| Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery E Marsault, ML Peterson Journal of medicinal chemistry 54 (7), 1961-2004, 2011 | 967 | 2011 |
| Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides ML Peterson, R Vince Journal of medicinal chemistry 34 (9), 2787-2797, 1991 | 115 | 1991 |
| Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from hit to clinic HR Hoveyda, E Marsault, R Gagnon, AP Mathieu, M Vézina, A Landry, ... Journal of medicinal chemistry 54 (24), 8305-8320, 2011 | 90 | 2011 |
| Methods of using macrocyclic modulators of the ghrelin receptor GL Fraser, HR Hoveyda, ML Peterson US Patent 7,491,695, 2009 | 84 | 2009 |
| Discovery of a new class of macrocyclic antagonists to the human motilin receptor E Marsault, HR Hoveyda, ML Peterson, C Saint-Louis, A Landry, ... Journal of medicinal chemistry 49 (24), 7190-7197, 2006 | 79 | 2006 |
| Macrocyclic modulators of the ghrelin receptor HR Hoveyda, ML Peterson, GL Fraser, M Ramaseshan US Patent 7,476,653, 2009 | 59 | 2009 |
| Practical Medicinal Chemistry with Macrocycles: Design, Synthesis, and Case Studies E Marsault, ML Peterson John Wiley & Sons, 2017 | 57 | 2017 |
| Efficient parallel synthesis of macrocyclic peptidomimetics E Marsault, HR Hoveyda, R Gagnon, ML Peterson, M Vézina, ... Bioorganic & medicinal chemistry letters 18 (16), 4731-4735, 2008 | 52 | 2008 |
| Macrocyclic antagonists of the motilin receptor GL Fraser, É Marsault, M Peterson, H Hoveyda, S Beaubien, K Benakli, ... US Patent 7,521,420, 2009 | 42 | 2009 |
| Synthesis and biological evaluation of carbocyclic analogs of lyxofuranosides of 2-amino-6-substituted purines and 2-amino-6-substituted-8-azapurines ML Peterson, R Vince Journal of medicinal chemistry 33 (4), 1214-1219, 1990 | 40 | 1990 |
| Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same HR Hoveyda, E Marsault, H Thomas, G Fraser, S Beaubien, A Mathieu, ... US Patent App. 12/916,205, 2011 | 33 | 2011 |
| Spatially-defined macrocycles incorporating peptide bond surrogates P Deslongchamps, Y Dory, L Ouellet, G Villeneuve, M Ramaseshan, ... US Patent 7,550,431, 2009 | 26 | 2009 |
| Methods of using macrocyclic modulators of the ghrelin receptor GL Fraser, HR Hoveyda, ML Peterson US Patent 8,450,268, 2013 | 25 | 2013 |
| Intermediates for macrocyclic compounds E Marsault, K Benakli, H Hoveyda, ML Peterson, S Beaubien, L Ouellet, ... US Patent 10,040,751, 2018 | 23* | 2018 |
| Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders GL Fraser, HR Hoveyda, ML Peterson US Patent 8,088,733, 2012 | 23 | 2012 |
| Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR LM Stevers, M Wolter, GW Carlile, D Macdonald, L Richard, F Gielkens, ... Nature communications 13 (1), 1-9, 2022 | 19 | 2022 |
| Conformationally-controlled biologically active macrocyclic small molecules as motilin antagonists or ghrelin agonists P Deslongchamps, Y Dory, M Peterson, K Benakli, E Marsault, L Ouellet, ... US Patent 7,452,862, 2008 | 18 | 2008 |
| Deconvolution by omission libraries E Câmpian, ML Peterson, HH Saneii, Á Furka Bioorganic & medicinal chemistry letters 8 (17), 2357-2362, 1998 | 18 | 1998 |
| Methods of using macrocyclic modulators of the ghrelin receptor GL Fraser, HR Hoveyda, ML Peterson US Patent App. 12/635,871, 2011 | 16 | 2011 |
| Macrocyclic modulators of the ghrelin receptor H Hoveyda, ML Peterson, GL Fraser, M Ramaseshan US Patent App. 12/636,048, 2010 | 16 | 2010 |
