Spremljaj
Ying Tam
Ying Tam
Chief Scientific Officer, Acuitas Therapeutics
Preverjeni e-poštni naslov na acuitastx.com - Domača stran
Naslov
Navedeno
Navedeno
Leto
Rational design of cationic lipids for siRNA delivery
SC Semple, A Akinc, J Chen, AP Sandhu, BL Mui, CK Cho, DWY Sah, ...
Nature biotechnology 28 (2), 172-176, 2010
20362010
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
A Akinc, MA Maier, M Manoharan, K Fitzgerald, M Jayaraman, S Barros, ...
Nature nanotechnology 14 (12), 1084-1087, 2019
13272019
Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo
M Jayaraman, SM Ansell, BL Mui, YK Tam, J Chen, X Du, D Butler, ...
Angewandte Chemie International Edition 51 (34), 8529-8533, 2012
13172012
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
N Pardi, MJ Hogan, RS Pelc, H Muramatsu, H Andersen, CR DeMaso, ...
Nature 543 (7644), 248-251, 2017
9822017
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
N Pardi, S Tuyishime, H Muramatsu, K Kariko, BL Mui, YK Tam, ...
Journal of Controlled Release 217, 345-351, 2015
9632015
CAR T cells produced in vivo to treat cardiac injury
JG Rurik, I Tombácz, A Yadegari, PO Méndez Fernández, SV Shewale, ...
Science 375 (6576), 91-96, 2022
8162022
Microfluidic synthesis of highly potent limit-size lipid nanoparticles for in vivo delivery of siRNA
NM Belliveau, J Huft, PJC Lin, S Chen, AKK Leung, TJ Leaver, AW Wild, ...
Molecular therapy Nucleic acids 1, 2012
8162012
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
K Musunuru, AC Chadwick, T Mizoguchi, SP Garcia, JE DeNizio, ...
Nature 593 (7859), 429-434, 2021
6372021
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics
MA Maier, M Jayaraman, S Matsuda, J Liu, S Barros, W Querbes, YK Tam, ...
Molecular Therapy 21 (8), 1570-1578, 2013
5772013
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
N Pardi, MJ Hogan, MS Naradikian, K Parkhouse, DW Cain, L Jones, ...
Journal of Experimental Medicine 215 (6), 1571-1588, 2018
5272018
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
MG Alameh, I Tombácz, E Bettini, K Lederer, S Ndeupen, C Sittplangkoon, ...
Immunity 54 (12), 2877-2892. e7, 2021
5082021
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
PF McKay, K Hu, AK Blakney, K Samnuan, JC Brown, R Penn, J Zhou, ...
Nature communications 11 (1), 3523, 2020
4602020
Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles
BL Mui, YK Tam, M Jayaraman, SM Ansell, X Du, YYC Tam, PJC Lin, ...
Molecular Therapy Nucleic Acids 2, 2013
3972013
SARS-CoV-2 mRNA vaccines foster potent antigen-specific germinal center responses associated with neutralizing antibody generation
K Lederer, D Castaño, DG Atria, TH Oguin, S Wang, TB Manzoni, ...
Immunity 53 (6), 1281-1295. e5, 2020
3902020
D614G spike mutation increases SARS CoV-2 susceptibility to neutralization
D Weissman, MG Alameh, T de Silva, P Collini, H Hornsby, R Brown, ...
Cell host & microbe 29 (1), 23-31. e4, 2021
3802021
A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice
D Laczkó, MJ Hogan, SA Toulmin, P Hicks, K Lederer, BT Gaudette, ...
Immunity 53 (4), 724-732. e7, 2020
3742020
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
N Pardi, AJ Secreto, X Shan, F Debonera, J Glover, Y Yi, H Muramatsu, ...
Nature communications 8 (1), 14630, 2017
3522017
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
S Chen, YYC Tam, PJC Lin, MMH Sung, YK Tam, PR Cullis
Journal of Controlled Release 235, 236-244, 2016
3392016
Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92
G Maki, HG Klingemann, JA Martinson, YK Tam
Journal of hematotherapy & stem cell research 10 (3), 369-383, 2001
3322001
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
T Rothgangl, MK Dennis, PJC Lin, R Oka, D Witzigmann, L Villiger, W Qi, ...
Nature biotechnology 39 (8), 949-957, 2021
3032021
Sistem trenutno ne more izvesti postopka. Poskusite znova pozneje.
Članki 1–20