| Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 938 | 2015 |
| An efficient approach for screening minimal PKS genes from Streptomyces M Metsä-Ketelä, V Salo, L Halo, A Hautala, J Hakala, P Mäntsälä, ... FEMS Microbiology Letters 180 (1), 1-6, 1999 | 239 | 1999 |
| Activation of microbial secondary metabolic pathways: Avenues and challenges B Baral, A Akhgari, M Metsä-Ketelä Synthetic and Systems Biotechnology 3 (3), 163-178, 2018 | 221 | 2018 |
| Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various Streptomyces species M Metsä-Ketelä, L Halo, E Munukka, J Hakala, P Mäntsälä, ... Applied and Environmental Microbiology 68 (9), 4472-4479, 2002 | 169 | 2002 |
| Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection F Guo, S Xiang, L Li, B Wang, J Rajasärkkä, K Gröndahl-Yli-Hannuksela, ... Metabolic Engineering 28, 134-142, 2015 | 96 | 2015 |
| Anthracyclines: biosynthesis, engineering and clinical applications MB Hulst, T Grocholski, JJC Neefjes, GP van Wezel, M Metsä-Ketelä Natural product reports 39 (4), 814-841, 2022 | 84 | 2022 |
| Engineering anthracycline biosynthesis toward angucyclines M Metsä-Ketelä, K Palmu, T Kunnari, K Ylihonko, P Mäntsälä Antimicrobial agents and chemotherapy 47 (4), 1291-1296, 2003 | 80 | 2003 |
| Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis G Schneider, J Niemi J. Mol. Biol 372, 633-648, 2007 | 75 | 2007 |
| Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis T Oja, K Palmu, H Lehmussola, O Leppäranta, K Hännikäinen, J Niemi, ... Chemistry & biology 15 (10), 1046-1057, 2008 | 71 | 2008 |
| Partial activation of a silent angucycline-type gene cluster from a rubromycin β producing Streptomyces sp. PGA64 M Metsä-Ketelä, K Ylihonko, P Mäntsälä The Journal of antibiotics 57 (8), 502-510, 2004 | 67 | 2004 |
| Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway V Siitonen, B Selvaraj, L Niiranen, Y Lindqvist, G Schneider, ... Proceedings of the National Academy of Sciences 113 (19), 5251-5256, 2016 | 59 | 2016 |
| Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics T Taguchi, M Yabe, H Odaki, M Shinozaki, M Metsä-Ketelä, T Arai, ... Chemistry & Biology 20 (4), 510-520, 2013 | 59 | 2013 |
| Effective antibiofilm polyketides against Staphylococcus aureus from the pyranonaphthoquinone biosynthetic pathways of Streptomyces species T Oja, P San Martin Galindo, T Taguchi, S Manner, PM Vuorela, ... Antimicrobial Agents and Chemotherapy 59 (10), 6046-6052, 2015 | 54 | 2015 |
| Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities N Ueberschaar, Z Xu, K Scherlach, M Metsa-Ketela, T Bretschneider, ... Journal of the American Chemical Society 135 (46), 17408-17416, 2013 | 54 | 2013 |
| Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways K Palmu, K Ishida, P Mäntsälä, C Hertweck, M Metsä‐Ketelä ChemBioChem 8 (13), 1577-1584, 2007 | 54 | 2007 |
| Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C P Kallio, Z Liu, P Mäntsälä, J Niemi, M Metsä-Ketelä Chemistry & biology 15 (2), 157-166, 2008 | 51 | 2008 |
| Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis V Siitonen, B Blauenburg, P Kallio, P Mäntsälä, M Metsä-Ketelä Chemistry & biology 19 (5), 638-646, 2012 | 47 | 2012 |
| Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics K Palmu, P Rosenqvist, K Thapa, Y Ilina, V Siitonen, B Baral, J Makinen, ... ACS chemical biology 12 (6), 1472-1477, 2017 | 46 | 2017 |
| Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for CC bond formation and cleavage T Oja, KD Klika, L Appassamy, J Sinkkonen, P Mäntsälä, J Niemi, ... Proceedings of the National Academy of Sciences 109 (16), 6024-6029, 2012 | 46 | 2012 |
| Identification of late‐stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin V Siitonen, M Claesson, P Patrikainen, M Aromaa, P Mäntsälä, ... ChemBioChem 13 (1), 120-128, 2012 | 46 | 2012 |
Vilja SiitonenSenior Researcher, University of TurkuPreverjeni e-poštni naslov na utu.fi
