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Lei Shi
Lei Shi
National Institute on Drug Abuse - Intramural Research Program, NIH
Preverjeni e-poštni naslov na nih.gov - Domača stran
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Leto
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
EYT Chien, W Liu, Q Zhao, V Katritch, G Won Han, MA Hanson, L Shi, ...
Science 330 (6007), 1091-1095, 2010
13572010
Activation of the β2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6
JA Ballesteros, AD Jensen, G Liapakis, SGF Rasmussen, L Shi, U Gether, ...
Journal of Biological Chemistry 276 (31), 29171-29177, 2001
8342001
Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
JA Ballesteros, L Shi, JA Javitch
Molecular Pharmacology 60 (1), 1-19, 2001
5372001
β2 adrenergic receptor activation: Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
L Shi, G Liapakis, R Xu, F Guarnieri, JA Ballesteros, JA Javitch
Journal of Biological Chemistry 277 (43), 40989-40996, 2002
5162002
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism
C Saunders, JV Ferrer, L Shi, J Chen, G Merrill, ME Lamb, ...
Proceedings of the National Academy of Sciences 97 (12), 6850-6855, 2000
4852000
The mechanism of a neurotransmitter: sodium symporter—inward release of Na+ and substrate is triggered by substrate in a second binding site
L Shi, M Quick, Y Zhao, H Weinstein, JA Javitch
Molecular cell 30 (6), 667-677, 2008
4382008
The binding sites for cocaine and dopamine in the dopamine transporter overlap
T Beuming, J Kniazeff, ML Bergmann, L Shi, L Gracia, K Raniszewska, ...
Nature neuroscience 11 (7), 780-789, 2008
4282008
The binding site of aminergic G protein–coupled receptors: the transmembrane segments and second extracellular loop
L Shi, JA Javitch
Annual review of pharmacology and toxicology 42 (1), 437-467, 2002
4032002
Dopamine D2 receptors form higher order oligomers at physiological expression levels
W Guo, E Urizar, M Kralikova, JC Mobarec, L Shi, M Filizola, JA Javitch
The EMBO journal 27 (17), 2293-2304, 2008
3872008
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures
G Hao, B Derakhshan, L Shi, F Campagne, SS Gross
Proceedings of the National Academy of Sciences 103 (4), 1012-1017, 2006
3812006
The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer
W Guo, L Shi, JA Javitch
Journal of Biological Chemistry 278 (7), 4385-4388, 2003
3502003
Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment
I Kufareva, M Rueda, V Katritch, RC Stevens, R Abagyan
Structure 19 (8), 1108-1126, 2011
3432011
Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation
W Guo, L Shi, M Filizola, H Weinstein, JA Javitch
Proceedings of the National Academy of Sciences 102 (48), 17495-17500, 2005
3272005
A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and …
T Beuming, L Shi, JA Javitch, H Weinstein
Molecular pharmacology 70 (5), 1630-1642, 2006
3262006
Single-molecule dynamics of gating in a neurotransmitter transporter homologue
Y Zhao, D Terry, L Shi, H Weinstein, SC Blanchard, JA Javitch
Nature 465 (7295), 188-193, 2010
2892010
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
Y Zhao, DS Terry, L Shi, M Quick, H Weinstein, SC Blanchard, JA Javitch
Nature 474 (7349), 109-113, 2011
2592011
The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice
L Shi, JA Javitch
Proceedings of the National Academy of Sciences 101 (2), 440-445, 2004
2522004
Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells
S Pei, M Minhajuddin, KP Callahan, M Balys, JM Ashton, SJ Neering, ...
Journal of Biological Chemistry 288 (47), 33542-33558, 2013
2312013
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter: sodium symporters
DP Claxton, M Quick, L Shi, FD De Carvalho, H Weinstein, JA Javitch, ...
Nature structural & molecular biology 17 (7), 822-829, 2010
2092010
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation
M Quick, AML Winther, L Shi, P Nissen, H Weinstein, JA Javitch
Proceedings of the National Academy of Sciences 106 (14), 5563-5568, 2009
1962009
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