| Precise engineering of siRNA delivery vehicles to tumors using polyion complexes and gold nanoparticles HJ Kim, H Takemoto, Y Yi, M Zheng, Y Maeda, H Chaya, K Hayashi, P Mi, ... ACS nano 8 (9), 8979-8991, 2014 | 145 | 2014 |
| Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles F Pittella, H Cabral, Y Maeda, P Mi, S Watanabe, H Takemoto, HJ Kim, ... Journal of controlled release 178, 18-24, 2014 | 137 | 2014 |
| Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system H Takemoto, A Ishii, K Miyata, M Nakanishi, M Oba, T Ishii, Y Yamasaki, ... Biomaterials 31 (31), 8097-8105, 2010 | 136 | 2010 |
| Acidic pH-responsive siRNA conjugate for reversible carrier stability and accelerated endosomal escape with reduced IFNα-associated immune response. H Takemoto, K Miyata, S Hattori, T Ishii, T Suma, S Uchida, N Nishiyama, ... Angewandte Chemie International Edition 52 (24), 2013 | 133 | 2013 |
| Smart multilayered assembly for biocompatible siRNA delivery featuring dissolvable silica, endosome-disrupting polycation, and detachable PEG T Suma, K Miyata, Y Anraku, S Watanabe, RJ Christie, H Takemoto, ... ACS nano 6 (8), 6693-6705, 2012 | 112 | 2012 |
| Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism T Nomoto, Y Inoue, Y Yao, M Suzuki, K Kanamori, H Takemoto, M Matsui, ... Science Advances 6 (4), eaaz1722, 2020 | 110 | 2020 |
| Targeted systemic delivery of siRNA to cervical cancer model using cyclic RGD-installed unimer polyion complex-assembled gold nanoparticles Y Yi, HJ Kim, P Mi, M Zheng, H Takemoto, K Toh, BS Kim, K Hayashi, ... Journal of Controlled Release 244, 247-256, 2016 | 107 | 2016 |
| Influence of RNA strand rigidity on polyion complex formation with block catiomers K Hayashi, H Chaya, S Fukushima, S Watanabe, H Takemoto, K Osada, ... Macromolecular Rapid Communications 37 (6), 486-493, 2016 | 81 | 2016 |
| In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers S Watanabe, K Hayashi, K Toh, HJ Kim, X Liu, H Chaya, S Fukushima, ... Nature communications 10 (1), 1894, 2019 | 74 | 2019 |
| An ethylenediamine‐based switch to render the polyzwitterion cationic at tumorous pH for effective tumor accumulation of coated nanomaterials AH Ranneh, H Takemoto, S Sakuma, A Awaad, T Nomoto, Y Mochida, ... Angewandte Chemie 130 (18), 5151-5155, 2018 | 60 | 2018 |
| siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting … M Tangsangasaksri, H Takemoto, M Naito, Y Maeda, D Sueyoshi, HJ Kim, ... Biomacromolecules 17 (1), 246-255, 2016 | 60 | 2016 |
| Fine‐Tuning of Charge‐Conversion Polymer Structure for Efficient Endosomal Escape of siRNA‐Loaded Calcium Phosphate Hybrid Micelles Y Maeda, F Pittella, T Nomoto, H Takemoto, N Nishiyama, K Miyata, ... Macromolecular rapid communications 35 (13), 1211-1215, 2014 | 56 | 2014 |
| Accelerated polymer–polymer click conjugation by freeze–thaw treatment H Takemoto, K Miyata, T Ishii, S Hattori, S Osawa, N Nishiyama, ... Bioconjugate chemistry 23 (8), 1503-1506, 2012 | 45 | 2012 |
| Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine K Komoto, T Nomoto, S El Muttaqien, H Takemoto, M Matsui, Y Miura, ... Cancer science 112 (1), 410-421, 2021 | 44 | 2021 |
| Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers X Dou, T Nomoto, H Takemoto, M Matsui, K Tomoda, N Nishiyama Scientific Reports 8 (1), 8126, 2018 | 41 | 2018 |
| Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof K Kataoka, N Nishiyama, A Ishii, Y Kato, K Miyata, H Kim, H Takemoto US Patent 8,431,545, 2013 | 37 | 2013 |
| Sequential self-assembly using tannic acid and phenylboronic acid-modified copolymers for potential protein delivery Y Honda, T Nomoto, M Matsui, H Takemoto, Y Kaihara, Y Miura, ... Biomacromolecules 21 (9), 3826-3835, 2020 | 36 | 2020 |
| Enhanced transfection with silica-coated polyplexes loading plasmid DNA K Miyata, N Gouda, H Takemoto, M Oba, Y Lee, H Koyama, Y Yamasaki, ... Biomaterials 31 (17), 4764-4770, 2010 | 36 | 2010 |
| pH-responsive polyzwitterion covered nanocarriers for DNA delivery X Shen, A Dirisala, M Toyoda, Y Xiao, H Guo, Y Honda, T Nomoto, ... Journal of Ophthalmology Clinics and Research 360, 928-939, 2023 | 29 | 2023 |
| Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy T Nomoto, Y Yao, Y Inoue, M Suzuki, K Kanamori, H Takemoto, M Matsui, ... Journal of Controlled Release 332, 184-193, 2021 | 29 | 2021 |