| Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair P Strop, WH Ho, LM Boustany, YN Abdiche, KC Lindquist, SE Farias, ... Journal of molecular biology 420 (3), 204-219, 2012 | 257 | 2012 |
| Increasing serum half-life and extending cholesterol lowering in vivo by engineering antibody with pH-sensitive binding to PCSK9 J Chaparro-Riggers, H Liang, RM DeVay, L Bai, JE Sutton, W Chen, ... Journal of Biological Chemistry 287 (14), 11090-11097, 2012 | 226 | 2012 |
| Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users PS Katsamba, I Navratilova, M Calderon-Cacia, L Fan, K Thornton, M Zhu, ... Analytical biochemistry 352 (2), 208-221, 2006 | 211 | 2006 |
| The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity YN Abdiche, YA Yeung, J Chaparro-Riggers, I Barman, P Strop, SM Chin, ... MAbs 7 (2), 331-343, 2015 | 184 | 2015 |
| Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading P Strop, K Delaria, D Foletti, JM Witt, A Hasa-Moreno, K Poulsen, ... Nature biotechnology 33 (7), 694-696, 2015 | 165 | 2015 |
| Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab SM Chin, CR Kimberlin, Z Roe-Zurz, P Zhang, A Xu, S Liao-Chan, D Sen, ... Nature communications 9 (1), 1-13, 2018 | 141 | 2018 |
| A global benchmark study using affinity-based biosensors RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ... Analytical biochemistry 386 (2), 194-216, 2009 | 131 | 2009 |
| High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region MJ Osborn, B Ma, S Avis, A Binnie, J Dilley, X Yang, K Lindquist, ... The Journal of Immunology 190 (4), 1481-1490, 2013 | 127 | 2013 |
| Synthetic antibodies designed on natural sequence landscapes W Zhai, J Glanville, M Fuhrmann, L Mei, I Ni, PD Sundar, T Van Blarcom, ... Journal of molecular biology 412 (1), 55-71, 2011 | 105 | 2011 |
| Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity SH Chen, PK Dominik, J Stanfield, S Ding, W Yang, N Kurd, R Llewellyn, ... Journal for immunotherapy of cancer 9 (10), 2021 | 104 | 2021 |
| Affinity and kinetics of sialyl Lewis-X and core-2 based oligosaccharides binding to L-and P-selectin ME Beauharnois, KC Lindquist, D Marathe, P Vanderslice, J Xia, KL Matta, ... Biochemistry 44 (27), 9507-9519, 2005 | 94 | 2005 |
| Targeting CLDN18. 2 by CD3 bispecific and ADC modalities for the treatments of gastric and pancreatic cancer G Zhu, D Foletti, X Liu, S Ding, JM Witt, A Hasa-Moreno, M Rickert, C Holz, ... Scientific reports 9 (1), 1-11, 2019 | 65 | 2019 |
| Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia MK Kashyap, CI Amaya-Chanaga, D Kumar, B Simmons, N Huser, Y Gu, ... Journal of hematology & oncology 10 (1), 1-16, 2017 | 60 | 2017 |
| An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity Y Xu, LC Carrascosa, YA Yeung, MLH Chu, W Yang, I Djuretic, ... Cancer Immunology Research, 2021 | 52 | 2021 |
| A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies SH Liu, Y Gu, B Pascual, Z Yan, M Hallin, C Zhang, C Fan, W Wang, ... Blood advances 1 (15), 1088-1100, 2017 | 50 | 2017 |
| Expanding the ProteOn XPR36 biosensor into a 36-ligand array expedites protein interaction analysis YN Abdiche, KC Lindquist, A Pinkerton, J Pons, A Rajpal Analytical biochemistry 411 (1), 139-151, 2011 | 47 | 2011 |
| Exploring the dynamic range of the kinetic exclusion assay in characterizing antigen-antibody interactions C Bee, YN Abdiche, DM Stone, S Collier, KC Lindquist, AC Pinkerton, ... PLoS One 7 (4), e36261, 2012 | 45 | 2012 |
| Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies T Van Blarcom, K Lindquist, Z Melton, WL Cheung, C Wagstrom, ... MAbs 10 (2), 256-268, 2018 | 43 | 2018 |
| One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics W Chen, F Yang, C Wang, J Narula, E Pascua, I Ni, S Ding, X Deng, ... mAbs 13 (1), 1871171, 2021 | 42 | 2021 |
| Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire YA Yeung, D Foletti, X Deng, Y Abdiche, P Strop, J Glanville, S Pitts, ... Nature communications 7 (1), 1-14, 2016 | 42 | 2016 |
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