Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications EM Bachelder, TT Beaudette, KE Broaders, J Dashe, JMJ Fréchet Journal of the American Chemical Society 130 (32), 10494-10495, 2008 | 523 | 2008 |
Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy KE Broaders, JA Cohen, TT Beaudette, EM Bachelder, JMJ Fréchet Proceedings of the National Academy of Sciences 106 (14), 5497-5502, 2009 | 339 | 2009 |
A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer N Cheng, R Watkins-Schulz, RD Junkins, CN David, BM Johnson, ... JCI insight 3 (22), e120638, 2018 | 252 | 2018 |
Fully acid-degradable biocompatible polyacetal microparticles for drug delivery SE Paramonov, EM Bachelder, TT Beaudette, SM Standley, CC Lee, ... Bioconjugate Chemistry 19 (4), 911-919, 2008 | 225 | 2008 |
'Educated'dendritic cells act as messengers from memory to naive T helper cells O Alpan, E Bachelder, E Isil, H Arnheiter, P Matzinger Nature immunology 5 (6), 615-622, 2004 | 181 | 2004 |
In vitro analysis of acetalated dextran microparticles as a potent delivery platform for vaccine adjuvants EM Bachelder, TT Beaudette, KE Broaders, JMJ Fréchet, MT Albrecht, ... Molecular pharmaceutics 7 (3), 826-835, 2010 | 161 | 2010 |
A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination RD Junkins, MD Gallovic, BM Johnson, MA Collier, R Watkins-Schulz, ... Journal of Controlled Release 270, 1-13, 2018 | 153 | 2018 |
Acetalated dextran: a tunable and acid-labile biopolymer with facile synthesis and a range of applications EM Bachelder, EN Pino, KM Ainslie Chemical reviews 117 (3), 1915-1926, 2017 | 153 | 2017 |
Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells JA Cohen, TT Beaudette, JL Cohen, KE Broaders, EM Bachelder, ... Advanced materials (Deerfield Beach, Fla.) 22 (32), 3593, 2010 | 122 | 2010 |
TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae KS Lee, CA Scanga, EM Bachelder, Q Chen, CM Snapper Cellular immunology 245 (2), 103-110, 2007 | 113 | 2007 |
Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product KJ Kauffman, C Do, S Sharma, MD Gallovic, EM Bachelder, KM Ainslie ACS applied materials & interfaces 4 (8), 4149-4155, 2012 | 112 | 2012 |
Vaccine formulations in clinical development for the prevention of severe acute respiratory syndrome coronavirus 2 infection CJ Batty, MT Heise, EM Bachelder, KM Ainslie Advanced drug delivery reviews 169, 168-189, 2021 | 99 | 2021 |
Electrospray encapsulation of toll-like receptor agonist resiquimod in polymer microparticles for the treatment of visceral leishmaniasis AD Duong, S Sharma, KJ Peine, G Gupta, AR Satoskar, EM Bachelder, ... Molecular pharmaceutics 10 (3), 1045-1055, 2013 | 99 | 2013 |
Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo RT Steipel, MD Gallovic, CJ Batty, EM Bachelder, KM Ainslie Materials Science and Engineering: C 105, 110070, 2019 | 98 | 2019 |
In Vivo Studies on the Effect of Co-Encapsulation of CpG DNA and Antigen in Acid-Degradable Microparticle Vaccines TT Beaudette, EM Bachelder, JA Cohen, AC Obermeyer, KE Broaders, ... Molecular pharmaceutics 6 (4), 1160-1169, 2009 | 97 | 2009 |
T-Cell Activation by Antigen-Loaded pH-Sensitive Hydrogel Particles in Vivo: The Effect of Particle Size JA Cohen, TT Beaudette, WW Tseng, EM Bachelder, I Mende, ... Bioconjugate chemistry 20 (1), 111-119, 2009 | 95 | 2009 |
Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery SA Meenach, YJ Kim, KJ Kauffman, N Kanthamneni, EM Bachelder, ... Molecular pharmaceutics 9 (2), 290-298, 2012 | 90 | 2012 |
A microparticle platform for STING-targeted immunotherapy enhances natural killer cell-and CD8+ T cell-mediated anti-tumor immunity R Watkins-Schulz, P Tiet, MD Gallovic, RD Junkins, C Batty, ... Biomaterials 205, 94-105, 2019 | 88 | 2019 |
Microfabricated devices for enhanced bioadhesive drug delivery: attachment to and small‐molecule release through a cell monolayer under flow KM Ainslie, RD Lowe, TT Beaudette, L Petty, EM Bachelder, TA Desai Small 5 (24), 2857-2863, 2009 | 88 | 2009 |
Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses N Chen, MM Johnson, MA Collier, MD Gallovic, EM Bachelder, KM Ainslie Journal of Controlled Release 273, 147-159, 2018 | 87 | 2018 |