| Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives A Ramachandran, RGJ Visschers, L Duan, JY Akakpo, H Jaeschke Journal of clinical and translational research 4 (1), 75, 2018 | 189 | 2018 |
| Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure H Jaeschke, JY Akakpo, DS Umbaugh, A Ramachandran Toxicological Sciences 174 (2), 159-167, 2020 | 165 | 2020 |
| The role of apoptosis in acetaminophen hepatotoxicity H Jaeschke, L Duan, JY Akakpo, A Farhood, A Ramachandran Food and chemical toxicology 118, 709-718, 2018 | 141 | 2018 |
| 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes JY Akakpo, A Ramachandran, SE Kandel, HM Ni, SC Kumer, BH Rumack, ... Human & Experimental Toxicology 37 (12), 1310-1322, 2018 | 106 | 2018 |
| Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls H Jaeschke, OB Adelusi, JY Akakpo, NT Nguyen, G Sanchez-Guerrero, ... Acta Pharmaceutica Sinica B 11 (12), 3740-3755, 2021 | 96 | 2021 |
| Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-Jun N-terminal kinase JY Akakpo, A Ramachandran, L Duan, MA Schaich, MW Jaeschke, ... Toxicological Sciences 170 (1), 57-68, 2019 | 94 | 2019 |
| Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose JY Akakpo, A Ramachandran, SC Curry, BH Rumack, H Jaeschke Archives of toxicology 96 (2), 453-465, 2022 | 76 | 2022 |
| The effect of 4-methylpyrazole on oxidative metabolism of acetaminophen in human volunteers AM Kang, A Padilla-Jones, ES Fisher, JY Akakpo, H Jaeschke, ... Journal of Medical Toxicology 16, 169-176, 2020 | 71 | 2020 |
| Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity A Ghallab, R Hassan, U Hofmann, A Friebel, Z Hobloss, L Brackhagen, ... Journal of Hepatology 77 (1), 71-83, 2022 | 59 | 2022 |
| 4-methylpyrazole protects against acetaminophen-induced acute kidney injury JY Akakpo, A Ramachandran, H Orhan, SC Curry, BH Rumack, ... Toxicology and applied pharmacology 409, 115317, 2020 | 55 | 2020 |
| Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice NT Nguyen, K Du, JY Akakpo, DS Umbaugh, H Jaeschke, ... Toxicology letters 338, 21-31, 2021 | 53 | 2021 |
| Pleiotropic role of p53 in injury and liver regeneration after acetaminophen overdose P Borude, B Bhushan, S Gunewardena, J Akakpo, H Jaeschke, U Apte The American journal of pathology 188 (6), 1406-1418, 2018 | 47 | 2018 |
| Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans L Duan, A Ramachandran, JY Akakpo, JL Weemhoff, SC Curry, ... Toxicology letters 301, 125-132, 2019 | 35 | 2019 |
| Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease J Willebrords, M Maes, IVA Pereira, TC da Silva, VM Govoni, VV Lopes, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (3), 819-830, 2018 | 33 | 2018 |
| Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole JY Akakpo, MW Jaeschke, A Ramachandran, SC Curry, BH Rumack, ... Archives of toxicology 95, 3377-3391, 2021 | 31 | 2021 |
| Novel strategies for the treatment of acetaminophen hepatotoxicity JY Akakpo, A Ramachandran, H Jaeschke Expert opinion on drug metabolism & toxicology 16 (11), 1039-1050, 2020 | 27 | 2020 |
| Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice H Qian, Q Bai, X Yang, JY Akakpo, L Ji, L Yang, T Rülicke, K Zatloukal, ... Acta Pharmaceutica Sinica B 11 (12), 3791-3805, 2021 | 20 | 2021 |
| Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity L Duan, A Ramachandran, JY Akakpo, BL Woolbright, Y Zhang, ... Toxicology and applied pharmacology 387, 114849, 2020 | 18 | 2020 |
| Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice NT Nguyen, JY Akakpo, JL Weemhoff, A Ramachandran, WX Ding, ... Archives of toxicology 95, 1463-1473, 2021 | 17 | 2021 |
| Desorption electrospray ionization mass spectrometry imaging allows spatial localization of changes in acetaminophen metabolism in the liver after intervention with 4 … JY Akakpo, MW Jaeschke, Y Etemadi, A Artigues, S Toerber, H Olivos, ... Journal of the American Society for Mass Spectrometry 33 (11), 2094-2107, 2022 | 16 | 2022 |
