| Discovery of a thermostable Baeyer–Villiger monooxygenase by genome mining MW Fraaije, J Wu, DPHM Heuts, EW van Hellemond, JHL Spelberg, ... Applied microbiology and biotechnology 66 (4), 393-400, 2005 | 320 | 2005 |
| Halohydrin dehalogenases are structurally and mechanistically related to short-chain dehydrogenases/reductases JET van Hylckama Vlieg, L Tang, JHL Spelberg, T Smilda, GJ Poelarends, ... Journal of bacteriology 183 (17), 5058-5066, 2001 | 215 | 2001 |
| Catalytic promiscuity of halohydrin dehalogenase and its application in enantioselective epoxide ring opening G Hasnaoui-Dijoux, M Majeric Elenkov, JH Lutje Spelberg, B Hauer, ... ChemBioChem 9 (7), 1048-1051, 2008 | 177 | 2008 |
| Directed evolution of epoxide hydrolase from A. radiobacter toward higher enantioselectivity by error-prone PCR and DNA shuffling B van Loo, JHL Spelberg, J Kingma, T Sonke, MG Wubbolts, DB Janssen Chemistry & biology 11 (7), 981-990, 2004 | 170 | 2004 |
| Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides JHL Spelberg, JET van Hylckama Vlieg, L Tang, DB Janssen, RM Kellogg Organic letters 3 (1), 41-43, 2001 | 170 | 2001 |
| A tandem enzyme reaction to produce optically active halohydrins, epoxides and diols JH Lutje Spelberg, JET van Hylckama Vlieg, T Bosma, RM Kellogg, ... Tetrahedron: Asymmetry 10 (15), 2863-2870, 1999 | 148 | 1999 |
| Enantioselectivity of a recombinant epoxide hydrolase from Agrobacterium radiobacter JHL Spelberg, R Rink, RM Kellogg, DB Janssen Tetrahedron: Asymmetry 9 (3), 459-466, 1998 | 136 | 1998 |
| Whole-cell biocatalysis: Evaluation of new hydrophobic ionic liquids for efficient asymmetric reduction of prochiral ketones S Bräutigam, D Dennewald, M Schürmann, J Lutje-Spelberg, WR Pitner, ... Enzyme and Microbial Technology 45 (4), 310-316, 2009 | 126 | 2009 |
| Exploration of the biocatalytic potential of a halohydrin dehalogenase using chromogenic substrates JHL Spelberg, L Tang, M van Gelder, RM Kellogg, DB Janssen Tetrahedron: Asymmetry 13 (10), 1083-1089, 2002 | 122 | 2002 |
| Characterization of the gene cluster involved in isoprene metabolism in Rhodococcus sp. strain AD45 JET van Hylckama Vlieg, H Leemhuis, JHL Spelberg, DB Janssen Journal of bacteriology 182 (7), 1956-1963, 2000 | 115 | 2000 |
| Tyrosine residues serve as proton donor in the catalytic mechanism of epoxide hydrolase from Agrobacterium radiobacter R Rink, J Kingma, JHL Spelberg, DB Janssen Biochemistry 39 (18), 5600-5613, 2000 | 93 | 2000 |
| Nitrite-mediated hydrolysis of epoxides catalyzed by halohydrin dehalogenase from< i> Agrobacterium radiobacter</i> AD1: a new tool for the kinetic resolution of epoxides G Hasnaoui, JH Lutje Spelberg, E de Vries, L Tang, B Hauer, DB Janssen Tetrahedron: Asymmetry 16 (9), 1685-1692, 2005 | 84 | 2005 |
| Enantioselective formation and ring-opening of epoxides catalysed by halohydrin dehalogenases D Janssen, M Majeric-Elenkov, G Hasnaoui, B Hauer, J Spelberg Biochemical Society Transactions 34, 291-295, 2006 | 80 | 2006 |
| Enzymatic dynamic kinetic resolution of epihalohydrins JH Lutje Spelberg, L Tang, RM Kellogg, DB Janssen Tetrahedron: Asymmetry 15 (7), 1095-1102, 2004 | 74 | 2004 |
| Enantioselective epoxidation and carbon–carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase A Tuynman, JL Spelberg, IM Kooter, HE Schoemaker, R Wever Journal of Biological Chemistry 275 (5), 3025-3030, 2000 | 73 | 2000 |
| A supramolecular cytochrome P450 mimic APHJ Schenning, JH Lutje Spelberg, DHW Hubert, MC Feiters, RJM Nolte Chemistry–A European Journal 4 (5), 871-880, 1998 | 71 | 1998 |
| Kinetic mechanism and enantioselectivity of halohydrin dehalogenase from Agrobacterium radiobacter L Tang, JHL Spelberg, MW Fraaije, DB Janssen Biochemistry 42 (18), 5378-5386, 2003 | 70 | 2003 |
| Stereo‐complementary two‐step cascades using a two‐enzyme system leading to enantiopure epoxides B Seisser, I Lavandera, K Faber, JHL Spelberg, W Kroutil Advanced Synthesis & Catalysis 349 (8‐9), 1399-1404, 2007 | 60 | 2007 |
| Steady-state kinetics and tryptophan fluorescence properties of halohydrin dehalogenase from Agrobacterium radiobacter. Roles of W139 and W249 in the active site and halide … L Tang, AEJ van Merode, JHL Spelberg, MW Fraaije, DB Janssen Biochemistry 42 (47), 14057-14065, 2003 | 60 | 2003 |
| Improved stability of halohydrin dehalogenase from< i> Agrobacterium radiobacter</i> AD1 by replacement of cysteine residues L Tang, JET van Hylckama Vlieg, JH Lutje Spelberg, MW Fraaije, ... Enzyme and microbial technology 30 (2), 251-258, 2002 | 54 | 2002 |
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