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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia BJ Thompson, S Buonamici, ML Sulis, T Palomero, T Vilimas, G Basso, ... Journal of Experimental Medicine 204 (8), 1825-1835, 2007 | 577 | 2007 |
Molecular pathogenesis of T-cell leukaemia and lymphoma I Aifantis, E Raetz, S Buonamici Nature Reviews Immunology 8 (5), 380-390, 2008 | 543 | 2008 |
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma S Buonamici, J Williams, M Morrissey, A Wang, R Guo, A Vattay, K Hsiao, ... Science translational medicine 2 (51), 51ra70-51ra70, 2010 | 535 | 2010 |
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ... Nature medicine 24 (4), 497-504, 2018 | 519 | 2018 |
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ... Cell reports 13 (5), 1033-1045, 2015 | 494 | 2015 |
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia A Klinakis, C Lobry, O Abdel-Wahab, P Oh, H Haeno, S Buonamici, ... Nature 473 (7346), 230-233, 2011 | 436 | 2011 |
Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia T Vilimas, J Mascarenhas, T Palomero, M Mandal, S Buonamici, F Meng, ... Nature medicine 13 (1), 70-77, 2007 | 436 | 2007 |
Discovery of asciminib (ABL001), an allosteric inhibitor of the tyrosine kinase activity of BCR-ABL1 J Schoepfer, W Jahnke, G Berellini, S Buonamici, S Cotesta, ... Journal of Medicinal Chemistry 61 (18), 8120-8135, 2018 | 431 | 2018 |
Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ... Cell reports 23 (1), 282-296. e4, 2018 | 431 | 2018 |
Physiologic expression of Sf3b1K700E causes impaired erythropoiesis, aberrant splicing, and sensitivity to therapeutic spliceosome modulation EA Obeng, RJ Chappell, M Seiler, MC Chen, DR Campagna, PJ Schmidt, ... Cancer cell 30 (3), 404-417, 2016 | 408 | 2016 |
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins SCW Lee, H Dvinge, E Kim, H Cho, JB Micol, YR Chung, BH Durham, ... Nature medicine 22 (6), 672-678, 2016 | 394 | 2016 |
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia S Buonamici, T Trimarchi, MG Ruocco, L Reavie, S Cathelin, BG Mar, ... Nature 459 (7249), 1000-1004, 2009 | 315 | 2009 |
A crucial requirement for Hedgehog signaling in small cell lung cancer KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, ... Nature medicine 17 (11), 1504-1508, 2011 | 295 | 2011 |
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway Z Jagani, EL Mora-Blanco, CG Sansam, ES McKenna, B Wilson, D Chen, ... Nature medicine 16 (12), 1429-1433, 2010 | 271 | 2010 |
EVI1 induces myelodysplastic syndrome in mice S Buonamici, D Li, Y Chi, R Zhao, X Wang, L Brace, H Ni, ... The Journal of clinical investigation 114 (5), 713-719, 2004 | 239 | 2004 |
Hedgehog signaling is dispensable for adult hematopoietic stem cell function J Gao, S Graves, U Koch, S Liu, V Jankovic, S Buonamici, A El Andaloussi, ... Cell stem cell 4 (6), 548-558, 2009 | 236 | 2009 |
Synthetic lethal and convergent biological effects of cancer-associated spliceosomal gene mutations SCW Lee, K North, E Kim, E Jang, E Obeng, SX Lu, B Liu, D Inoue, ... Cancer cell 34 (2), 225-241. e8, 2018 | 232 | 2018 |
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