 2010 | 330 | 2010 |
| Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites A Baliani, GJ Bueno, ML Stewart, V Yardley, R Brun, MP Barrett, IH Gilbert Journal of medicinal chemistry 48 (17), 5570-5579, 2005 | 243 | 2005 |
| Drug discovery for neglected diseases: molecular target-based and phenotypic approaches: miniperspectives series on phenotypic screening for antiinfective targets IH Gilbert Journal of medicinal chemistry 56 (20), 7719-7726, 2013 | 230 | 2013 |
| Challenges and recent progress in drug discovery for tropical diseases M De Rycker, B Baragaña, SL Duce, IH Gilbert Nature 559 (7715), 498-506, 2018 | 218 | 2018 |
| Fragment-based hit identification: thinking in 3D AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ... Drug Discovery Today 18 (23-24), 1221-1227, 2013 | 192 | 2013 |
| Target assessment for antiparasitic drug discovery JA Frearson, PG Wyatt, IH Gilbert, AH Fairlamb Trends in parasitology 23 (12), 589-595, 2007 | 186 | 2007 |
| Synthesis and Biological Evaluation of s-Triazine Substituted Polyamines as Potential New Anti-Trypanosomal Drugs B Klenke, M Stewart, MP Barrett, R Brun, IH Gilbert Journal of Medicinal Chemistry 44 (21), 3440-3452, 2001 | 175 | 2001 |
| Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay M De Rycker, I Hallyburton, J Thomas, L Campbell, S Wyllie, D Joshi, ... Antimicrobial agents and chemotherapy 57 (7), 2913-2922, 2013 | 168 | 2013 |
| Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes IH Gilbert Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002 | 166 | 2002 |
| Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition S Wyllie, S Brand, M Thomas, M De Rycker, C Chung, I Pena, ... Proceedings of the National Academy of Sciences 116 (19), 9318-9323, 2019 | 161 | 2019 |
| Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein … S Patterson, MS Alphey, DC Jones, EJ Shanks, IP Street, JA Frearson, ... Journal of medicinal chemistry 54 (19), 6514-6530, 2011 | 154 | 2011 |
| Target validation: linking target and chemical properties to desired product profile P G Wyatt, I H Gilbert, K D Read, A H Fairlamb Current topics in medicinal chemistry 11 (10), 1275-1283, 2011 | 147 | 2011 |
| Characterising covalent warhead reactivity JS Martin, CJ MacKenzie, D Fletcher, IH Gilbert Bioorganic & medicinal chemistry 27 (10), 2066-2074, 2019 | 140 | 2019 |
| Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells H Rudyk, S Vasiljevic, RM Hennion, CR Birkett, J Hope, IH Gilbert Journal of General Virology 81 (4), 1155-1164, 2000 | 140 | 2000 |
| Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis S Wyllie, M Thomas, S Patterson, S Crouch, M De Rycker, R Lowe, ... Nature 560 (7717), 192-197, 2018 | 136 | 2018 |
