| Mutations in PCSK9 cause autosomal dominant hypercholesterolemia M Abifadel, M Varret, JP Rabès, D Allard, K Ouguerram, M Devillers, ... Nature genetics 34 (2), 154-156, 2003 | 3625 | 2003 |
| Chloroquine is a potent inhibitor of SARS coronavirus infection and spread MJ Vincent, E Bergeron, S Benjannet, BR Erickson, PE Rollin, TG Ksiazek, ... Virology journal 2, 1-10, 2005 | 2310 | 2005 |
| The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade B Coutard, C Valle, X De Lamballerie, B Canard, NG Seidah, E Decroly Antiviral research 176, 104742, 2020 | 2050 | 2020 |
| The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation NG Seidah, S Benjannet, L Wickham, J Marcinkiewicz, SB Jasmin, ... Proceedings of the National Academy of Sciences 100 (3), 928-933, 2003 | 1508 | 2003 |
| The Notch1 receptor is cleaved constitutively by a furin-like convertase F Logeat, C Bessia, C Brou, O LeBail, S Jarriault, NG Seidah, A Israël Proceedings of the National Academy of Sciences 95 (14), 8108-8112, 1998 | 1069 | 1998 |
| Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides NG Seidah, M Chrétien Brain research 848 (1-2), 45-62, 1999 | 945 | 1999 |
| The biology and therapeutic targeting of the proprotein convertases NG Seidah, A Prat Nature reviews Drug discovery 11 (5), 367-383, 2012 | 911 | 2012 |
| Automated design of ligands to polypharmacological profiles J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ... Nature 492 (7428), 215-220, 2012 | 876 | 2012 |
| NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol S Benjannet, D Rhainds, R Essalmani, J Mayne, L Wickham, W Jin, ... Journal of Biological Chemistry 279 (47), 48865-48875, 2004 | 809 | 2004 |
| PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. S Benjannet, N Rondeau, R Day, M Chretien, NG Seidah Proceedings of the National Academy of Sciences 88 (9), 3564-3568, 1991 | 793 | 1991 |
| Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia G Dubuc, A Chamberland, H Wassef, J Davignon, NG Seidah, L Bernier, ... Arteriosclerosis, thrombosis, and vascular biology 24 (8), 1454-1459, 2004 | 778 | 2004 |
| Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor SJ Mowla, HF Farhadi, S Pareek, JK Atwal, SJ Morris, NG Seidah, ... Journal of Biological Chemistry 276 (16), 12660-12666, 2001 | 773 | 2001 |
| PCSK9: a key modulator of cardiovascular health NG Seidah, Z Awan, M Chrétien, M Mbikay Circulation research 114 (6), 1022-1036, 2014 | 672 | 2014 |
| cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases NG Seidah, L Gaspar, P Mion, M Marcinkiewicz, M Mbikay, M Chretien DNA and cell biology 9 (6), 415-424, 1990 | 592 | 1990 |
| The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 S Poirier, G Mayer, S Benjannet, E Bergeron, J Marcinkiewicz, ... Journal of Biological Chemistry 283 (4), 2363-2372, 2008 | 559 | 2008 |
| Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution … NG Seidah, M Marcinkiewicz, S Benjannet, L Gaspar, G Beaubien, ... Molecular Endocrinology 5 (1), 111-122, 1991 | 558 | 1991 |
| The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions NG Seidah, M Chretien, R Day Biochimie 76 (3-4), 197-209, 1994 | 506 | 1994 |
| Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2 M Costa-Mattioli, D Gobert, H Harding, B Herdy, M Azzi, M Bruno, ... Nature 436 (7054), 1166-1170, 2005 | 491 | 2005 |
| Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases NG Seidah, S Benjannet, S Pareek, M Chrétien, RA Murphy FEBS letters 379 (3), 247-250, 1996 | 479 | 1996 |
| Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte‐specific low‐density lipoprotein receptor degradation and critical role in mouse liver regeneration A Zaid, A Roubtsova, R Essalmani, J Marcinkiewicz, A Chamberland, ... Hepatology 48 (2), 646-654, 2008 | 468 | 2008 |