| Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer’s disease B Zhang, C Gaiteri, LG Bodea, Z Wang, J McElwee, AA Podtelezhnikov, ... Cell 153 (3), 707-720, 2013 | 1854 | 2013 |
| Activated STING in a vascular and pulmonary syndrome Y Liu, AA Jesus, B Marrero, D Yang, SE Ramsey, ... New England Journal of Medicine 371 (6), 507-518, 2014 | 1357 | 2014 |
| Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4 HS Kuehn, W Ouyang, B Lo, EK Deenick, JE Niemela, DT Avery, ... Science 345 (6204), 1623-1627, 2014 | 950 | 2014 |
| IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases MWL Teng, EP Bowman, JJ McElwee, MJ Smyth, JL Casanova, ... Nature medicine 21 (7), 719-729, 2015 | 947 | 2015 |
| Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila C Burnett, S Valentini, F Cabreiro, M Goss, M Somogyvári, MD Piper, ... nature 477 (7365), 482-485, 2011 | 771 | 2011 |
| Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy B Lo, K Zhang, W Lu, L Zheng, Q Zhang, C Kanellopoulou, Y Zhang, Z Liu, ... Science 349 (6246), 436-440, 2015 | 726 | 2015 |
| Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations JD Milner, TP Vogel, L Forbes, CA Ma, A Stray-Pedersen, JE Niemela, ... Blood, The Journal of the American Society of Hematology 125 (4), 591-599, 2015 | 602 | 2015 |
| Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans R Doonan, JJ McElwee, F Matthijssens, GA Walker, K Houthoofd, P Back, ... Genes & development 22 (23), 3236-3241, 2008 | 574 | 2008 |
| Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16 J McElwee, K Bubb, JH Thomas Aging cell 2 (2), 111-121, 2003 | 508 | 2003 |
| Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance JJ McElwee, E Schuster, E Blanc, JH Thomas, D Gems Journal of Biological Chemistry 279 (43), 44533-44543, 2004 | 473 | 2004 |
| Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number JJ Lyons, X Yu, JD Hughes, QT Le, A Jamil, Y Bai, N Ho, M Zhao, Y Liu, ... Nature genetics 48 (12), 1564-1569, 2016 | 357 | 2016 |
| Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K CL Lucas, Y Zhang, A Venida, Y Wang, J Hughes, J McElwee, M Butrick, ... Journal of Experimental Medicine 211 (13), 2537-2547, 2014 | 312 | 2014 |
| Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment Y Zhang, X Yu, M Ichikawa, JJ Lyons, S Datta, IT Lamborn, H Jing, ES Kim, ... Journal of Allergy and Clinical Immunology 133 (5), 1400-1409. e5, 2014 | 261 | 2014 |
| Evolutionary conservation of regulated longevity assurance mechanisms JJ McElwee, E Schuster, E Blanc, MD Piper, JH Thomas, DS Patel, ... Genome biology 8, 1-16, 2007 | 260 | 2007 |
| Germline hypomorphic CARD11 mutations in severe atopic disease CA Ma, JR Stinson, Y Zhang, JK Abbott, MA Weinreich, PJ Hauk, ... Nature genetics 49 (8), 1192-1201, 2017 | 232 | 2017 |
| Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? MDW Piper, C Selman, JJ McElwee, L Partridge Journal of internal medicine 263 (2), 179-191, 2008 | 201 | 2008 |
| Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases M Narayanan, JL Huynh, K Wang, X Yang, S Yoo, J McElwee, B Zhang, ... Molecular systems biology 10 (7), 743, 2014 | 193 | 2014 |
| CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis A Ozen, WA Comrie, RC Ardy, C Domínguez Conde, B Dalgic, ÖF Beser, ... New England Journal of Medicine 377 (1), 52-61, 2017 | 187 | 2017 |
| Phenome-wide association studies across large population cohorts support drug target validation D Diogo, C Tian, CS Franklin, M Alanne-Kinnunen, M March, ... Nature communications 9 (1), 1-13, 2018 | 184 | 2018 |
| Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling? D Gems, JJ McElwee Mechanisms of ageing and development 126 (3), 381-387, 2005 | 176 | 2005 |
