| Engineering exosomes as refined biological nanoplatforms for drug delivery X Luan, K Sansanaphongpricha, I Myers, H Chen, H Yuan, D Sun Acta Pharmacologica Sinica 38 (6), 754-763, 2017 | 1073 | 2017 |
| Why 90% of clinical drug development fails and how to improve it? D Sun, W Gao, H Hu, S Zhou Acta Pharmaceutica Sinica B 12 (7), 3049-3062, 2022 | 878 | 2022 |
| Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells Y Li, T Zhang, H Korkaya, S Liu, HF Lee, B Newman, Y Yu, SG Clouthier, ... Clinical Cancer Research 16 (9), 2580-2590, 2010 | 678 | 2010 |
| Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs D Sun, H Lennernas, LS Welage, JL Barnett, CP Landowski, D Foster, ... Pharmaceutical research 19, 1400-1416, 2002 | 507 | 2002 |
| A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo L Bai, H Zhou, R Xu, Y Zhao, K Chinnaswamy, D McEachern, J Chen, ... Cancer cell 36 (5), 498-511. e17, 2019 | 499 | 2019 |
| Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model X Cao, ST Gibbs, L Fang, HA Miller, CP Landowski, HC Shin, ... Pharmaceutical research 23, 1675-1686, 2006 | 453 | 2006 |
| A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells T Zhang, A Hamza, X Cao, B Wang, S Yu, CG Zhan, D Sun Molecular cancer therapeutics 7 (1), 162-170, 2008 | 442 | 2008 |
| Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression B Zhou, J Hu, F Xu, Z Chen, L Bai, E Fernandez-Salas, M Lin, L Liu, ... Journal of medicinal chemistry 61 (2), 462-481, 2018 | 392 | 2018 |
| Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo D Borkin, S He, H Miao, K Kempinska, J Pollock, J Chase, T Purohit, ... Cancer cell 27 (4), 589-602, 2015 | 381 | 2015 |
| Withaferin A targets heat shock protein 90 in pancreatic cancer cells Y Yu, A Hamza, T Zhang, M Gu, P Zou, B Newman, Y Li, AAL Gunatilaka, ... Biochemical pharmacology 79 (4), 542-551, 2010 | 357 | 2010 |
| Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast cancer W Li, T Tanikawa, I Kryczek, H Xia, G Li, KE Wu, S Wei, L Zhao, L Vatan, ... Cell metabolism 28 (1), 87-103. e6, 2018 | 354 | 2018 |
| A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment Q Cai, H Sun, Y Peng, J Lu, Z Nikolovska-Coleska, D McEachern, L Liu, ... Journal of medicinal chemistry 54 (8), 2714-2726, 2011 | 300 | 2011 |
| Disruption of 12/15-lipoxygenase expression in peritoneal macrophages: enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein D Sun, CD Funk Journal of Biological Chemistry 271 (39), 24055-24062, 1996 | 298 | 1996 |
| A potent small-molecule inhibitor of the MDM2–p53 interaction (MI-888) achieved complete and durable tumor regression in mice Y Zhao, S Yu, W Sun, L Liu, J Lu, D McEachern, S Shargary, D Bernard, ... Journal of medicinal chemistry 56 (13), 5553-5561, 2013 | 297 | 2013 |
| Discovery of QCA570 as an exceptionally potent and efficacious proteolysis targeting chimera (PROTAC) degrader of the bromodomain and extra-terminal (BET) proteins capable of … C Qin, Y Hu, B Zhou, E Fernandez-Salas, CY Yang, L Liu, D McEachern, ... Journal of medicinal chemistry 61 (15), 6685-6704, 2018 | 272 | 2018 |
| Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia X Cao, L Fang, S Gibbs, Y Huang, Z Dai, P Wen, X Zheng, W Sadee, ... Cancer chemotherapy and pharmacology 59, 495-505, 2007 | 263 | 2007 |
| Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors Y Zhao, L Liu, W Sun, J Lu, D McEachern, X Li, S Yu, D Bernard, ... Journal of the American Chemical Society 135 (19), 7223-7234, 2013 | 248 | 2013 |
| New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential Y Li, T Zhang, SJ Schwartz, D Sun Drug Resistance Updates 12 (1-2), 17-27, 2009 | 247 | 2009 |
| Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds Y Li, MS Wicha, SJ Schwartz, D Sun The Journal of nutritional biochemistry 22 (9), 799-806, 2011 | 234 | 2011 |
| Microbial metabolite signaling is required for systemic iron homeostasis NK Das, AJ Schwartz, G Barthel, N Inohara, Q Liu, A Sankar, DR Hill, ... Cell metabolism 31 (1), 115-130. e6, 2020 | 231 | 2020 |