A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2570 | 2015 |
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP GS Lee, N Subramanian, AI Kim, I Aksentijevich, R Goldbach-Mansky, ... Nature 492 (7427), 123-127, 2012 | 1123 | 2012 |
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease DB Beck, MA Ferrada, KA Sikora, AK Ombrello, JC Collins, W Pei, ... New England Journal of Medicine 383 (27), 2628-2638, 2020 | 926 | 2020 |
Early-onset stroke and vasculopathy associated with mutations in ADA2 Q Zhou, D Yang, AK Ombrello, AV Zavialov, C Toro, AV Zavialov, ... New England Journal of Medicine 370 (10), 911-920, 2014 | 879 | 2014 |
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID … I Aksentijevich, M Nowak, M Mallah, JJ Chae, WT Watford, SR Hofmann, ... Arthritis & Rheumatism 46 (12), 3340-3348, 2002 | 873 | 2002 |
The B30. 2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production JJ Chae, G Wood, SL Masters, K Richard, G Park, BJ Smith, DL Kastner Proceedings of the National Academy of Sciences 103 (26), 9982-9987, 2006 | 757 | 2006 |
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ... Nature genetics 48 (1), 67-73, 2016 | 616 | 2016 |
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS YH Park, G Wood, DL Kastner, JJ Chae Nature immunology 17 (8), 914-921, 2016 | 600 | 2016 |
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis JJ Chae, HD Komarow, J Cheng, G Wood, N Raben, PP Liu, DL Kastner Molecular cell 11 (3), 591-604, 2003 | 570 | 2003 |
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice JJ Chae, YH Cho, GS Lee, J Cheng, PP Liu, L Feigenbaum, SI Katz, ... Immunity 34 (5), 755-768, 2011 | 527 | 2011 |
Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the … I Aksentijevich, Y Torosyan, J Samuels, M Centola, E Pras, JJ Chae, ... The American Journal of Human Genetics 64 (4), 949-962, 1999 | 381 | 1999 |
The pyrin inflammasome in health and disease O Schnappauf, JJ Chae, DL Kastner, I Aksentijevich Frontiers in immunology 10, 1745, 2019 | 363 | 2019 |
Familial mediterranean fever with a single MEFV mutation: Where is the second hit? MG Booty, JJ Chae, SL Masters, EF Remmers, B Barham, JM Le, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 359 | 2009 |
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production A Brehm, Y Liu, A Sheikh, B Marrero, E Omoyinmi, Q Zhou, ... The Journal of clinical investigation 125 (11), 4196-4211, 2015 | 322 | 2015 |
The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments E Mansfield, JJ Chae, HD Komarow, TM Brotz, DM Frucht, I Aksentijevich, ... Blood, The Journal of the American Society of Hematology 98 (3), 851-859, 2001 | 322 | 2001 |
Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy JJ Chae, I Aksentijevich, DL Kastner British journal of haematology 146 (5), 467-478, 2009 | 310 | 2009 |
The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations KM Hull, N Shoham, JJ Chae, I Aksentijevich, DL Kastner Current opinion in rheumatology 15 (1), 61-69, 2003 | 301 | 2003 |
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease N Lalaoui, SE Boyden, H Oda, GM Wood, DL Stone, D Chau, L Liu, ... Nature 577 (7788), 103-108, 2020 | 275 | 2020 |
Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease Q Zhou, X Yu, E Demirkaya, N Deuitch, D Stone, WL Tsai, HS Kuehn, ... Proceedings of the National Academy of Sciences 113 (36), 10127-10132, 2016 | 249 | 2016 |
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment JJ Chae, G Wood, K Richard, H Jaffe, NT Colburn, SL Masters, ... Blood, The Journal of the American Society of Hematology 112 (5), 1794-1803, 2008 | 228 | 2008 |