Motohashi Hozumi

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Masayuki YamamotoTohoku University, ProfessorEmail confirmado em tohoku.ac.jp
James EngelUniversity of MichiganEmail confirmado em umich.edu
Keiko TaguchiThe University of TokyoEmail confirmado em med.tohoku.ac.jp
Takafumi SuzukiTohoku University Graduate School of MedicineEmail confirmado em med.tohoku.ac.jp
Kazuhiko IgarashiDepartment of Biochemistry, Tohoku University Graduate School of MedicineEmail confirmado em med.tohoku.ac.jp
Tetsuro MatsunagaProfessor, Akita UniversityEmail confirmado em med.tohoku.ac.jp
Hiroyuki AburataniRCAST, The University of TokyoEmail confirmado em umin.ac.jp
Hideshi IharaOsaka Prefecture UniversityEmail confirmado em b.s.osakafu-u.ac.jp
Akira KobayashiProfessor of Molecular Biology, Doshisha UniversityEmail confirmado em mail.doshisha.ac.jp
Thomas KenslerJohns Hopkins UniversityEmail confirmado em jhu.edu
Satoru TakahashiUniversity of TsukubaEmail confirmado em md.tsukuba.ac.jp
Tatsuhiro ShibataLaboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, JapanEmail confirmado em ncc.go.jp
Nobuyuki Tanaka宮城県立がんセンター　東北大学Email confirmado em med.tohoku.ac.jp
Jordan ShavitProfessor of Pediatrics, University of MichiganEmail confirmado em umich.edu
Wakabayashi NobunaoFred Hutchinson Cancer Research CenterEmail confirmado em fredhutch.org
Tomonori HosoyaEmail confirmado em umich.edu
Hideto Hoshino / 星野英人National Institute of Advanced Industrial Science and technology (AIST)Email confirmado em aist.go.jp
Hiroshi KuboOlympus CorporationEmail confirmado em med.tohoku.ac.jp
paul-henri romeodirecteur de recherche InsermEmail confirmado em cea.fr
Salil LachkeAlumni Distinguished Professor, University of DelawareEmail confirmado em udel.edu

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Motohashi Hozumi

Institute of Development, Aging and Cancer, Tohoku University

Email confirmado em tohoku.ac.jp - Página inicial

Transcriptional regulation


Título Ordenar por citações Ordenar por ano Ordenar por título	Citado por Citado por	Ano
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ... Nature cell biology 12 (3), 213-223, 2010	2525	2010
Nrf2–Keap1 defines a physiologically important stress response mechanism H Motohashi, M Yamamoto Trends in molecular medicine 10 (11), 549-557, 2004	2018	2004
A promoter-level mammalian expression atlas Nature 507 (7493), 462-470, 2014	1814	2014
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution K Taguchi, H Motohashi, M Yamamoto Genes to cells 16 (2), 123-140, 2011	1780	2011
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, ... Nature communications 7 (1), 11624, 2016	1650	2016
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis M Yamamoto, TW Kensler, H Motohashi Physiological reviews 98 (3), 1169-1203, 2018	1528	2018
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ... Cancer cell 22 (1), 66-79, 2012	1466	2012
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy Y Ichimura, S Waguri, Y Sou, S Kageyama, J Hasegawa, R Ishimura, ... Molecular cell 51 (5), 618-631, 2013	1171	2013
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation N Wakabayashi, K Itoh, J Wakabayashi, H Motohashi, S Noda, ... Nature genetics 35 (3), 238-245, 2003	1027	2003
Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling T Ida, T Sawa, H Ihara, Y Tsuchiya, Y Watanabe, Y Kumagai, M Suematsu, ... Proceedings of the National Academy of Sciences 111 (21), 7606-7611, 2014	939	2014
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, ... Journal of Biological Chemistry 278 (10), 8135-8145, 2003	827	2003
Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site T Oyake, K Itoh, H Motohashi, N Hayashi, H Hoshino, M Nishizawa, ... Molecular and cellular biology 16 (11), 6083-6095, 1996	763	1996
Toward clinical application of the Keap1–Nrf2 pathway T Suzuki, H Motohashi, M Yamamoto Trends in pharmacological sciences 34 (6), 340-346, 2013	762	2013
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity T Yamamoto, T Suzuki, A Kobayashi, J Wakabayashi, J Maher, ... Molecular and cellular biology 28 (8), 2758-2770, 2008	579	2008
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors H Motohashi, T O'Connor, F Katsuoka, JD Engel, M Yamamoto Gene 294 (1-2), 1-12, 2002	568	2002
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics T Akaike, T Ida, FY Wei, M Nishida, Y Kumagai, MM Alam, H Ihara, ... Nature communications 8 (1), 1177, 2017	515	2017
Keap1 degradation by autophagy for the maintenance of redox homeostasis K Taguchi, N Fujikawa, M Komatsu, T Ishii, M Unno, T Akaike, ... Proceedings of the National Academy of Sciences 109 (34), 13561-13566, 2012	506	2012
The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism Y Mitsuishi, H Motohashi, M Yamamoto Frontiers in oncology 2, 200, 2012	475	2012
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, ... Biochemical and biophysical research communications 339 (1), 79-88, 2006	475	2006
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway H Motohashi, F Katsuoka, JD Engel, M Yamamoto Proceedings of the National Academy of Sciences 101 (17), 6379-6384, 2004	422	2004

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