| Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells SM Nauli, FJ Alenghat, Y Luo, E Williams, P Vassilev, X Li, AEH Elia, ... Nature genetics 33 (2), 129-137, 2003 | 2448 | 2003 |
| Identification of mutations in the COL4A5 collagen gene in Alport syndrome DF Barker, SL Hostikka, J Zhou, LT Chow, AR Oliphant, SC Gerken, ... Science 248 (4960), 1224-1227, 1990 | 1051 | 1990 |
| Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids BS Freedman, CR Brooks, AQ Lam, H Fu, R Morizane, V Agrawal, ... Nature communications 6 (1), 8715, 2015 | 775 | 2015 |
| Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1 SM Nauli, Y Kawanabe, JJ Kaminski, WJ Pearce, DE Ingber, J Zhou Circulation 117 (9), 1161-1171, 2008 | 580 | 2008 |
| Polycystic kidney disease: the complete structure of the PKD1 gene and its protein International Polycystic Kidney Disease Consortium Cell 81 (2), 289-298, 1995 | 573* | 1995 |
| Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation W Lu, B Peissel, H Babakhanlou, A Pavlova, L Geng, X Fan, C Larson, ... Nature genetics 17 (2), 179-181, 1997 | 554 | 1997 |
| Genetic and Functional Studies Implicate HIF1α as a 14q Kidney Cancer Suppressor Gene C Shen, R Beroukhim, SE Schumacher, J Zhou, M Chang, S Signoretti, ... Cancer discovery 1 (3), 222-235, 2011 | 483 | 2011 |
| Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation TY Besschetnova, E Kolpakova-Hart, Y Guan, J Zhou, BR Olsen, JV Shah Current Biology 20 (2), 182-187, 2010 | 395 | 2010 |
| Deletion of the paired α5 (IV) and α6 (IV) collagen genes in inherited smooth muscle tumors J Zhou, T Mochizuki, H Smeets, C Antignac, P Laurila, A de Paepe, ... Science 261 (5125), 1167-1169, 1993 | 338 | 1993 |
| Polycystin-2 is a novel cation channel implicated in defective intracellular Ca2+ homeostasis in polycystic kidney disease PM Vassilev, L Guo, XZ Chen, Y Segal, JB Peng, N Basora, ... Biochemical and biophysical research communications 282 (1), 341-350, 2001 | 288 | 2001 |
| Polycystin-L is a calcium-regulated cation channel permeable to calcium ions XZ Chen, PM Vassilev, N Basora, JB Peng, H Nomura, Y Segal, ... Nature 401 (6751), 383-386, 1999 | 283 | 1999 |
| Polycystins and mechanosensation in renal and nodal cilia SM Nauli, J Zhou Bioessays 26 (8), 844-856, 2004 | 275 | 2004 |
| Identification and localization of polycystin, the PKD1 gene product. L Geng, Y Segal, B Peissel, N Deng, Y Pei, F Carone, HG Rennke, ... The Journal of clinical investigation 98 (12), 2674-2682, 1996 | 257 | 1996 |
| Polycystin-1 and polycystin-2 regulate the cell cycle through the helix–loop–helix inhibitor Id2 X Li, Y Luo, PG Starremans, CA McNamara, Y Pei, J Zhou Nature cell biology 7 (12), 1202-1212, 2005 | 254 | 2005 |
| Polycystins and primary cilia: primers for cell cycle progression J Zhou Annual review of physiology 71 (1), 83-113, 2009 | 252 | 2009 |
| Molecular genetics of Alport syndrome K Tryggvason, J Zhou, SL Hostikka, TB Shows Kidney international 43 (1), 38-44, 1993 | 238 | 1993 |
| Native Polycystin 2 Functions as a Plasma Membrane Ca2+-Permeable Cation Channel in Renal Epithelia Y Luo, PM Vassilev, X Li, Y Kawanabe, J Zhou Molecular and cellular biology 23 (7), 2600-2607, 2003 | 234 | 2003 |
| Renal injury is a third hit promoting rapid development of adult polycystic kidney disease A Takakura, L Contrino, X Zhou, JV Bonventre, Y Sun, BD Humphreys, ... Human molecular genetics 18 (14), 2523-2531, 2009 | 232 | 2009 |
| Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia S Wang, J Zhang, SM Nauli, X Li, PG Starremans, Y Luo, KA Roberts, ... Molecular and cellular biology 27 (8), 3241-3252, 2007 | 232 | 2007 |
| Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2 P Delmas, H Nomura, X Li, M Lakkis, Y Luo, Y Segal, ... Journal of Biological Chemistry 277 (13), 11276-11283, 2002 | 232 | 2002 |
Karl TryggvasonProfessor, Karolinska Institute, Stockholm & Duke-NUS, SingaporeVerifierad e-postadress på tryggvason.com