| The Caco-2 cell monolayer: usefulness and limitations H Sun, ECY Chow, S Liu, Y Du, KS Pang Expert opinion on drug metabolism & toxicology 4 (4), 395-411, 2008 | 608 | 2008 |
| β-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation Y Chen, HC Whetstone, A Youn, P Nadesan, ECY Chow, AC Lin, ... Journal of Biological Chemistry 282 (1), 526-533, 2007 | 277 | 2007 |
| 1α, 25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease MR Durk, K Han, ECY Chow, R Ahrens, JT Henderson, PE Fraser, ... Journal of Neuroscience 34 (21), 7091-7101, 2014 | 189 | 2014 |
| 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration H Wang, PC Brown, ECY Chow, L Ewart, SS Ferguson, S Fitzpatrick, ... Clinical and translational science 14 (5), 1659-1680, 2021 | 153 | 2021 |
| FDA approval summary: fam-trastuzumab deruxtecan-nxki for the treatment of unresectable or metastatic HER2-positive breast cancer P Narayan, CL Osgood, H Singh, HJ Chiu, TK Ricks, E Chiu Yuen Chow, ... Clinical cancer research 27 (16), 4478-4485, 2021 | 141 | 2021 |
| Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol ECY Chow, L Magomedova, HP Quach, R Patel, MR Durk, J Fan, ... Gastroenterology 146 (4), 1048-1059. e7, 2014 | 107 | 2014 |
| Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver AA Khan, ECY Chow, AMA van Loenen-Weemaes, RJ Porte, KS Pang, ... European Journal of Pharmaceutical Sciences 37 (2), 115-125, 2009 | 103 | 2009 |
| 1α,25‐Dihydroxyvitamin D3‐liganded vitamin D receptor increases expression and transport activity of P‐glycoprotein in isolated rat brain capillaries and human … MR Durk, GNY Chan, CR Campos, JC Peart, ECY Chow, E Lee, ... Journal of neurochemistry 123 (6), 944-953, 2012 | 99 | 2012 |
| 1α, 25-Dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr (−/−) and fxr (+/+) mice and increased renal and … ECY Chow, MR Durk, CL Cummins, KS Pang The Journal of pharmacology and experimental therapeutics 337 (3), 846-859, 2011 | 97 | 2011 |
| 1α,25‐dihydroxyvitamin D3 triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo ECY Chow, HJ Maeng, S Liu, AA Khan, GMM Groothuis, KS Pang Biopharmaceutics & drug disposition 30 (8), 457-475, 2009 | 88 | 2009 |
| Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice ECY Chow, HP Quach, R Vieth, KS Pang American Journal of Physiology-Endocrinology and Metabolism 304 (9), E977-E989, 2013 | 82 | 2013 |
| Effects of 1α,25‐dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo ECY Chow, H Sun, AA Khan, GMM Groothuis, KS Pang Biopharmaceutics & drug disposition 31 (1), 91-108, 2010 | 79 | 2010 |
| Investigating the impact of drug crystallinity in amorphous tacrolimus capsules on pharmacokinetics and bioequivalence using discriminatory in vitro dissolution testing and … HS Purohit, NS Trasi, DD Sun, ECY Chow, H Wen, X Zhang, Y Gao, ... Journal of pharmaceutical sciences 107 (5), 1330-1341, 2018 | 75 | 2018 |
| PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism J Fan, S Chen, E CY Chow, K Sandy Pang Current drug metabolism 11 (9), 743-761, 2010 | 70 | 2010 |
| Expression and regulation of the bile acid transporter, OSTα‐OSTβ in rat and human intestine and liver AA Khan, ECY Chow, RJ Porte, KS Pang, GMM Groothuis Biopharmaceutics & drug disposition 30 (5), 241-258, 2009 | 56 | 2009 |
| FDA approval summary: ivosidenib for the treatment of patients with advanced unresectable or metastatic, chemotherapy refractory cholangiocarcinoma with an IDH1 mutation SJ Casak, S Pradhan, LA Fashoyin-Aje, Y Ren, YL Shen, Y Xu, ... Clinical cancer research 28 (13), 2733-2737, 2022 | 52 | 2022 |
| Why we need proper PBPK models to examine intestine and liver oral drug absorption E CY Chow, K Sandy Pang Current drug metabolism 14 (1), 57-79, 2013 | 49 | 2013 |
| The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices AA Khan, ECY Chow, RJ Porte, KS Pang, GMM Groothuis Toxicology in Vitro 25 (1), 80-90, 2011 | 40 | 2011 |
| Using physiologically based pharmacokinetic (PBPK) modeling to evaluate the impact of pharmaceutical excipients on oral drug absorption: sensitivity analyses ECY Chow, A Talattof, E Tsakalozou, J Fan, L Zhao, X Zhang The AAPS journal 18, 1500-1511, 2016 | 39 | 2016 |
| A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition H Sun, L Zhang, ECY Chow, G Lin, Z Zuo, KS Pang The Journal of pharmacology and experimental therapeutics 326 (1), 117-126, 2008 | 39 | 2008 |