Прати
Dietrich Keppler
Dietrich Keppler
Professor Emeritus Heidelberg University and German Cancer Research Center
Верификована је имејл адреса на kabelbw.de
Наслов
Навело
Навело
Година
Membrane transporters in drug development
KM Giacomini, SM Huang, DJ Tweedie, LZ Benet, KLR Brouwer, X Chu, ...
Nature Reviews Drug Discovery 9 (3), 215-236, 2010
3623*2010
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
I Leier, G Jedlitschky, U Buchholz, SPC Cole, RG Deeley, D Keppler
Journal of Biological Chemistry 269 (45), 27807-27810, 1994
10981994
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
J König, AT Nies, Y Cui, I Leier, D Keppler
Biochimica et Biophysica Acta (BBA)-Biomembranes 1461 (2), 377-394, 1999
10111999
Glycogen determination with amyloglucosidase
D Keppler, K Decker
Methods of Enzymatic Analysis (Bergmeyer, HU, editor) 4, 1127-1131, 1974
904*1974
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
Y Cui, J König, U Buchholz, H Spring, I Leier, D Keppler
Molecular Pharmacology 55 (5), 929-937, 1999
8931999
cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
M Büchler, J König, M Brom, J Kartenbeck, H Spring, T Horie, D Keppler
Journal of Biological Chemistry 271 (25), 15091-15098, 1996
8201996
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
G Jedlitschky, I Leier, U Buchholz, K Barnouin, G Kurz, D Keppler
Cancer Research 56 (5), 988-994, 1996
7781996
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
J König, Y Cui, AT Nies, D Keppler
American Journal of Physiology-Gastrointestinal and Liver Physiology 278 (1 …, 2000
7762000
Experimental hepatitis induced by D-galactosamine
D Keppler, R Lesch, W Reutter, K Decker
Experimental and Molecular Pathology 9 (2), 279-290, 1968
7461968
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J König, Y Cui, AT Nies, D Keppler
Journal of Biological Chemistry 275 (30), 23161-23168, 2000
6542000
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6
Y Cui, J König, I Leier, U Buchholz, D Keppler
Journal of Biological Chemistry 276 (13), 9626-9630, 2001
6472001
Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
J König, D Rost, Y Cui, D Keppler
Hepatology 29 (4), 1156-1163, 1999
6231999
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
M Trauner, M Arrese, CJ Soroka, M Ananthanarayanan, TA Koeppel, ...
Gastroenterology 113 (1), 255-264, 1997
5881997
The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
G Jedlitschky, B Burchell, D Keppler
Journal of Biological Chemistry 275 (39), 30069-30074, 2000
5782000
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death
K Decker, D Keppler
Reviews of Physiology, Biochemistry and Pharmacology, Volume 71, 77-106, 1974
576*1974
ATP-dependent Transport of Glutathione S-Conjugates by the Multidrug Resistance-associated Protein
G Jedlitschky, I Leier, U Buchholz, M Center, D Keppler
Cancer Research 54 (18), 4833-4836, 1994
5711994
Absence of the canalicular isoform of the MRP gene–encoded conjugate export pump from the hepatocytes in Dubin‐Johnson syndrome
J Kartenbeck, U Leuschner, R Mayer, D Keppler
Hepatology 23 (5), 1061-1066, 1996
5181996
The apical conjugate efflux pump ABCC2 (MRP2)
AT Nies, D Keppler
Pflügers Archiv-European Journal of Physiology 453, 643-659, 2007
4912007
Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain
AT Nies, G Jedlitschky, J König, C Herold-Mende, HH Steiner, HP Schmitt, ...
Neuroscience 129 (2), 349-360, 2004
4802004
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
AT Nies, H Koepsell, S Winter, O Burk, K Klein, R Kerb, UM Zanger, ...
Hepatology 50 (4), 1227-1240, 2009
4622009
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