Rational design of cationic lipids for siRNA delivery SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ... Nature biotechnology 28 (2), 172-176, 2010 | 2036 | 2010 |
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ... Nature nanotechnology 14 (12), 1084-1087, 2019 | 1327 | 2019 |
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ... Angewandte Chemie International Edition 51 (34), 8529-8533, 2012 | 1317 | 2012 |
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination N Pardi, MJ Hogan, RS Pelc, H Muramatsu, H Andersen, CR DeMaso, ... Nature 543 (7644), 248-251, 2017 | 982 | 2017 |
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes N Pardi, S Tuyishime, H Muramatsu, K Kariko, BL Mui, YK Tam, ... Journal of Controlled Release 217, 345-351, 2015 | 963 | 2015 |
CAR T cells produced in vivo to treat cardiac injury JG Rurik, I Tombácz, A Yadegari, PO Méndez Fernández, SV Shewale, ... Science 375 (6576), 91-96, 2022 | 816 | 2022 |
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA NM Belliveau, J Huft, PJC Lin, S Chen, AKK Leung, TJ Leaver, AW Wild, ... Molecular therapy Nucleic acids 1, 2012 | 816 | 2012 |
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates K Musunuru, AC Chadwick, T Mizoguchi, SP Garcia, JE DeNizio, ... Nature 593 (7859), 429-434, 2021 | 637 | 2021 |
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics MA Maier, M Jayaraman, S Matsuda, J Liu, S Barros, W Querbes, YK Tam, ... Molecular Therapy 21 (8), 1570-1578, 2013 | 577 | 2013 |
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses N Pardi, MJ Hogan, MS Naradikian, K Parkhouse, DW Cain, L Jones, ... Journal of Experimental Medicine 215 (6), 1571-1588, 2018 | 527 | 2018 |
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses MG Alameh, I Tombácz, E Bettini, K Lederer, S Ndeupen, C Sittplangkoon, ... Immunity 54 (12), 2877-2892. e7, 2021 | 508 | 2021 |
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice PF McKay, K Hu, AK Blakney, K Samnuan, JC Brown, R Penn, J Zhou, ... Nature communications 11 (1), 3523, 2020 | 460 | 2020 |
Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles BL Mui, YK Tam, M Jayaraman, SM Ansell, X Du, YYC Tam, PJC Lin, ... Molecular Therapy Nucleic Acids 2, 2013 | 397 | 2013 |
SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation K Lederer, D Castaño, DG Atria, TH Oguin, S Wang, TB Manzoni, ... Immunity 53 (6), 1281-1295. e5, 2020 | 390 | 2020 |
D614G spike mutation increases SARS CoV-2 susceptibility to neutralization D Weissman, MG Alameh, T de Silva, P Collini, H Hornsby, R Brown, ... Cell host & microbe 29 (1), 23-31. e4, 2021 | 380 | 2021 |
A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice D Laczkó, MJ Hogan, SA Toulmin, P Hicks, K Lederer, BT Gaudette, ... Immunity 53 (4), 724-732. e7, 2020 | 374 | 2020 |
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge N Pardi, AJ Secreto, X Shan, F Debonera, J Glover, Y Yi, H Muramatsu, ... Nature communications 8 (1), 14630, 2017 | 352 | 2017 |
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA S Chen, YYC Tam, PJC Lin, MMH Sung, YK Tam, PR Cullis Journal of Controlled Release 235, 236-244, 2016 | 339 | 2016 |
Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92 G Maki, HG Klingemann, JA Martinson, YK Tam Journal of hematotherapy & stem cell research 10 (3), 369-383, 2001 | 332 | 2001 |
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels T Rothgangl, MK Dennis, PJC Lin, R Oka, D Witzigmann, L Villiger, W Qi, ... Nature biotechnology 39 (8), 949-957, 2021 | 303 | 2021 |