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Jau-Shyong Hong
Jau-Shyong Hong
Senior Investigator,NIH
Ingen verifierad e-postadress
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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
ML Block, L Zecca, JS Hong
Nature Reviews Neuroscience 8 (1), 57-69, 2007
48062007
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
L Qin, X Wu, ML Block, Y Liu, GR Breese, JS Hong, DJ Knapp, FT Crews
Glia 55 (5), 453-462, 2007
25082007
Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
ML Block, JS Hong
Progress in neurobiology 76 (2), 77-98, 2005
19372005
Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease
W Zhang, T Wang, Z Pei, DS Miller, X Wu, ML Block, B Wilson, W Zhang, ...
The FASEB Journal 19 (6), 533-542, 2005
14892005
Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
BIN Liu, JS Hong
The Journal of pharmacology and experimental therapeutics 304 (1), 1-7, 2003
13992003
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia
WG Kim, RP Mohney, B Wilson, GH Jeohn, B Liu, JS Hong
Journal of Neuroscience 20 (16), 6309-6316, 2000
11062000
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
HM Gao, JS Hong
Trends in immunology 29 (8), 357-365, 2008
9652008
Microglial activation‐mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
HM Gao, J Jiang, B Wilson, W Zhang, JS Hong, B Liu
Journal of neurochemistry 81 (6), 1285-1297, 2002
9302002
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
L Qin, Y Liu, T Wang, SJ Wei, ML Block, B Wilson, B Liu, JS Hong
Journal of Biological Chemistry 279 (2), 1415-1421, 2004
6992004
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
HJ Kim, M Rowe, M Ren, JS Hong, PS Chen, DM Chuang
The Journal of pharmacology and experimental therapeutics 321 (3), 892-901, 2007
6482007
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
L Qin, J He, RN Hanes, O Pluzarev, JS Hong, FT Crews
Journal of neuroinflammation 5, 1-17, 2008
6302008
Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
HM Gao, JS Hong, W Zhang, B Liu
Journal of Neuroscience 22 (3), 782-790, 2002
5602002
Role of nitric oxide in inflammation‐mediated neurodegeneration
BIN Liu, HUIM GAO, JIZYUH WANG, GHO JEOHN, CL Cooper, ...
Annals of the New York academy of sciences 962 (1), 318-331, 2002
5592002
Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
B Liu, L Du, JS Hong
The Journal of pharmacology and experimental therapeutics 293 (2), 607-617, 2000
4832000
Role of oxidative stress in epileptic seizures
EJ Shin, JH Jeong, YH Chung, WK Kim, KH Ko, JH Bach, JS Hong, ...
Neurochemistry international 59 (2), 122-137, 2011
4792011
Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
ML Block, X Wu, Z Pei, G Li, T Wang, L Qin, B Wilson, J Yang, JS Hong, ...
The FASEB journal 18 (13), 1618-1620, 2004
4492004
Chronic microglial activation and progressive dopaminergic neurotoxicity
ML Block, JS Hong
Biochemical Society Transactions 35 (5), 1127-1132, 2007
4352007
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
HM Gao, H Zhou, F Zhang, BC Wilson, W Kam, JS Hong
Journal of Neuroscience 31 (3), 1081-1092, 2011
4242011
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes
PS Chen, GS Peng, G Li, S Yang, X Wu, CC Wang, B Wilson, RB Lu, ...
Molecular psychiatry 11 (12), 1116-1125, 2006
4232006
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson’s disease
HM Gao, F Zhang, H Zhou, W Kam, B Wilson, JS Hong
Environmental health perspectives 119 (6), 807-814, 2011
4112011
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Artiklar 1–20