Structure–function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease S Tamir, ML Paddock, M Darash-Yahana-Baram, SH Holt, YS Sohn, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1853 (6), 1294-1315, 2015 | 179 | 2015 |
Redox-dependent gating of VDAC by mitoNEET CH Lipper, JT Stofleth, F Bai, YS Sohn, S Roy, R Mittler, R Nechushtai, ... Proceedings of the National Academy of Sciences 116 (40), 19924-19929, 2019 | 114 | 2019 |
The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer F Bai, F Morcos, YS Sohn, M Darash-Yahana, CO Rezende, CH Lipper, ... Proceedings of the National Academy of Sciences 112 (12), 3698-3703, 2015 | 93 | 2015 |
Cancer-related NEET proteins transfer 2Fe-2S clusters to anamorsin, a protein required for cytosolic iron-sulfur cluster biogenesis CH Lipper, ML Paddock, JN Onuchic, R Mittler, R Nechushtai, ... PLoS One 10 (10), e0139699, 2015 | 85 | 2015 |
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells CH Lipper, O Karmi, YS Sohn, M Darash-Yahana, H Lammert, L Song, ... Proceedings of the National Academy of Sciences 115 (2), 272-277, 2018 | 81 | 2018 |
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1 S Tamir, S Rotem-Bamberger, C Katz, F Morcos, KL Hailey, JA Zuris, ... Proceedings of the National Academy of Sciences 111 (14), 5177-5182, 2014 | 62 | 2014 |
Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs S Tamir, JA Zuris, L Agranat, CH Lipper, AR Conlan, D Michaeli, Y Harir, ... PLoS One 8 (5), e61202, 2013 | 57 | 2013 |
A point mutation in the [2Fe–2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties S Tamir, Y Eisenberg-Domovich, AR Conlan, JT Stofleth, CH Lipper, ... Biological Crystallography 70 (6), 1572-1578, 2014 | 40 | 2014 |
Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site CH Lipper, KH Gabriel, TCM Seegar, KL Dürr, MG Tomlinson, ... Structure 30 (2), 206-214. e4, 2022 | 23 | 2022 |
Structural basis for membrane-proximal proteolysis of substrates by ADAM10 CH Lipper, ED Egan, KH Gabriel, SC Blacklow Cell 186 (17), 3632-3641. e10, 2023 | 21 | 2023 |
Molecular dynamics simulations of the [2Fe–2S] cluster-binding domain of NEET proteins reveal key molecular determinants that induce their cluster transfer/release L Pesce, V Calandrini, H Marjault, CH Lipper, G Rossetti, R Mittler, ... The Journal of Physical Chemistry B 121 (47), 10648-10656, 2017 | 21 | 2017 |
IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation L Pan, ME Lemieux, T Thomas, JM Rogers, CH Lipper, W Lee, C Johnson, ... elife 9, e58081, 2020 | 19 | 2020 |
Design of high-affinity metal-controlled protein dimers B Maniaci, CH Lipper, DL Anipindi, H Erlandsen, JL Cole, B Stec, ... Biochemistry 58 (17), 2199-2207, 2019 | 11 | 2019 |
Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling DTD Jones, AN Dates, SD Rawson, MM Burruss, CH Lipper, SC Blacklow Nature Communications 14 (1), 2490, 2023 | 6 | 2023 |
Structural basis for selective proteolysis of ADAM10 substrates at membrane-proximal sites CH Lipper, ED Egan, KH Gabriel, SC Blacklow BioRxiv, 2022.10. 22.513345, 2022 | 4 | 2022 |
DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues KH Kock, PK Kimes, SS Gisselbrecht, S Inukai, SK Phanor, JT Anderson, ... Nature Communications 15 (1), 3110, 2024 | 3 | 2024 |
DNA binding analysis of rare variants in homeodomains reveals novel homeodomain specificity-determining residues KH Kock, PK Kimes, SS Gisselbrecht, S Inukai, SK Phanor, JT Anderson, ... bioRxiv, 2023.06. 16.545320, 2023 | 1 | 2023 |
Tethered agonist activated ADGRF1 structure reveals molecular preference for Gαq signalling DTD Jones, AN Dates, SD Rawson, MM Burruss, CH Lipper, SC Blacklow bioRxiv, 2022.09. 09.507336, 2022 | | 2022 |
Biochemical and Structural Characterization of the NEET Protein Family and their Role in Iron Homeostasis and Disease CH Lipper University of California, San Diego, 2017 | | 2017 |
The NEET Proteins Mediate Iron-Sulfur Cluster Transport from the Mitochondria to Cytosolic Proteins CH Lipper, ML Paddock, R Nechushtai, PA Jennings Biophysical Journal 110 (3), 549a, 2016 | | 2016 |