Delivery of therapeutic oligonucleotides with cell penetrating peptides P Boisguérin, S Deshayes, MJ Gait, L O'Donovan, C Godfrey, CA Betts, ... Advanced drug delivery reviews 87, 52-67, 2015 | 281 | 2015 |
A chemical view of oligonucleotides for exon skipping and related drug applications P Järver, L O'Donovan, MJ Gait Nucleic Acid Therapeutics 24 (1), 37-47, 2014 | 173 | 2014 |
How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse C Godfrey, S Muses, G McClorey, KE Wells, T Coursindel, RL Terry, ... Human molecular genetics 24 (15), 4225-4237, 2015 | 148 | 2015 |
Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides K Ezzat, Y Aoki, T Koo, G McClorey, L Benner, A Coenen-Stass, ... Nano letters 15 (7), 4364-4373, 2015 | 115 | 2015 |
Development and application of an ultrasensitive hybridization-based ELISA method for the determination of peptide-conjugated phosphorodiamidate morpholino oligonucleotides U Burki, J Keane, A Blain, L O'Donovan, MJ Gait, SH Laval, V Straub Nucleic acid therapeutics 25 (5), 275-284, 2015 | 59 | 2015 |
Comprehensive RNA-sequencing analysis in serum and muscle reveals novel small RNA signatures with biomarker potential for DMD AML Coenen-Stass, H Sork, S Gatto, C Godfrey, A Bhomra, K Krjutškov, ... Molecular Therapy-Nucleic Acids 13, 1-15, 2018 | 50 | 2018 |
The influence of the aziridinyl substituent of benzimidazoles and benzimidazolequinones on toxicity towards normal and Fanconi anaemia cells K Fahey, L O'Donovan, M Carr, MP Carty, F Aldabbagh European journal of medicinal chemistry 45 (5), 1873-1879, 2010 | 39 | 2010 |
First synthesis of an aziridinyl fused pyrrolo [1, 2-a] benzimidazole and toxicity evaluation towards normal and breast cancer cell lines S Bonham, L O'Donovan, MP Carty, F Aldabbagh Organic & Biomolecular Chemistry 9 (19), 6700-6706, 2011 | 25 | 2011 |
Synthesis of dimethyl substituted benzimidazoles containing cyclopropane fused onto five to eight membered [1, 2-a] alicyclic rings and influence of methyl group substituents … S Hehir, L O'Donovan, MP Carty, F Aldabbagh Tetrahedron 64 (19), 4196-4203, 2008 | 24 | 2008 |
Parallel synthesis of cell-penetrating peptide conjugates of PMO toward exon skipping enhancement in Duchenne muscular dystrophy L O'Donovan, I Okamoto, AA Arzumanov, DL Williams, P Deuss, MJ Gait Nucleic acid therapeutics 25 (1), 1-10, 2015 | 23 | 2015 |
Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne … AM Blain, E Greally, G McClorey, R Manzano, CA Betts, C Godfrey, ... PLoS One 13 (6), e0198897, 2018 | 22 | 2018 |
Cmah-dystrophin deficient mdx mice display an accelerated cardiac phenotype that is improved following peptide-PMO exon skipping treatment CA Betts, G McClorey, R Healicon, SM Hammond, R Manzano, S Muses, ... Human Molecular Genetics 28 (3), 396-406, 2019 | 18 | 2019 |
First synthesis of N-[(aziridin-2-yl) methyl] benzimidazolequinone and analysis of toxicity towards normal and Fanconi anemia cells L O’Donovan, MP Carty, F Aldabbagh Chemical communications, 5592-5594, 2008 | 17 | 2008 |
A photocleavable linker for the chemoselective functionalization of biomaterials L O'Donovan, A Paul Journal of Materials Chemistry 22 (41), 21878-21884, 2012 | 12 | 2012 |
A hydrazide-anchored dendron scaffold for chemoselective ligation strategies L O'Donovan, A Paul Organic & Biomolecular Chemistry 12 (37), 7290-7296, 2014 | 9 | 2014 |
In vitro assays to assess exon skipping in duchenne muscular dystrophy P Boisguerin, L O’Donovan, MJ Gait, B Lebleu Cell-Penetrating Peptides: Methods and Protocols, 317-329, 2015 | 7 | 2015 |
Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation D Gupta, S Orehek, J Turunen, L O’Donovan, MJ Gait, S El-Andaloussi, ... Cells 12 (18), 2285, 2023 | 4 | 2023 |
Cell-penetrating peptide conjugates and methods of their use M Wood, R Manzano, C Godfrey, G McClorey, R Raz, M Gait, ... US Patent App. 18/277,013, 2024 | | 2024 |
Cell-penetrating peptides M Wood, R Manzano, C Godfrey, G McClorey, R Raz, M Gait, ... US Patent App. 17/266,939, 2021 | | 2021 |
Cell-penetrating peptides M Wood, S El Andaloussi, G McClorey, R Manzano, MJ Gait, C Godfrey, ... US Patent App. 17/266,940, 2021 | | 2021 |