| Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling JE Longbotham, CM Chio, V Dharmarajan, MJ Trnka, IO Torres, ... Nature communications 10 (1), 94, 2019 | 48 | 2019 |
| Convergence of theory and experiment on the role of preorganization, quantum tunneling, and enzyme motions into flavoenzyme-catalyzed hydride transfer M Delgado, S Gorlich, JE Longbotham, NS Scrutton, S Hay, V Moliner, ... ACS catalysis 7 (5), 3190-3198, 2017 | 43 | 2017 |
| Untangling heavy protein and cofactor isotope effects on enzyme-catalyzed hydride transfer JE Longbotham, SJO Hardman, S Gorlich, NS Scrutton, S Hay Journal of the American Chemical Society 138 (41), 13693-13699, 2016 | 36 | 2016 |
| Structure and mechanism of a viral collagen prolyl hydroxylase JE Longbotham, C Levy, LO Johannissen, H Tarhonskaya, S Jiang, ... Biochemistry 54 (39), 6093-6105, 2015 | 30 | 2015 |
| Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2 IP Chen, JE Longbotham, S McMahon, RK Suryawanshi, MM Khalid, ... Cell Reports 40 (3), 2022 | 24 | 2022 |
| Extended recognition of the histone H3 tail by histone demethylase KDM5A N Petronikolou, JE Longbotham, DG Fujimori Biochemistry 59 (5), 647-651, 2020 | 22 | 2020 |
| Recognition of histone H3 methylation states by the PHD1 domain of histone demethylase KDM5A JE Longbotham, MJS Kelly, DG Fujimori ACS Chemical Biology, 2021 | 14 | 2021 |
| Domain cross-talk in regulation of histone modifications: molecular mechanisms and targeting opportunities JE Longbotham, MY Zhang, DG Fujimori Current opinion in chemical biology 57, 105-113, 2020 | 11 | 2020 |
| Exploring the ligand preferences of the PHD1 domain of histone demethylase KDM5A reveals tolerance for modifications of the Q5 residue of histone 3 SE Anderson, JE Longbotham, PT O’Kane, FS Ugur, DG Fujimori, ... ACS chemical biology 16 (1), 205-213, 2020 | 6 | 2020 |
| Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening G Ortiz, JE Longbotham, SL Qin, MY Zhang, GM Lee, RJ Neitz, MJS Kelly, ... RSC Chemical Biology 5 (3), 209-215, 2024 | 1 | 2024 |
| Dissecting contributions of catalytic and reader domains in regulation of histone demethylation N Petronikolou, JE Longbotham, DG Fujimori Methods in enzymology 639, 217-236, 2020 | 1 | 2020 |